Gastroprotective effect of simvastatin against indomethacin-induced gastric ulcer in rats: Role of nitric oxide and prostaglandins

Heeba, Gehan H.; Hassan, Magdy K.; Amin, Rauuia S.

doi:10.1016/j.ejphar.2009.02.008

Cited by 69 publications

(70 citation statements)

References 37 publications

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“…Catalase is a highly reactive enzyme that reacts with H2O2 to form water and molecular oxygen [76][77][78]. SOD plays an important role in preventing gastric ulcer by catalyzing the breakdown of highly reactive radical superoxide (O 2-) into oxygen and hydrogen peroxide [79,80]. In agreement with the report of [81,15] the inhibition of the antioxidant enzymes, SOD and GST following SGU in the present study may be due to the enhancement of the lipid peroxidation which, inhibit protein synthesis and consequently the activities of certain enzymes.…”

Section: Discussionmentioning

confidence: 99%

Antiulcerogenic Efficacy of Ethanolic Extract of Vitis Vinifera Leaves in Rats

Sayed

Fahmy

Soliman

et al. 2016

Int J Pharm Pharm Sci

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Objective: The ethanolic extract of Vitis vinifera leaves (VVE) (500 mg/kg body weight), ranitidine (50 mg/kg body weight) and both of them were tested for their gastroprotective and curative effects against the incidence of peptic ulcer. Methods:The antiulcer effects of VVE were investigated using a combination of indomethacin and cold-stress for 2h. To ascertain the mechanism of action of VVE, its protective and curative effects were studied on gastric volume, gastric juice acidity, ulcer index and malondialdehyde (MDA), glutathione (GSH), catalase (CAT), glutathione-S-transferase (GST), superoxide dismutase (SOD), nitric oxide (NO) activities of both stomach and duodenum of rats. Moreover, histopathological effects on stomach and duodenum were determined. Results:The antioxidant activity of VVE was demonstrated using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) test. VVE was found to reduce the ulcer index, gastric volume and the level of gastric juice acidity. Also, VVE showed gastroprotective and curative activities mainly through improvement of antioxidant status and decreasing lipid peroxidation accompanied with amelioration of both stomach and duodenum architectures. Conclusion:The prophylactic and curative effects of VVE proved to be effective in preventing gastric and duodenal ulceration which may be probably due to its antioxidant and anti-acid secretory effects.

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Section: Discussionmentioning

confidence: 99%

Antiulcerogenic Efficacy of Ethanolic Extract of Vitis Vinifera Leaves in Rats

Sayed

Fahmy

Soliman

et al. 2016

Int J Pharm Pharm Sci

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“…A study by Tariq et al [18] demonstrated the gastric antisecretory and antiulcer effects of SIM in pylorus-ligated rats. SIM was also found to protect gastric mucosa from indomethacininduced ulceration via promoting gastric mucosal NO and prostaglandin E2 levels, stimulating gastric mucin release in addition to its direct antioxidant activity [19].…”

Section: Introductionmentioning

confidence: 99%

The effect of simvastatin pretreatment on stress-induced gastric ulcer in rats

Bulut

Kabayuka

Şenkal

et al. 2016

MMJ

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Objectives: This study aimed to elucidate the possible protective effect of simvastatin (SIM) pretreatment on stress-induced gastric ulcer in rats. Materials and Methods:Gastric ulcer was produced in Sprague-Dawley rats (250-300 g) by cold-restraint stress. SIM (10 mg/kg/day; per oral) or saline was administered for 21 days prior to stress. On day-21, a group of animals was treated with the non-selective nitric oxide synthase (NOS) inhibitor L-NAME (50 mg/kg; intraperitoneally) or the non-selective cyclooxygenase (COX) inhibitor indomethacin (Indo; 5 mg/kg; subcutaneously) prior to SIM. The stomachs were examined macroscopically and microscopically and stored for biochemical analyses. Results:The severity of the lesions of the stress group was decreased by SIM, but this was not altered significanty by L-NAME or Indo. Stress increased gastric myeloperoxidase activity comparised to control level (p<0.01); however, SIM did not cause a significant change on this parameter. Stress increased gastric chemiluminescence levels (p<0.001) which were reversed by SIM (p<0.001) and this effect continued in L-NAME-or Indotreated animals.Conclusion: SIM pretreatment of rats with cold-restraint stress provided protection against gastric lesion formation via supression of oxidants derived from sources other than neutrophils without the involvement of NOS and COX systems.Keywords: Ulcer, Nitric oxide synthase, Cyclooxygenase, Rat, Stress ÖZ Amaç: Bu çalışmada sıçanlarda stres ile uyarılan mide ülserinde simvastatin'in (SİM) olası koruyucu etkisini değerlendirmek amaçlanmıştır. Gereç ve Yöntem:Sprague-Dawley sıçanlarda (250-300 gr) soğuk-kısıtlama stres uygulaması ile mide ülseri oluşturuldu. Stres öncesi 21 gün süreyle SİM (10 mg/kg/day; oral yolla) veya fizyolojik tuzlu su (1 ml; oral yolla) uygulandı. Bir grup sıçan 21. günde SİM öncesi selektif olmayan nitrik oksit sentaz (NOS) inhibitörü L-NAME (50 mg/kg; intraperitoneal) veya selektif olmayan siklooksijenaz (COX) inhibitörü indometazin (İndo; 5 mg/kg; subkutan) verildi. Mideler makroskopik ve mikroskopik olarak incelendi ve biyokimyasal analizler için saklandı. Bulgular:Stres grubunda lezyonların şiddeti SİM ile azaldı ancak L-NAME veya İndo ile anlamlı bir değişiklik göstermedi. Stres mide miyeloperoksidaz aktivitesini kontrol düzeyine kıyasla artırdı (p<0.01); ancak, SİM bu parametre üzerinde anlamlı bir değişikliğe neden olmadı. Stres mide kemiluminisans düzeylerini artırdı (p<0.01); bu etki SİM ile geri döndürüldü (p<0.001); L-NAME veya İndo ile tedavi edilen hayvanlarda ise devam etti.Sonuç: Soğuk-kısıtlama stresine maruz bırakılan sıçanlara SIM öntedavisi mide lezyon oluşumunda NOS ve COX sistemlerinden ayrı mekanizmalarla nötrofil dışı hücrelerden kaynaklanan oksidanları baskılayarak koruma sağlamaktadır.

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“…It has both analgesic and anti-pyretic effects 9 . It has ability to cause the gastric ulcer by the production of free radicals, inducing lipid peroxidation, inhibition of prostaglandins and leukocytic infiltration 10 . E. prostrata is a small annual herb present all over the world.…”

Section: Introductionmentioning

confidence: 99%

Gastro Protective and Antioxidant Effect of Euphorbia Prostrata Against Indomethacin Induced Gastric Ulcers in Healthy Adult Male Albino Rabbits

Begum¹,

Aslam²,

Javed³

et al. 2014

Int. Res. J. Pharm.

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Euphorbia prostrate belongs to family Euphorbiaceae locally known as Doodhi is small annual herb. Current study was conducted to evaluate the gastro protective and antioxidant effectiveness of the aerial parts of E. prostrata in indomethacin induced ulcer in adult male albino rabbits. A total 36 mice were taken and divided into 6 equal groups. At day 0 and 14 of experiment the blood sample was collected from each animal and serum was separated from blood which was used for the determination of Total oxidant status (TOS), Total antioxidant capacity (TAC), catalase (CAT) and Malondialdehyde (MDA). At the end of the experiment, all of the rabbits were slaughtered. The gastric contents were collected to total acid output, gastric pH and gastric volume. To confirm the data results was subjected to one way analysis of variance (ANOVA). Results when compared with the extensive mucosal damage in the indomethacin trated group, gross evaluation revealed a marked protection of the gastric mucosa in the experimental groups, with significantly reduction in gastric pH, gastric volume and acid output. In these groups, CAT and TAC levels were significantly increased (P < 0.05) and while MDA and TOS significantly reduced (P < 0.05) which indicate reduction in gastric damage. In conclusion to these results E. prostrata has potent antioxidant properties at dose rate of 240 mg/kg and it is also very effective for the treatment of gastric ulcer at the same dose.

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Gastroprotective effect of simvastatin against indomethacin-induced gastric ulcer in rats: Role of nitric oxide and prostaglandins

Cited by 69 publications

References 37 publications

Antiulcerogenic Efficacy of Ethanolic Extract of Vitis Vinifera Leaves in Rats

Antiulcerogenic Efficacy of Ethanolic Extract of Vitis Vinifera Leaves in Rats

The effect of simvastatin pretreatment on stress-induced gastric ulcer in rats

Gastro Protective and Antioxidant Effect of Euphorbia Prostrata Against Indomethacin Induced Gastric Ulcers in Healthy Adult Male Albino Rabbits

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