Gastroprotective flavonoid constituents from Oroxylum indicum Vent.

Babu, T. Hari; Manjulatha, K.; Kumar, Gopinatha Suresh; Hymavathi, A.; Tiwari, Ashok Kumar; Purohit, Muraleedhar; Rao, J. Madhusudana; Babu, K. Suresh

doi:10.1016/j.bmcl.2009.11.024

Cited by 80 publications

(22 citation statements)

References 13 publications

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“…Medicinal plants represent an alternative for treating ulcers. Indeed, an important basis for the discovery and development of new drugs has been the isolation of some of the metabolites derived from plants and employed in traditional medicine (Hari Babu et al, ). We recently reported the protective activity of Calea urticifolia against ethanol‐induced gastric lesions in rats.…”

Section: Introductionmentioning

confidence: 99%

Gastroprotective effect of calealactone B: Lack of involvement of prostaglandins, nitric oxide and sulfhydryls

Sánchez-Mendoza

López-Lorenzo

Matus-Meza

et al. 2017

Drug Development Research

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Hit, Lead & Candidate Discovery The gastroprotective effect of calealactone B, isolated from Calea urticifolia was assessed in an ethanol-induced model of gastric lesioning. The possible involvement of prostaglandins, nitric oxide (NO) and sulfhydryl groups in the mechanism of action of calealactone B was also assessed. Calealactone B inhibited ethanol-induced gastric injuries with a maximal effect (95.3 ± 2.6%) at 30 mg kg . A similar value was obtained at 10 mg kg (83.5 ± 7.7%). Meanwhile, the reference anti-ulcer drug, carbenoxolone, an 11β-hydroxysteroid dehydrogenase (11β-HSD) inhibitor administered at 30 mg kg showed 63.5 ± 9.4% gastroprotection. Hence, calealactone B was more potent than carbenoxolone. Pretreatment with indomethacin, L-NAME or NEM did not reverse the effects of calealactone B, indicating that prostaglandins, NO and sulfhydryl compounds do not participate in its mechanism of action.

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Section: Introductionmentioning

confidence: 99%

Gastroprotective effect of calealactone B: Lack of involvement of prostaglandins, nitric oxide and sulfhydryls

Sánchez-Mendoza

López-Lorenzo

Matus-Meza

et al. 2017

Drug Development Research

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“…The drugs currently used in the treatment of gastric ulcers are anti-acids, anticholinergics, proton pump inhibitors and H 2 -receptor antagonists. However, there are innumerable adverse effects caused by these allopathic medicines [ 2 ], indicating the need for more effective and safer antigastric ulcer agents with less side effects. In this context, metabolites derived from plants used in traditional medicine have provided an important basis for the discovery and development of modern therapeutic drugs [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Bioassay-Guided Isolation of an Anti-Ulcer Compound, Tagitinin C, from Tithonia diversifolia: Role of Nitric Oxide, Prostaglandins and Sulfhydryls

Sánchez-Mendoza

Reyes-Ramírez²,

Antonio³

et al. 2011

Molecules

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Tithonia diversifolia is a medicinal plant from the Municipality of Suchiapa, Chiapas, Mexico, that according to local folk medicine is considered useful in the treatment of gastric ulcers. The aim of the present study was to investigate the gastroprotective activity of T. diversifolia by using an ethanol-induced gastric ulcer experimental model in male Wistar rats. The results showed that T. diversifolia had gastroprotective activity, and that the dichloromethane extract had the highest protective activity (close to 90% when using doses between 10 to 100 mg/kg), and that further the compound tagitinin C isolated from this extract was the main active gastroprotective agent. Rats treated with tagitinin C suspended in Tween 80 at 1, 3, 10 and 30 mg/kg showed 37.7, 70.1, 100, and 100% gastroprotection, respectively. The effect elicited by tagitinin C (30 mg/kg) was not attenuated by pretreatment with either NG-nitro-L-arginine methyl ester (70 mg/kg, i.p.), a nitric oxide (NO) synthase inhibitor, N-ethylmaleimide (10 mg/kg, s.c.), a blocker of sulfhydryl groups, or indomethacin (10 mg/kg, s.c.), a blocker of prostaglandin synthesis, which suggests that the gastroprotective mechanism of action of this sesquiterpene lactone does not involve NO, sulfhydryl groups or prostaglandins.

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“…In conclusion the antiulcer properties of the extract may be attributed to the flavonoids content that are present in it. [38]…”

Section: Experimentally Studied Plants Possessing Phenolic Compoundsmentioning

confidence: 99%

Role of phenolic compounds in peptic ulcer: An overview

2011

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Peptic ulcer is the most common gastrointestinal tract (GIT) disorder in clinical practice, which affects approximately 5-10% of the people during their life. The use of herbal drugs for the prevention and treatment of various diseases is constantly developing throughout the world. This is particularly true with regard to phenolic compounds that probably constitute the largest group of plants secondary metabolites. Phenolic compounds have attracted special attention due to their health-promoting characteristics. In the past ten years a large number of the studies have been carried out on the effects of phenolic compounds on human health. Many studies have been carried out that strongly support the contribution of polyphenols to the prevention of cardiovascular diseases, cancer, osteoporosis, neurodegenerative diseases, and diabetes mellitus, and suggest a role in the prevention of peptic ulcer. Polyphenols display a number of pharmacological properties in the GIT area, acting as antisecretory, cytoprotective, and antioxidant agents. The antioxidant properties of phenolic compounds have been widely studied, but it has become clear that their mechanisms of action go beyond the modulation of oxidative stress. Various polyphenolic compounds have been reported for their anti-ulcerogenic activity with a good level of gastric protection. Besides their action as gastroprotective, these phenolic compounds can be an alternative for the treatment of gastric ulcers. Therefore, considering the important role of polyphenolic compounds in the prevention or reduction of gastric lesions induced by different ulcerogenic agents, in this review, we have summarized the literature on some potent antiulcer plants, such as, Oroxylum indicum, Zingiber officinale, Olea europaea L., Foeniculum vulgare, Alchornea glandulosa, Tephrosia purpurea, and so on, containing phenolic compounds, namely, baicalein, cinnamic acid, oleuropein, rutin, quercetin, and tephrosin, respectively, as active constituents.

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Gastroprotective flavonoid constituents from Oroxylum indicum Vent.

Cited by 80 publications

References 13 publications

Gastroprotective effect of calealactone B: Lack of involvement of prostaglandins, nitric oxide and sulfhydryls

Gastroprotective effect of calealactone B: Lack of involvement of prostaglandins, nitric oxide and sulfhydryls

Bioassay-Guided Isolation of an Anti-Ulcer Compound, Tagitinin C, from Tithonia diversifolia: Role of Nitric Oxide, Prostaglandins and Sulfhydryls

Role of phenolic compounds in peptic ulcer: An overview

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