Gated SPECT in patients with hypertrophic obstructive cardiomyopathy undergoing transcoronary ethanol septal ablation

Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiomyopathy and the most common cause of cardiac death in young athletes in the U.S. Noninvasive imaging plays an important role in detecting the disease, understanding its pathophysiology, and selecting as well as guiding appropriate therapy. In this review, we discuss the existing methodology with emphasis on current and emerging clinical applications in patients with HCM.

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“…In addition, significant reductions in lung to heart and in septal to lateral wall count ratios were noted (48). These observations Figure 8.…”

Section: Spect Monitoring Of Results Of Non-medical Therapymentioning

confidence: 88%

“…Treadmill, bicycle exercise, atrial pacing, dipyridamole, and adenosine were examined in this population. Defects, both reversible and fixed, were noted from 10% to 100% of the patients imaged (see Table 3 from Keng et al [48] for a summary). Most defects involve the septum but can occur in other walls.…”

Section: Nuclear Imagingmentioning

confidence: 97%

Noninvasive Cardiac Imaging in Patients With Hypertrophic Cardiomyopathy

Nagueh

Mahmarian

2006

Journal of the American College of Cardiology

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“…The prevalence of both reversible and fixed perfusion abnormalities is quite common and has been reported to be between 20 and 75% [43][44][45][46][47]. Data from one of the largest series consisting of 102 patients with HCM (mean age 54 AE 16 years, 56% men, 55% obstructive) reported 54% prevalence of perfusion abnormalities [46].…”

Section: Nuclear Cardiac Imaging In the Assessment Of Myocardial Ischmentioning

confidence: 94%

“…One of them is monitoring of results of nonmedical therapy such as surgical myectomy or ethanol septal reduction procedures, which can result in improvement of the perfusion defect or, inversely, new fixed perfusion due to myocardial injury and scarring [43,44] ( Fig. 6).…”

Section: Nonischemia Evaluation: Roles Of Nuclear Cardiac Imaging In mentioning

confidence: 99%

Diagnosis of ischemia in hypertrophic cardiomyopathy

Chaikriangkrai

Chebrolu

Bhatti

et al. 2015

Current Opinion in Cardiology

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“…58 Finally, high prevalence of late gadolinium enhancement, primarily in a patchy, multifocal mid-wall distribution in areas of hypertrophy, has been found by cardiac magnetic resonance imaging 59,60 and has been correlated with the presence of non-sustained ventricular tachycardia 60-63 and cardiac mortality. 64 Despite such convincing evidence in the literature, assessment of myocardial ischemia has not been considered part of the evaluation and clinical management of patients with HCM.…”

Section: Role Of Myocardial Ischemia In Sudden Cardiac Deathmentioning

confidence: 99%