GATA-factor dependence of the multitype zinc-finger protein FOG-1 for its essential role in megakaryopoiesis

Chang, Aaron N.; Cantor, Alan B.; Fujiwara, Yuko; Lodish, Maya; Droho, Steven; Crispino, John D.; Orkin, Stuart H.

doi:10.1073/pnas.142302099

Cited by 159 publications

(153 citation statements)

References 35 publications

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“…Cooperation between GATA-1 and FOG-1 is required for normal erythropoiesis (Crispino et al, 1999), and within the megakaryocyte lineage FOG-1 acts with either GATA-1 or GATA-2 to direct differentiation of early precursors (Nichols et al, 2000;Chang et al, 2002;Cantor et al, 2002;Garriga-Canut and Orkin, 2004). FOG-1 is co-expressed with GATA-3 in naive T-cells and may repress T helper 2 cell development (Zhou et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

GATA‐4:FOG interactions regulate gastric epithelial development in the mouse

Jacobsen¹,

Mannisto²,

Porter-Tinge³

et al. 2005

Developmental Dynamics

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Transcription factor GATA-4 is a key participant in cytodifferentiation of the mouse hindstomach. Here we show that GATA-4 cooperates with a Friend-of-GATA (FOG) cofactor to direct gene expression in this segment of gut. Immunohistochemical staining revealed that GATA-4 and FOG-1 are co-expressed in hindstomach epithelial cells from embryonic days (E) 11.5 to 18.5. The other member of the mammalian FOG family, FOG-2, was not detected in gastric epithelium. To show that GATA-4:FOG interactions influence stomach development, we analyzed Gata4 ki/ki mice, which express a mutant GATA-4 that cannot bind FOG cofactors. Sonic Hedgehog, an endoderm-derived signaling molecule normally down-regulated in the distal stomach, was over-expressed in hindstomach epithelium of E11.5 Gata4 ki/ki mice, and there was a concomitant decrease in fibroblast growth factor-10 in adjacent mesenchyme. We conclude that functional interaction between GATA-4 and a member of the FOG family, presumably FOG-1, is required for proper epithelial-mesenchymal signaling in the developing stomach. Developmental Dynamics 234:355-362, 2005.

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Section: Discussionmentioning

confidence: 99%

GATA‐4:FOG interactions regulate gastric epithelial development in the mouse

Jacobsen¹,

Mannisto²,

Porter-Tinge³

et al. 2005

Developmental Dynamics

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“…In addition, this complex is required for erythrocyte and megakaryocyte differentiation (2)(3)(4). FOG-1 may also act with GATA-2 to initiate megakaryopoiesis (5). In general, FOG proteins bind the N-terminal zinc-finger of their respective GATA partners.…”

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confidence: 99%

Combinatorial interactions of Serpent, Lozenge, and U-shaped regulate crystal cell lineage commitment during Drosophila hematopoiesis

Fossett

Hyman

Gajewski

et al. 2003

Proc. Natl. Acad. Sci. U.S.A.

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The GATA factor Serpent (Srp) is required for hemocyte precursor formation during Drosophila hematopoiesis. These blood cell progenitors give rise to two distinct lineages within the developing embryo. Lozenge, a Runx protein homologue, and Glial cells missing-1 and -2 are essential for crystal cell and plasmatocyte production, respectively. In contrast U-shaped, a Friend of GATA class factor, antagonizes crystal cell formation. Here we show that Srp, Lozenge, and U-shaped interact in different combinations to regulate crystal cell lineage commitment. Coexpression of Srp and Lozenge synergistically activated the crystal cell program in both embryonic and larval stages. Furthermore, expression of Lozenge and SrpNC, a Srp isoform with N-and C-terminal zinc fingers, inhibited u-shaped expression, indicating that crystal cell activation coincided with the down-regulation of this repressor-encoding gene. In contrast, whereas U-shaped and SrpNC together blocked crystal cell production, coexpression of U-shaped with noninteracting Srp proteins failed to prevent overproduction of this hemocyte population. Such results indicated that U-shaped and SrpNC must interact to block crystal cell production. Taken together, these studies show that the specialized SrpNC isoform plays a pivotal role during crystal cell lineage commitment, acting as an activator or repressor depending on the availability of specific transcriptional coregulators. These findings provide definitive proof of the combinatorial regulation of hematopoiesis in Drosophila and an in vivo demonstration of GATA and Runx functional interaction in a blood cell commitment program.

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“…Differences in megakaryocyte differentiation between GATA-1-and FOG-1-deficient mice can be accounted for by overlapping functions of GATA-1 and GATA-2 as GATA-1/ GATA-2 double knock-in mice ablated for their interaction with FOG-1 phenocopy mice lacking FOG-1. Thus, at early stages, either GATA-1 or GATA-2 functions with FOG-1, whereas at later times megakaryocytic differentiation is dependent on GATA-1 and FOG-1 (13). Patients with a rare syndrome of congenital dyserythropoietic anemia and thrombocytopenia who exhibit hyperproliferation of abnormal megakaryocytes resembling GATA-1 Ϫ megakaryocytes harbor a point mutation in the GATA-1 gene that reduces its affinity for FOG-1 (14).…”

mentioning

confidence: 99%

Transforming Acidic Coiled-coil Protein 3 (TACC3) Controls Friend of GATA-1 (FOG-1) Subcellular Localization and Regulates the Association between GATA-1 and FOG-1 during Hematopoiesis

Garriga-Canut

Orkin

2004

Journal of Biological Chemistry

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Physical association between the transcription factor GATA-1 and the cofactor, Friend of GATA-1 (FOG-1), is essential for the differentiation of two blood cell types, erythroid cells and megakaryocytes. However, little is known regarding the mechanisms that modulate their interaction within cells. In the present study, we have identified TACC3 as a FOG-1-interacting protein. Transforming acidic coiled-coil protein 3 (TACC3), a protein that is highly expressed in hematopoietic cells, has been reported to have a critical role in the expansion of immature hematopoietic progenitors. We show that TACC3 affects FOG-1 nuclear localization, altering the interaction between GATA-1 and FOG-1. However, GATA-1 competes with TACC3 in the interaction with FOG-1. We observe that high levels of TACC3 inhibit the function of FOG-1 as a transcriptional cofactor of GATA-1. Furthermore, forced expression of TACC3 to levels similar to those found in progenitor cells delays terminal maturation of MEL and G1ER cells, two cell models of erythroid cell development. We suggest a role for TACC3 in regulating the cellular distribution of FOG-1 and thus the direct interaction of GATA-1 and FOG-1 as a mechanism to control the transition between expansion of multipotential progenitor cell populations and final stages of erythroid maturation.

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GATA-factor dependence of the multitype zinc-finger protein FOG-1 for its essential role in megakaryopoiesis

Cited by 159 publications

References 35 publications

GATA‐4:FOG interactions regulate gastric epithelial development in the mouse

GATA‐4:FOG interactions regulate gastric epithelial development in the mouse

Combinatorial interactions of Serpent, Lozenge, and U-shaped regulate crystal cell lineage commitment during Drosophila hematopoiesis

Transforming Acidic Coiled-coil Protein 3 (TACC3) Controls Friend of GATA-1 (FOG-1) Subcellular Localization and Regulates the Association between GATA-1 and FOG-1 during Hematopoiesis

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