“…8 In UUTUC, however, UGT1A expression inversely correlated only with pT stage, but not tumor grade. 16 In contrast, in our recent studies, RPTs showed lower positive rates of other transcription factors, such as androgen receptor known to promote urothelial tumor outgrowth 7,25 (11.1% vs 28.0%, P = 0.070), 17 estrogen receptorb that could inhibit urothelial tumor outgrowth 8,25 (51.1% vs 72.0%, P = 0.056), 17 GATA3 shown to function as a tumor suppressor 26,27 (35.6% vs 66.0%, P = 0.004) 28 and Wound-healing assay in UMUC3-control-siRNA versus UMUC3-UGT1A-siRNA. Loss or weak expression of UGT1A was also associated with the presence of other known prognostic factors, such as lymphovascular invasion and concomitant CIS, but not lymph node metastasis or hydronephrosis.…”