GATA3 expression in pulmonary mucinous adenocarcinoma presenting as a distant metastasis: A case report

Shaker, Nada; Hanline, Cecelia; Tynski, Isabella M.; Tynski, Zofia; Amadi, Chiemezie C.; Parwani, Anil V.; Shilo, Konstantin

doi:10.1016/j.hpr.2022.300642

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Gata3 In Diagnostic Histopathology Practice -Uses and Pitfalls1

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2023

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“…• A recently described pitfall is the expression of GATA3 in pulmonary mucinous adenocarcinoma [49]. This case report also described lack of TTF1 and Napsin expression.…”

Section: Gata3 In Diagnostic Histopathology Practice -Uses and Pitfallsmentioning

confidence: 52%

Gene of the month: GATA3

Qiang,

Jubber,

Lloyd

et al. 2023

J Clin Pathol

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GATA binding protein 3 (GATA3) is a zinc-finger pioneer transcription factor involved in diverse processes. GATA3 regulates gene expression through binding nucleosomal DNA and facilitating chromatin remodelling. Post-translational modifications modulate its activity. During development, GATA3 plays a key role in cell differentiation. Mutations inGATA3are linked to breast and bladder cancer. GATA3 expression is a feature of the luminal subtype of bladder cancer and has implications for immune status and therapeutic response. It also has clinical relevance in squamous cell carcinomas and soft tissue sarcomas. This paper reviews the structure and function of GATA3, its role in cancer and its use and pitfalls as an immunohistochemical marker.

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“…• A recently described pitfall is the expression of GATA3 in pulmonary mucinous adenocarcinoma [49]. This case report also described lack of TTF1 and Napsin expression.…”

Section: Gata3 In Diagnostic Histopathology Practice -Uses and Pitfallsmentioning

confidence: 52%