Gastroretentive Drug Delivery System of Famotidine: Formulation and In Vitro Evaluation of Oil Entrapped Calcium Pectinate Gel Beads

Satheeshababu, B K

doi:10.4172/pharmaceutical-sciences.1000104

Cited by 4 publications

(3 citation statements)

References 5 publications

(8 reference statements)

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“…The presence of these polymers proved to be essential in achieving sustained drug release. Cod liver oil was incorporated to enhance the buoyancy of the systems and the formulations showed the ability to float over the gastric content for more than 24 h [124].…”

Section: Pectin Beadsmentioning

confidence: 99%

In-Depth Study into Polymeric Materials in Low-Density Gastroretentive Formulations

et al. 2020

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The extensive use of oral dosage forms for the treatment of diseases may be linked to deficient pharmacokinetic properties. In some cases the drug is barely soluble; in others, the rapid transit of the formulation through the gastrointestinal tract (GIT) makes it difficult to achieve therapeutic levels in the organism; moreover, some drugs must act locally due to a gastric pathology, but the time they remain in the stomach is short. The use of formulations capable of improving all these parameters, as well as increasing the resident time in the stomach, has been the target of numerous research works, with low-density systems being the most promising and widely explored, however, there is further scope to improve these systems. There are a vast variety of polymeric materials used in low-density gastroretentive systems and a number of methods to improve the bioavailability of the drugs. This works aims to expedite the development of breakthrough approaches by providing an in-depth understanding of the polymeric materials currently used, both natural and synthetic, their properties, advantages, and drawbacks.

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Section: Pectin Beadsmentioning

confidence: 99%

In-Depth Study into Polymeric Materials in Low-Density Gastroretentive Formulations

et al. 2020

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“…For example, the bioavailability of ofloxacin was improved up to 97.55 % compared with 53.90 % for the marketed product of ofloxacin (Zanocin ® ), when designing in ofloxacin modified release gastroretentive formulations by using different polymers as HPLC, psyllium husk, crospovidone, and its combinations [37]. Famotidine has been prepared as gastric floating calcium pectinate beads; the formulations have the ability to float over the gastric content for more than 24 h, the prepared gel beads efficiently sustain famotidine release where; 94.39 % of drug content was released over 8h from the optimized formula compared with 100 % of the drug was released over a period less than 3 h from famotidine conventional tablets [38].…”

Section: Ibrahim Et Almentioning

confidence: 99%

Gastro-retentive oral drug delivery systems: a promising approach for narrow absorption window drugs

Ibrahim

Naguib

Sarhan

et al. 2019

Journal of advanced Biomedical and Pharmaceutical Sciences

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Drugs with a narrow absorption window (NAW) are those drugs that are absorbed from the first part of the gastrointestinal tract. Therefore, typical modified/sustained release formulations of those drugs cannot provide a true long-acting drug release. Once the dosage form has passed the absorption sites at the specific regions of the small intestine; the drug is no longer absorbed from the modified release dosage form and the bioavailability is adversely decreased. While there are many pharmacological classes such as centrally acting skeletal muscle relaxants, anti-parkinsonism drugs and anti-infective belong to NAW drugs and are required to be formulated in modified release dosage forms. Modified release dosage forms based on gastroretentive technologies could hold a promise. Such dosage forms aim to release drugs in the upper part of the gastrointestinal tract especially in the stomach in a controlled release manner that might provide sustained release characteristics without sacrificing much of total bioavailability. This review provides a critical appraisal of different technologies, polymers, candidate drugs for gastroretentive technologies.

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“…Buoyancy Studies: The time between the introduction of the FDDS into the medium and its buoyancy to the upper one third of the dissolution vessel (floating lag time) and the time for which the formulation constantly floated on the surface of the medium (floating duration) were measured simultaneously as a part of dissolution studies by visual observation 6 .…”

Section: Preparation Of Floating Zinc Pectinate Beadsmentioning

confidence: 99%

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2018

IJPSR

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Floating Drug delivery systems are designed to prolong the gastric residence time after oral administration. Ofloxacin is an antibacterial fluoroquinolone, widely prescribed in gastric and duodenal ulcers. It exhibits pH dependent solubility, more soluble in acidic pH and slightly soluble in neutral or alkaline pH. Precipitation of the drug occurs in the intestine, which adversely affects the absorption in the lower sections of the intestine. So there is a need for systems that reside in the stomach over a relatively long period and release the active compound in a sustained manner. The aim of the present study was to develop a delivery system wherein the retention of Ofloxacin could be achieved for increasing local action in the gastric region against Helicobacter pylori, with the development of rice bran oil entrapped zinc pectinate beads containing Ofloxacin. Various formulations of floating beads of Ofloxacin were developed using polymers like Low Methoxy Pectin alone and in combination with rate controlling polymers such as Gellan Gum, Karaya Gum and Xanthan Gum. The beads were prepared by emulsion gelation method. Rice bran oil was used to impart buoyancy to the beads due to its low density. The beads were spherical in nature and beads formulated with a mixture of Low Methoxy Pectin and Gellan Gum showed the highest drug content and drug entrapment. The buoyancy studies on the beads proved that a minimum of 25% w/w of rice bran oil was required to impart satisfactory buoyancy to the beads.

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Gastroretentive Drug Delivery System of Famotidine: Formulation and In Vitro Evaluation of Oil Entrapped Calcium Pectinate Gel Beads

Cited by 4 publications

References 5 publications

In-Depth Study into Polymeric Materials in Low-Density Gastroretentive Formulations

In-Depth Study into Polymeric Materials in Low-Density Gastroretentive Formulations

Gastro-retentive oral drug delivery systems: a promising approach for narrow absorption window drugs

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