Gavage‐administered lactoferrin promotes palatal expansion stability in a dose‐dependent manner

Xiao, Xiaoyue; Yang, Cheng; Huang, Li; Liu, Ruojing; Zou, Shujuan; Chen, Jianwei

doi:10.1111/odi.13989

Cited by 5 publications

(3 citation statements)

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“…However, the same investigation did not demonstrate the inhibition of osteoclastic bone resorption by LF, furthermore, the osteoclastogenesis process was not affected (31) . The study of Xiao et al (32) also demonstrated that LF enhanced the migration and proliferation of osteoblasts cells, which could stimulate bone formation in the mid-palatal suture expansion. The levels of bone formation markers such as osteocalcin, and Collagen type I were distinctly elevated after treatment with LF (100 mg/ kg and 1 g/kg) dose-dependently (32) .…”

Section: Discussionmentioning

confidence: 91%

“…The study of Xiao et al (32) also demonstrated that LF enhanced the migration and proliferation of osteoblasts cells, which could stimulate bone formation in the mid-palatal suture expansion. The levels of bone formation markers such as osteocalcin, and Collagen type I were distinctly elevated after treatment with LF (100 mg/ kg and 1 g/kg) dose-dependently (32) . Additionally, Li et.…”

Section: Discussionmentioning

confidence: 91%

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The protective effect of Lactoferrin on the alveolar bone loss induced by Carbamazepine in rats

Abdel Fattah,

Hamza

2024

Egyptian Dental Journal

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Introduction: Carbamazepine is one of the widely used anti-epileptic medications associated with elevated fracture rates. Lactoferrin is a secretory glycoprotein with iron binding capacity and one of the transferrin family of proteins. It is naturally found in colostrum and milk in the highest concentrations. It is found to have protective anti-inflammatory, antioxidant, and antimicrobial actions.Aim: This study was designed to evaluate the protective influence of lactoferrin on the alveolar bone damage mediated by carbamazepine in rats. Materials and Methods:Twenty-four healthy female Wistar albino rats were randomly distributed into 3 groups, 8 rats each. Group I-control, rats were given a daily dose of saline. Group II-carbamazepine, rats received carbamazepine 75mg/kg/day orally for 5 weeks. Group IIIcarbamazepine and lactoferrin, rats received carbamazepine 75mg/kg/day in addition to lactoferrin 100 mg/kg/day orally for 5 weeks. After euthanasia, the mandibles of all rats were collected and prepared to be evaluated by light and scanning electron microscopy, histomorphometry, and energydispersive x-ray microanalysis. Results:The alveolar bone in the carbamazepine group showed marked porosity and trabecular thinning in comparison to the control and lactoferrin groups demonstrated by both light and scanning electron microscopy. The bone volume ratio values were significantly higher in carbamazepine-lactoferrin and control groups than in the carbamazepine group. The percentage of calcium mineralization detected by Energy Dispersive X-ray spectroscopy in lactoferrin group was comparable to the control and significantly higher than carbamazepine group.Conclusions: Lactoferrin supplementation could successfully reduce the porosity provoked by anti-epileptic medications in the alveolar bone.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 91%

The protective effect of Lactoferrin on the alveolar bone loss induced by Carbamazepine in rats

Abdel Fattah,

Hamza

2024

Egyptian Dental Journal

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“…A customized expansion device was fabricated as described previously 9 , 10 by bending a 0.014-inch Australian wire into a two-eye open spring. When the expander was inactivated, both arms were parallel ( Figure 1A ).…”

Section: Methodsmentioning

confidence: 99%

Suppressing STAT3 activation impairs bone formation during maxillary expansion and relapse

et al. 2023

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Objectives The mid-palatal expansion technique is commonly used to correct maxillary constriction in dental clinics. However, there is a tendency for it to relapse, and the key molecules responsible for modulating bone formation remain elusive. Thus, this study aimed to investigate whether signal transducer and activator of transcription 3 (STAT3) activation contributes to osteoblast-mediated bone formation during palatal expansion and relapse. Methodology In total, 30 male Wistar rats were randomly allocated into Ctrl (control), E (expansion only), and E+Stattic (expansion plus STAT3-inhibitor, Stattic) groups. Micro-computed tomography, micromorphology staining, and immunohistochemistry of the mid-palatal suture were performed on days 7 and 14. In vitro cyclic tensile stress (10% magnitude, 0.5 Hz frequency, and 24 h duration) was applied to rat primary osteoblasts and Stattic was administered for STAT3 inhibition. The role of STAT3 in mechanical loading-induced osteoblasts was confirmed by alkaline phosphatase (ALP), alizarin red staining, and western blots. Results The E group showed greater arch width than the E+Stattic group after expansion. The differences between the two groups remained significant after relapse. We found active bone formation in the E group with increased expression of ALP, COL-I, and Runx2, although the expression of osteogenesis-related factors was downregulated in the E+stattic group. After STAT3 inhibition, expansive force-induced bone resorption was attenuated, as TRAP staining demonstrated. Furthermore, the administration of Stattic in vitro partially suppressed tensile stress-enhanced osteogenic markers in osteoblasts. Conclusions STAT3 inactivation reduced osteoblast-mediated bone formation during palatal expansion and post-expansion relapse, thus it may be a potential therapeutic target to treat force-induced bone formation.

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Medication-related osteonecrosis of the jaw: evolving research for multimodality medical management

Abdolrahmani,

Epstein,

Samim

2024

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Gavage‐administered lactoferrin promotes palatal expansion stability in a dose‐dependent manner

Cited by 5 publications

References 28 publications

The protective effect of Lactoferrin on the alveolar bone loss induced by Carbamazepine in rats

The protective effect of Lactoferrin on the alveolar bone loss induced by Carbamazepine in rats

Suppressing STAT3 activation impairs bone formation during maxillary expansion and relapse

Medication-related osteonecrosis of the jaw: evolving research for multimodality medical management

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