Gastroretentive extended release of metformin from methacrylamide-g-gellan and tamarind seed gum composite matrix

Priyadarshini, Rosy; Nandi, Gouranga; Changder, Abhijit; Chowdhury, Sailee; Chakraborty, Sudipta; Ghosh, L. K.

doi:10.1016/j.carbpol.2015.10.054

Cited by 40 publications

(14 citation statements)

References 21 publications

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“…The application of experimental design is to obtain the maximum information with the minimum number of experiments. [17] The objective of this study is to develop GRDDS tablet of simvastatin. For this purpose, optimization study was conducted by using 3 2 factorial design layout of batches shown in Table 2.…”

Section: Experimental Designmentioning

confidence: 99%

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Untitled

Nawaj¹

2017

AJP

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Aim: The objectives of this investigation were to develop gastroretentive floating bioadhesive drug delivery for simvastatin to increase gastric residence time and reduce the dose frequency. To explore Badams gum's sticking property in floating bioadhesive drug delivery of simvastatin. Materials and Methods: Floating bioadhesive tablet was formulated with Badam gum and hydroxypropyl methylcellulose (HPMC) K 15 M polymers, sodium bicarbonate, and citric acid as the gas generating agents to reduce floating lag time. Tablets were prepared by direct compression method. Optimization study was conducted using 3 2 factorial design. The concentration of polymers was considered as independent variables whereas swelling index, bioadhesive strength and % drug release at 10 h, of the tablets were utilized as dependent variables. Results and Discussions: Preformulation study suggests powders blends shows acceptable flow properties. Simvastatin floating-bioadhesive tablet found to be good without chipping, capping, and sticking. Comparing all the formulations, A5 optimized formulation exhibited 98.10 ± 2.10% of drug release in 12 h, floating lag time of 34 ± 3 s, with appropriate bioadhesive property, and total floating time of over 12 h. It was observed that increasing percentage of polymer in formulation the drug release decreased. Developed formulations were stable during stability studies. Conclusion: Based on these findings, it was concluded that Badam gum can be used as a bioadhesive as well as release retarding polymer for the floating bioadhesive dosage form of other drugs.

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Section: Experimental Designmentioning

confidence: 99%

“…[16] Besides, simvastatin undergo extensive first-pass metabolism in the liver and hence, the availability of the drug to the general circulation is very low (below 5%). [17] Therefore, GRDDS might be advantageous for simvastatin. [18] Natural polysaccharides are extensively used for development of solid dosage form.…”

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confidence: 99%

Untitled

Nawaj¹

2017

AJP

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“…In the past couple of decades variety of strategies of gastroretentive drug delivery systems have been reported such as effervescent 1-3 , non-effervescent 4,5 , low density 6-8 , high density 9,7 , raft formed 10,11 , expandable 12,13 , in situ gelling 14,15 , mucoadhesive [16][17][18] , gastroretentive drug delivery systems in the form of capsules [19][20][21] , bi-layer tablets 22,23 , microspheres 24,25 , granules 26 , pellets [27][28][29] and beads 30,31 . Although the floating system has been generally designed using gas generators (e.g.…”

Section: Introductionmentioning

confidence: 99%

Formulation development and evaluation of a novel bi-dependent clarithromycin gastroretentive drug delivery system using Box-Behnken design

Malladi

Jukanti²

2016

Journal of Drug Delivery Science and Technology

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“…Besides being able to continually and sustainably deliver drugs to the small intestinal absorption window, the improvements provided from gastroretentive systems include achieving a greater and prolonged therapeutic effect and thus reducing the frequency of administration periods, and providing a more effective treatment of local stomach disorders (Chen et al, 2010). Thereby, various approaches, such as floating, bioadhesive and swelling and expanding systems have been developed to increase the gastric retention time of dosage forms (Rajab et al, 2014;Ferrari et al, 2014;Lemieux, Gosselin, Mateescu, 2015;Priyadarshini et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Floating ability and drug release evaluation of gastroretentive microparticles system containing metronidazole obtained by spray drying

Nohemann

Almeida

Ferrari

2017

Braz. J. Pharm. Sci.

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Gastroretentive floating microparticles were developed and evaluated for the controlled metronidazole delivery for treatment of gastric disease. Floating microparticles, varying in proportions of chitosan and hydroxypropyl methylcellulose or ethylcellulose, were obtained by spray drying. Floating microparticles were characterized by physicochemical and in vitro studies, according to their floating ability and drug delivery. Microparticles presented mean diameter from 1.05 to 2.20 µm. The infrared spectroscopy confirmed the drug encapsulation and showed no chemical linkage between microparticles components. X-ray diffraction showed changes in the drug`s solid state, from crystalline to amorphous, indicating partial drug encapsulation, due to the presence of some crystalline peaks of metronidazole in microparticles. All microparticles floated immediately in contact of simulated gastric fluid and both floating and drug release profiles were dependent of microparticles composition. Microparticles samples constituted by chitosan and hydroxypropyl methylcellulose revealed the best relationship between floating duration and drug release, remaining floating during the occurrence of the drug release, ideal condition for the floating gastroretentive systems.Uniterms: Floating microparticle. Chitosan. Ethylcellulose. Hydroxypropyl methylcellulose. Controlled drug delivery.

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Gastroretentive extended release of metformin from methacrylamide-g-gellan and tamarind seed gum composite matrix

Cited by 40 publications

References 21 publications

Untitled

Untitled

Formulation development and evaluation of a novel bi-dependent clarithromycin gastroretentive drug delivery system using Box-Behnken design

Floating ability and drug release evaluation of gastroretentive microparticles system containing metronidazole obtained by spray drying

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