Gastroretentive raft liquid delivery system as a new approach to release extension for carrier-mediated drug

Abouelatta, Samar M.; Aboelwafa, Ahmed A.; El‐Gazayerly, Omaima N.

doi:10.1080/10717544.2018.1474969

Cited by 40 publications

(25 citation statements)

References 28 publications

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“…In vivo assessment was performed in rats to evaluate gastric residence of the gel formed. The increment in relative bioavailability of GBP from the optimized formula was 1.7 fold compared to commercially available Neurontin ® [158].…”

Section: Raft-forming Systemsmentioning

confidence: 94%

In-Depth Study into Polymeric Materials in Low-Density Gastroretentive Formulations

et al. 2020

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The extensive use of oral dosage forms for the treatment of diseases may be linked to deficient pharmacokinetic properties. In some cases the drug is barely soluble; in others, the rapid transit of the formulation through the gastrointestinal tract (GIT) makes it difficult to achieve therapeutic levels in the organism; moreover, some drugs must act locally due to a gastric pathology, but the time they remain in the stomach is short. The use of formulations capable of improving all these parameters, as well as increasing the resident time in the stomach, has been the target of numerous research works, with low-density systems being the most promising and widely explored, however, there is further scope to improve these systems. There are a vast variety of polymeric materials used in low-density gastroretentive systems and a number of methods to improve the bioavailability of the drugs. This works aims to expedite the development of breakthrough approaches by providing an in-depth understanding of the polymeric materials currently used, both natural and synthetic, their properties, advantages, and drawbacks.

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Section: Raft-forming Systemsmentioning

confidence: 94%

In-Depth Study into Polymeric Materials in Low-Density Gastroretentive Formulations

et al. 2020

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“…Thus, they can be used for the effective management of gastric esophageal reflux disease. When raft-forming systems come into contact with gastric fluid, they swell and form a viscous cohesive gel leading to the formation of a continuous layer termed as rafts [17,62]. Fabregas et al [89] explained the antacid raft-forming floating system.…”

Section: Current Pharmaceutical Technologies Of Grddsmentioning

confidence: 99%

“…Thus, CO 2 gas is generated that lowers the bulk density of the system, and as a result, the raft floats on the gastric fluid. Nabarawi et al [62] developed a controlled release floating raft system of mebeverine hydrochloride, and evaluated different excipients for their floating behavior and in vitro controlled-release. It forms a viscous and cohesive gel when it swells and entraps CO 2 bubbles produced by the reaction of carbonates and gastric fluid [12].…”

Section: Current Pharmaceutical Technologies Of Grddsmentioning

confidence: 99%

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Current State and Future Perspectives on Gastroretentive Drug Delivery Systems

et al. 2019

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In recent years, many attempts have been made to enhance the drug bioavailability and therapeutic effectiveness of oral dosage forms. In this context, various gastroretentive drug delivery systems (GRDDS) have been used to improve the therapeutic efficacy of drugs that have a narrow absorption window, are unstable at alkaline pH, are soluble in acidic conditions, and are active locally in the stomach. In this review, we discuss the physiological state of the stomach and various factors that affect GRDDS. Recently applied gastrointestinal technologies such as expandable, superporous hydrogel; bio/mucoadhesive, magnetic, ion-exchange resin; and low- and high-density-systems have also been examined along with their merits and demerits. The significance of in vitro and in vivo evaluation parameters of various GRDDS is summarized along with their applications. Moreover, future perspectives on this technology are discussed to minimize the gastric emptying rate in both the fasted and fed states. Overall, this review may inform and guide formulation scientists in designing the GRDDS.

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“…Various types of GRDDS with different gastroretentive mechanisms have been investigated, such as floating [4], high-density [5], muco-adhesive [6], raft-forming [7], magnetic [8], and expandable systems [9]. The most extensively explored types of GRDDS are floating or expandable systems.…”

Section: Introductionmentioning

confidence: 99%

Mechanically Robust Gastroretentive Drug-Delivery Systems Capable of Controlling Dissolution Behaviors of Coground β-Lapachone

Kim

Lee

et al. 2019

Pharmaceutics

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In this study, we aimed to design a highly swellable and mechanically robust matrix tablet (SMT) as a gastroretentive drug-delivery system (GRDDS) capable of improving the dissolution behavior of β-lapachone with low aqueous solubility. For the preparation of SMTs, the cogrinding technique and freeze–thaw method were used to disperse β-lapachone in SMTs in an amorphous state and to enhance the swelling and mechanical properties of SMTs, respectively. As a result, the crystallinity of coground β-lapachone incorporated in the SMTs was found to be considerably decreased; thereby, the dissolution rates of the drug in a simulated gastric fluid could be substantially increased. The SMTs of β-lapachone also demonstrated significantly enhanced swelling and mechanical properties compared to those of a marketed product. The reason for this might be because the physically crosslinked polymeric networks with a porous structure that were formed in SMTs through the freeze–thaw method. In addition, β-lapachone was gradually released from the SMTs in 6 h. Therefore, SMTs of β-lapachone developed in this study could be used as GRDDS with appropriate swelling and mechanical properties for improving the dissolution behavior of hydrophobic drugs such as β-lapachone.

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Gastroretentive raft liquid delivery system as a new approach to release extension for carrier-mediated drug

Cited by 40 publications

References 28 publications

In-Depth Study into Polymeric Materials in Low-Density Gastroretentive Formulations

In-Depth Study into Polymeric Materials in Low-Density Gastroretentive Formulations

Current State and Future Perspectives on Gastroretentive Drug Delivery Systems

Mechanically Robust Gastroretentive Drug-Delivery Systems Capable of Controlling Dissolution Behaviors of Coground β-Lapachone

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