“…FGFRs represent tyrosine kinase receptors, with FGFR2 being involved in the upregulation of RAS, JAK, and PI3K/mTOR pathways; thus, FGFR2 aberrations play a role in modifying processes of cellular migration, angiogenesis, proliferation, and survival [ 43 , 44 ]. In the last decade, a wide number of agents targeting FGFR isoforms have been investigated in iCCA patients, such as infigratinib, pemigatinib, derazantinib, erdafitinib and, more recently, futibatinib ( Table 1 ) [ 45 , 46 ].…”