GATA3 expression and its relationship with clinicopathological parameters in invasive breast carcinomas

Çakır, Aslı; Gönül, İpek Işık; Ekinci, Özgür; Çetin, Bülent; Benekli, Mustafa; Uluoğlu, Ömer

doi:10.1016/j.prp.2016.12.010

Cited by 22 publications

(24 citation statements)

References 55 publications

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“…Previous works have highlighted the prognostic and predictive value of expression of GATA3 in breast carcinoma and shown using immunohistochemistry that it is closely correlated with ERα expression. [6][7][8]10,20] In the present study too, the expression of GATA3 was directly associated with ER, PR and the luminal subtype. But some researches suggest the relationship between GATA3 and the ER stimulated pathways is not direct and may be bridged by the forkhead family transcription factor, FOXA1.…”

Section: Discussionsupporting

confidence: 63%

“…They found that GATA3 and estrogen receptor (ER) are involved in a cross-regulatory loop and are therefore frequently co-expressed in breast cancers. [6][7][8][9][10][11][12][13][14]20] But expression of GATA3 in triple-negative (ER, PR, and HER2 negative) breast carcinomas is most relevant because this molecular subtype exhibits a negative immunohistochemical profile for most markers of breast origin. Due to low sensitivities of mammaglobin and GCDFP15, GATA3 may potentially be a useful marker in triple negative breast cancer.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, the results obtained from these studies have not been uniform and the clinical use of immunohistochemistry of GATA3 remains questionable. Some studies demonstrate it to be an independent prognostic marker [7][8][9][10] while others show it lacks prognostic benefit. [12,18,14] Determination of prognosis and identification of suitable treatment modalities remain the most immediate challenges after diagnosis of carcinoma breast.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Immunohistochemical Analysis of Expression of GATA3 in Carcinoma Breast and its Correlation with Prognostic Parameters

Suri¹,

Ahluwalia²

2021

Ann of Pathol and Lab Med

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Background: GATA3 plays an essential role in the normal development and function of the mammary gland where it promotes the luminal transcriptional program. Its loss is implicated in the pathogenesis of breast cancer. We proposed to study the expression of GATA3 in carcinoma breast by immunohistochemistry and determine its correlation with prognostic parameters. Methods: The expression pattern of GATA3 was evaluated by immunohistochemistry in 30 cases of invasive breast carcinoma. GATA3 scoring was done and a score of ≥ 1+ was considered positive. Patient characteristics, including age, tumour laterality, tumour size, lymph node status, tumour grade, histological type, molecular subtypes were collected. The relationships between protein expression and clinicopathological variables were analysed. Statistical significance was determined by Pearson’s chi-square test and Mann Whitney U test (for age). Result: 46.7% of cases (14/30) scored positive for GATA3 expression in tumour cells including 63% of luminal subtypes, 14% of Her-2 neu enriched carcinomas and 20% of triple negative carcinomas. Most positive cases (35.7%) demonstrated 3+ staining. GATA3 expression showed an inverse association with histological grade (P = 0.012) and HER-2 overexpression (P = 0.038), and a direct association with ER expression (P =0.017) and PR expression (P =0.009). Conclusion: GATA3 is luminal marker as it shows strong association with ER and PR in breast cancers. High GATA3 expression is also correlated good prognostic parameters like low tumour grade. Our findings advocate for GATA3 as a promising new breast-specific immunomarker.

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Section: Discussionsupporting

confidence: 63%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Immunohistochemical Analysis of Expression of GATA3 in Carcinoma Breast and its Correlation with Prognostic Parameters

Suri¹,

Ahluwalia²

2021

Ann of Pathol and Lab Med

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“…Of all the GATA family factors, GATA-3 is considered an emerging and specific biomarker of breast cancer that shows less invasive, has fewer metastases, and therefore associates with a better prognosis. ERα-positive, luminal subtype, or well-differentiated epithelial breast cancer expresses a notably high level of GATA-3 compared to ER-negative invasive breast cancer 31 , 32 . GATA-3, known to be abundantly expressed in luminal cells, plays a crucial role during epithelial proliferation and is required for development and formation of normal mammary gland 6 , 7 .…”

Section: Discussionmentioning

confidence: 99%

Notch3 inhibits epithelial–mesenchymal transition in breast cancer via a novel mechanism, upregulation of GATA-3 expression

et al. 2018

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Notch3 and GATA binding protein 3 (GATA-3) have been, individually, shown to maintain luminal phenotype and inhibit epithelial–mesenchymal transition (EMT) in breast cancers. In the present study, we report that Notch3 expression positively correlates with that of GATA-3, and both are associated with estrogen receptor-α (ERα) expression in breast cancer cells. We demonstrate in vitro and in vivo that Notch3 suppressed EMT and breast cancer metastasis by activating GATA-3 transcription. Furthermore, Notch3 knockdown downregulated GATA-3 and promoted EMT; while overexpression of Notch3 intracellular domain upregulated GATA-3 and inhibited EMT, leading to a suppression of metastasis in vivo. Moreover, inhibition or overexpression of GATA-3 partially reversed EMT or mesenchymal–epithelial transition induced by Notch3 alterations. In breast cancer patients, high GATA-3 expression is associated with higher Notch3 expression and lower lymph node metastasis, especially for hormone receptor (HR) positive cancers. Herein, we demonstrate a novel mechanism whereby Notch3 inhibit EMT by transcriptionally upregulating GATA-3 expression, at least in part, leading to the suppression of cancer metastasis in breast cancers. Our findings expand our current knowledge on Notch3 and GATA-3's roles in breast cancer metastasis.

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“…More recent studies have revealed that GATA1 and GATA2 also participate in the progression of breast cancer and prostate cancer via EMT processes 4,5 . GATA3 plays an integral role in luminal cell differentiation in mammary glands 6 . Consequently, GATA3 has recently been drawing scientists’ attention in breast cancer, but the supporting evidence is inconclusive 7 .…”

Section: Introductionmentioning

confidence: 99%

Comprehensive analysis of the GATA transcription factor gene family in breast carcinoma using gene microarrays, online databases and integrated bioinformatics

Jiang²,

et al. 2019

Sci Rep

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Integrated studies of accumulated data can be performed to obtain more reliable information and more feasible measures for investigating the potential diagnostic and prognostic biomarkers of breast cancer and exploring related molecular mechanisms. Our study aimed to explore the GATA family members involved in breast cancer by integrating data from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO) and other online databases. We performed an integrated analysis of published studies from GEO and analyzed clinical data from TCGA and GTEx to evaluate the clinical significance and prognosis values of the GATA family in breast cancer. GATA3 was found to be upregulated and exhibited a favorable value in the diagnosis and prognosis of breast cancer. Through this study, we identified possible GATA3-correlated genes and core pathways that play an important role, which requires further investigation in breast cancer.

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GATA3 expression and its relationship with clinicopathological parameters in invasive breast carcinomas

Cited by 22 publications

References 55 publications

Immunohistochemical Analysis of Expression of GATA3 in Carcinoma Breast and its Correlation with Prognostic Parameters

Immunohistochemical Analysis of Expression of GATA3 in Carcinoma Breast and its Correlation with Prognostic Parameters

Notch3 inhibits epithelial–mesenchymal transition in breast cancer via a novel mechanism, upregulation of GATA-3 expression

Comprehensive analysis of the GATA transcription factor gene family in breast carcinoma using gene microarrays, online databases and integrated bioinformatics

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