Gastroprotective effect of vitamin U in D‐galactosamine‐induced hepatotoxicity

Abstract

Galactosamine (GalN) is a well‐known agent for inducing viral hepatitis models in rodents, but it can cause toxicity on different organs. Vitamin U (Vit U) has been proved as a powerful antioxidant on many toxicity models. The present study was designed to investigate the protective effects of Vit U on GalN‐induced stomach injury. Rats were divided into four groups as follows: control (group I), Vit U given animals (50 mg/kg per day; group II), GalN administered animals (500 mg/kg at a single dose; group III), GalN + Vit U given animals (at the same dose and time, group IV). At the end of the 3rd day, animals were killed, and stomach tissues were taken. They were homogenized and centrifuged. In comparison to the control group, glutathione, total antioxidant capacity levels, catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase, glutathione‐S‐transferase, and Na+/K+‐ATPase activities of GalN group were found to be decreased. On the contrary, lipid peroxidation, advanced oxidized protein products, hexose‐hexosamine, fucose, sialic acid, reactive oxygen species levels, as well as the activities of myeloperoxidase, xanthine oxidase, and lactate dehydrogenase were elevated. Administration of Vit U reversed these abnormalities in the GalN group. It can be concluded that Vit U exerts its unique antioxidant effect and prevents GalN‐induced gastric damage.

Oxidative Brain Injury Induced by Amiodarone in Rats: Protective Effect of S‐Methyl Methionine Sulfonium Chloride

“…MMSC administration increased this activity in AMD+MMSC group as compared to AMD group. This effect may be due to membrane repairing and antioxidant effects of MMSC, as earlier indicated by Rácz et al, 47 Turkyilmaz and Yanardag, 70 and Topaloglu et al, 18 respectively.…”

“…6,[12][13][14][15][16] In addition, the most amazing and breath-taking attention of this sulfur containing compound is its antioxidant property, which has been proven by many researchers. [17][18][19] In the current study, the protective effects of MMSC on amiodarone induced brain damage was investigated.…”

In vitro trypsin inhibitory activities of some plant and fruit extracts and chemical compounds

“…Vitamin U, also known as S-methyl methionine sulfonium chloride, is a methionine derivative that has a powerful antioxidant effect. It has protective effects on various toxicity models, regulative effects on antioxidant systems and enzymes, and gastroprotective effects (Turkyilmaz et al, 2019;Topaloglu et al, 2022). According to the study of Dağsuyu and Yanardağ (Dağsuyu & Yanardağ, 2021), sulfur compounds, including Vitamin U, had different trypsin inhibitory activities.…”

Purification and characterization of thioredoxin reductase enzyme from commercial Spirulina platensis tablets by affinity chromatography and investigation of the effects of some chemicals and drugs on enzyme activity

“…Due to its sulfonium functional group, this cation is an intermediate in several metabolic processes 39 . In some in vitro studies, vitamin U exhibited protective effect, such as in pentylenetetrazole‐induced brain damage, 40 d ‐galactosamine‐induced hepatotoxicity, 41 valproic acid‐induced lens injury, 42 and in oxidative brain and cerebellum damage induced by d ‐galactosamine 43 . In the present research, vitamin B 6 exhibited the lowest IC 50 value for TrxR inhibition activity among tested vitamins.…”