Gastroschisis and Omphalocele

Ledbetter, Daniel J.

doi:10.1016/j.suc.2005.12.003

Cited by 136 publications

(147 citation statements)

References 27 publications

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“…Several clinical papers [5][6][7][8] show that the prevalence of GS has increased signifi cantly in recent years throughout the world, i.e. by 67% in two years.…”

Section: Discussionmentioning

confidence: 99%

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Characteristics of the clinical development of a newborn with gastroschisis in an intensive care unit in latin america

Redondo¹,

Feferbaum

Vieira

et al. 2016

J. Hum. Growth Dev.

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Introduction: Congenital malformations are major diseases observed at birth. They are the second most common cause of death in the neonatal population, the fi rst one being prematurity.Objective: To characterise the clinical outcome of newborns with gastroschisis (GS) in a neonatal intensive care unit. Methods:A retrospective observational clinical study in 50 infants with GS using the association of intestinal abnormalities, impossibility of primary closure of the abdominal defect and reoperation necessity as classifi cation criteria for the disease. The signifi cance level was p < 0.05. Results:The hospitalisation to primary surgery occurred with a median age of 2 hours. Fourteen percent of children were subjected to a primary silo interposition and 24% had associated intestinal malformation. Nineteen newborns (NB) required more than one surgery. The median length of stay was 33 days, higher in patients with complex GS (56 days). All NB recovered from urine output 48 hours after surgery and 40% had hyponatraemia and oligoanuria in this period. There was no difference between the natraemia and fasting time (p = 0.79). Weight gain was similar in both groups with total parenteral nutrition and became signifi cantly higher in patients with simple GS after enteral feeding (p = 0.0046). These NB evolved 2.4 times less cholestasis. Late-onset sepsis occurred in 58% of patients and was related to the infection of the central venous catheter in 37.9% of cases. Mortality was higher in infants infected with complex GS and the overall mortality rate was 14%. Conclusion:Clinical characterisation of newborns with gastroschisis depends on the complexity and the knowledge and conduct of morbidities to reduce mortality.Key words: gastroschisis, new-born, mortality, total parenteral nutrition, renal insuffi ciency, infection. INTRODUCTIONCongenital malformations are major diseases observed at birth. In the United States, a prevalence of about 3% 1 is cited. In Brazil, a study at the Fernandez Figueira Institute in Rio de Janeiro found that the prevalence was similar, i.e. 2.7% among live newborns (NB) and 6.7% among stillbirths. Among the causes of death, neonatal malformations are the second most common reason, the fi rst one being prematurity 2 .Gastroschisis (GS) is a congenital malformation of the abdominal wall that has increased in prevalence worldwide; its causes have not been fully elucidated 3 . In the 1960s, the prevalence of this disease was 1:50,000 live births. However, Kirby et al. 4 - -Characteristics of the clinical development of a newborn with gastroschisis in an intensive care unit in latin america J Hum Growth Dev. 2016; 26(2): 190-198 DOI: http://dx.doi.org/10.7322/jhgd.119266 temporal increase of 2.23 per 10,000 live births to 4.42 per 10,000 Regarding the defi nition of live births. The current prevalence in South America is 2.9:10,000 5 . This disease is characterised by a defect in abdominal wall closure with herniation of the intestines and other abdominal organs into the amniotic cavity. ...

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“…Several clinical papers [5][6][7][8] show that the prevalence of GS has increased signifi cantly in recent years throughout the world, i.e. by 67% in two years.…”

Section: Discussionmentioning

confidence: 99%

“…However, Kirby et al 4 recently reported that in the period from 1995 to 2005 in the United States, there was a DOI: http://dx.doi.org/10.7322/jhgd.119266 temporal increase of 2.23 per 10,000 live births to 4.42 per 10,000 Regarding the defi nition of live births. The current prevalence in South America is 2.9:10,000 5 .…”

Section: Introductionmentioning

confidence: 99%

Characteristics of the clinical development of a newborn with gastroschisis in an intensive care unit in latin america

Redondo¹,

Feferbaum

Vieira

et al. 2016

J. Hum. Growth Dev.

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“…The proximal portion of the lesion communicates with the peritoneal cavity (asterisk); the distal portion extends into the labia majora (arrow) cord with herniation of the bowels and sometimes the genitourinary tract; there is no sac overlying the eviscerated bowel loops. Omphalocele is caused by failure of the bowels to return into the abdomen after normal herniation into the umbilical cord during the 6th to 10th week of embryological development [8]. Gastroschisis may be secondary to vascular insufficiency due to premature involution of the right umbilical vein or the right omphalomesenteric artery [9].…”

Section: Discussionmentioning

confidence: 99%

Palpable inguinal mass in a girl after omphalocele repair: US findings

Esposito¹,

Fronzo

Migliaccio

et al. 2013

J Ultrasound

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Hydrocele of the canal of Nuck is a rare cause of inguinal swelling in females. We present the case of a 9-year-old girl, who underwent omphalocele repair shortly after birth. She presented with a painless swelling in the right inguinal region; it was of a hard elastic consistency and ultrasound image showed an oval lesion containing fluid, located in the subcutaneous soft tissue. Removal of the lesion and histological examination of the surgical specimen confirmed cyst of the canal of Nuck.Keywords Ultrasound Á Hydrocele Á Canal of Nuck Riassunto L'idrocele del canale di Nuck è una rara causa di tumefazione inguinale nelle donne. Presentiamo il caso di una bambina di 9 anni, operata alla nascita per onfalocele, con una tumefazione nella regione inguinale destra non dolente, di consistenza duro-elastica, che all'ecografia appariva come una formazione ovalare a contenuto fluido localizzata nel contesto dei tessuti molli sottocutanei. L'asportazione della lesione e l'esame istologico hanno confermato la diagnosi di cisti del canale di Nuck.

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“…This is also known as exomphalos. Incidence of omphalocele ranges between 1.5 and 3 per 10,000 births 1 . Children with omphalocele have very high (50%-70%) incidence of associated anomalies 1 .…”

Section: Introductionmentioning

confidence: 99%