Gastroprotective effect of the ethanolic extract of Parkia platycephala Benth. leaves against acute gastric lesion models in rodents

Abstract

Parkia platycephala Benth. (Leguminosae -Mimosoideae), popularly known as "visgueira", fava bean tree or "fava-de-bolota", is widely found in the Northern and Northeastern regions of Brazil. Its pods are used as cattle food supplement in the drought period. Compounds with a gastroprotective activity were obtained from the genus Parkia. Therefore, this study aimed at investigating the gastroprotective effect of the ethanolic extract of Parkia platycephala Benth. leaves (Pp-EtOH), as well as evaluating its possible mechanisms of action in experimental ulcer induction models. Lesions were induced by absolute ethanol, ethanol-HCl, ischemiareperfusion and indomethacin in rodents. Pp-EtOH showed a protective effect in the lesion models (66, 48 and 52 %, respectively), but it was not able to protect gastric mucosa against indomethacin-induced lesions. Results show a possible participation of the NOsynthase pathway in the gastroprotection and an antioxidant activity, by the increase of the catalase activity. The participation of prostaglandins and potassium channels sensitive to ATP in the gastroprotective effect of Pp-EtOH seems less likely to occur. More comprehensive studies, therefore, should be carried out to elucidate the antiulcerative effects of this promising natural product against this gastrointestinal disorder.

Gastro-protective effect of Ziziphus abyssinica root extracts in ethanol-induced acute ulcer in Wistar rats

“…This shows that the plant is safe and has no toxicity when administered orally up to 5 g/kg. The absence of acute toxicity in rats ensured a good margin of safety for the doses of this extract in the experimental protocols of gastric lesions, as no mortality recorded for each animal [10][11][12].…”

Characterization of Proanthocyanidins from Parkia biglobosa (Jacq.) G. Don. (Fabaceae) by Flow Injection Analysis — Electrospray Ionization Ion Trap Tandem Mass Spectrometry and Liquid Chromatography/Electrospray Ionization Mass Spectrometry

“…Precursor ions at m/z 577, 593 and 609, corresponding to catechin dimers, were attributed to (epi)catechin-(epi)catechin (8)(9)(10)(11) [19], (epi)catechin-(epi)gallocatechin (12)(13)(14) and (epi)gallocatechin-(epi)gallocatechin (15)(16) [37], respectively.…”

“…The fermented seed (known as dawadawa or soumbala) is a popular, protein-rich condiment in many Western African countries [3,4]. Studies with species of the genus Parkia showed that most of them have antioxidant [5], antimicrobial [6,7], gastroprotective [8] and some antihypertensive effects [9]. Previous phytochemical investigations of P. biglobosa reported that sterols, triterpenes [10], catechins and phenolic derivatives could be isolated from the bark [11], and fatty acids from the seed oil of this species [12].…”

Comparative Evaluation of the Gastroprotective Effect of L-Carnitine and Omeprazole on Ethanol-Induced Gastric Ulcer in Male Albino Wister Rats

“…Aggressive factors which promote gastric mucosal injury include gastric hydrochloride (HCl)(3), mucosal hypoperfusion,(4), free oxygen radicals (5), and ethanol (6), etc. The experimental model of ethanol-induced gastric mucosal damage in rats is widely used to assess the protective and healing activity of many drugs in ulcer studies (7), due to its ability to reduce endogenous NO level and blood flow in gastric mucosa, which leads to a serious hemorrhagic necrosis and consequently depletes gastric mucus constituents, elevated pepsin secretion, loss of H+ and histamine into the lumen (8). Not only alcohol causes direct gastric mucosal damage, its abuse is also associated with development of gastric diseases such as gastritis and even gastric cancer (9).…”