Gastroretentive Accordion Pill: Enhancement of riboflavin bioavailability in humans

Kagan, Leonid; Lapidot, Noa; Afargan, Michel; Kirmayer, David; Moor, E; Mardor, Yael; Friedman, Michael; Hoffman, Amnon

doi:10.1016/j.jconrel.2006.03.022

Cited by 66 publications

(33 citation statements)

References 22 publications

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“…In the stomach, the carrier is dissolved and the GRDF unfolds or opens out to achieve extended configuration. The storage should maintain unfoldable properties for extended time spans (Kagan et al, 2006).…”

Section: Swelling and Expandable Systemsmentioning

confidence: 99%

Gastroretentive dosage forms: A review with special emphasis on floating drug delivery systems

et al. 2010

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Section: Swelling and Expandable Systemsmentioning

confidence: 99%

Gastroretentive dosage forms: A review with special emphasis on floating drug delivery systems

et al. 2010

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“…For swelling tablets, the forces calculated in this manuscript could be used as a guideline in designing tablets with a sufficiently high compressive strength to overcome the gastric-emptying forces when swollen. Similarly, for unfolding films such as the Accordian Pill™, gastricemptying forces can be used to inform the minimum bending modulus of the unfolded film necessary for gastric retention (26).…”

Section: Resultsmentioning

confidence: 99%

Understanding gastric forces calculated from high-resolution pill tracking

Laulicht¹,

Tripathi

Schlageter³

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

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Although other methods exist for monitoring gastrointestinal motility and contractility, this study exclusively provides direct and quantitative measurements of the forces experienced by an orally ingested pill. We report motive forces and torques calculated from real-time, in vivo measurements of the movement of a magnetic pill in the stomachs of fasted and fed humans. Threedimensional net force and two-dimensional net torque vectors as a function of time data during gastric residence are evaluated using instantaneous translational and rotational position data. Additionally, the net force calculations described can be applied to highresolution pill tracking acquired by any modality. The fraction of time pills experience ranges of forces and torques are analyzed and correlate with the physiological phases of gastric digestion. We also report the maximum forces and torques experienced in vivo by pills as a quantitative measure of the amount of force pills experience during the muscular contractions leading to gastric emptying. Results calculated from human data are compared with small and large animal models with a translational research focus. The reported magnitude and direction of gastric forces experienced by pills in healthy stomachs serves as a baseline for comparison with pathophysiological states. Of clinical significance, the directionality associated with force vector data may be useful in determining the muscle groups associated with gastrointestinal dysmotility. Additionally, the quantitative comparison between human and animal models improves insight into comparative gastric contractility that will aid rational pill design and provide a quantitative framework for interpreting gastroretentive oral formulation test results. drug delivery | gastric retention | gastrointestinal biophysics | pill science

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“…Hoffman and colleagues , Klausner et al, 2003, Kagan et al, 2006 also developed an expanding system that can be placed within a hard gelatin capsule for administration. Their device shown in Fig.…”

Section: Expandable Systemsmentioning

confidence: 99%