Gastroprotective effects of Pikad Tri-phol-sa-mut-than herbal remedy on multiple gastric ulcer models in rats

Tan, Bing; Chiranthanut, Natthakarn; Chansakaow, Sunee; Sireeratawong, Seewaboon; Khonsung, Parirat; Nimlamool, Wutigri; Takuathung, Mingkwan Na; Lertprasertsuke, Nirush

doi:10.1016/j.heliyon.2023.e19297

Cited by 3 publications

(1 citation statement)

References 75 publications

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“…However, long-term use of NSAIDs is associated with significant gastrointestinal injury, specifically leading to the development of gastric lesions [3]. While NSAIDs are an important cause of ulcers, factors such as stress, smoking, alcoholism, frequent and indiscriminate use of medications, infection with Helicobacter pylori, heredity, increase in gastric acid secretion, and excessive reactive oxygen formation (ROS), among others, can play different roles in the genesis of the disease, and are therefore considered important risk factors for the development of gastric ulcers [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Unravelling the Gastroprotective Potential of Kefir: Exploring Antioxidant Effects in Preventing Gastric Ulcers

Côco,

Aires,

Carvalho

et al. 2023

Cells

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The present study was conducted to evaluate the protective effect of milk kefir against NSAID-induced gastric ulcers. Male Swiss mice were divided into three groups: control (Vehicle; UHT milk at a dose of 0.3 mL/100 g), proton pump inhibitor (PPI; lansoprazole 30 mg/kg), and 4% milk kefir (Kefir; 0.3 mL/100 g). After 14 days of treatment, gastric ulcer was induced by oral administration of indomethacin (40 mg/kg). Reactive oxygen species (ROS), nitric oxide (NO), DNA content, cellular apoptosis, IL-10 and TNF-α levels, and myeloperoxidase (MPO) enzyme activity were determined. The interaction networks between NADPH oxidase 2 and kefir peptides 1–35 were determined using the Residue Interaction Network Generator (RING) webserver. Pretreatment with kefir for 14 days prevented gastric lesions. In addition, kefir administration reduced ROS production, DNA fragmentation, apoptosis, and TNF-α systemic levels. Simultaneously, kefir increased NO bioavailability in gastric cells and IL-10 systemic levels. A total of 35 kefir peptides showed affinity with NADPH oxidase 2. These findings suggest that the gastroprotective effect of kefir is due to its antioxidant and anti-inflammatory properties. Kefir could be a promising natural therapy for gastric ulcers, opening new perspectives for future research.

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Section: Introductionmentioning

confidence: 99%

Unravelling the Gastroprotective Potential of Kefir: Exploring Antioxidant Effects in Preventing Gastric Ulcers

Côco,

Aires,

Carvalho

et al. 2023

Cells

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A comprehensive review on phytochemicals as potential therapeutic agents for stress-induced gastric ulcer

Shahzad,

Ibrahim,

Alzahrani

et al. 2024

J.Umm Al-Qura Univ. Appll. Sci.

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Gastric ulcers are the most common chronic gastrointestinal tract disorders, marked by an inflamed break of the mucus membrane covering the alimentary tract. According to recent research, stress-induced ulcers are widespread in our society. A stress ulcer is a mucosal defect that may become complicated due to upper gastrointestinal tract bleeding. The underlying cause of this condition is pH. Physiological stress leads to severe sickness by triggering the excessive secretion of peptic juices or gastric acid. There is a never-ending quest for safe and affordable medication for this disorder. Nature offers many medicinal plants that can be used to treat a wide range of human ailments. Due to their relatively harmless and comparatively free of harmful effects, health-promoting features, pharmacological practices, and affordability to common people to regulate various diseases, medicinal plants, and herbal preparations are gaining a lot of interest in scientific communities these days. Many studies have recently been performed to classify extracts and their constituents that may have a therapeutic effect on peptic ulcers. Therefore, this review aims to address the molecular mechanisms and pharmacological effects of various phytochemicals related to stress-induced gastric ulcers. Combining phytochemical constituents with modern drugs and treatment methods can lead to the development of therapeutic drugs for gastric ulcers. Gastric ulcers and other related diseases may be treated permanently with this approach.

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Characterization of the antioxidant activity, identified free radical-relieving components by LC/QTOF/MS and acute oral toxicity studies of Tri-Tharn-Thip tea

Sanpinit,

Goon,

Wetchakul

2024

Journal of Agriculture and Food Research

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Gastroprotective effects of Pikad Tri-phol-sa-mut-than herbal remedy on multiple gastric ulcer models in rats

Cited by 3 publications

References 75 publications

Unravelling the Gastroprotective Potential of Kefir: Exploring Antioxidant Effects in Preventing Gastric Ulcers

Unravelling the Gastroprotective Potential of Kefir: Exploring Antioxidant Effects in Preventing Gastric Ulcers

A comprehensive review on phytochemicals as potential therapeutic agents for stress-induced gastric ulcer

Characterization of the antioxidant activity, identified free radical-relieving components by LC/QTOF/MS and acute oral toxicity studies of Tri-Tharn-Thip tea

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