Gastroprotective Effect of Mangiferin, a Xanthonoid from <i>Mangifera indica</i>, against Gastric Injury Induced by Ethanol and Indomethacin in Rodents

Carvalho, Ana Maria; Guedes, Marjorie; Souza, Antônia Queiroz Lima de; Trevisan, Maria Teresa; Lima, Alana Kelly Maia Macêdo Nobre de; Santos, Flávia Patrícia Sena Teixeira; Rao, Vietla

doi:10.1055/s-2007-993751

Cited by 20 publications

(25 citation statements)

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“…While studying the effect of different natural compounds with a diversified antiinflammatory role, Lima et al observed that the flower extract of mangiferin possess significant gastroprotective effect [159]. Later, Carvalho et al observed that intraduodenal exposure of mangiferin at a dose 30 mg/kg body weight significantly reduces the formation of gastric ulcer induced by ethanol and indomethacin [160]. In that study they have also hypothesized that owing to the anti-inflammtory action of mangiferin, it can act as an antiulerogenic agent in the experimental model system via the modulation of intracellular prostaglandin level.…”

Section: Anti-inflammatory Role Of Mangiferin Against Gastropathymentioning

confidence: 99%

Mangiferin: A xanthonoid with multipotent anti‐inflammatory potential

2016

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Over the last era, small molecules sourced from different plants have gained attention for their varied and long-term medicinal benefits. Their advantageous therapeutic effects in diverse pathological complications lead researchers to give an ever-increasing emphasis on them and discover their novel therapeutic potentials. Among these, the heat stable, xanthonoid group of organic molecules has gained special importance with distinctive regards to the bioactive molecule mangiferin due to its solubility in water. Mangiferin, a yellow polyphenol having C-glycosyl xanthone structure, is widely present in different edible sources like mango, and possesses numerous biological activities. Extensive research with this molecule shows its antioxidant, anti-inflammatory, antidiabetic, anticancer, antimicrobial, analgesic, and immunomodulatory properties. Thus, it provides protection against a wide range of physiological disorders. The C-glucosyl linkage and polyhydroxy groups in mangiferin's structure contribute essentially to its free radical-scavenging activity. Moreover, its ability in regulating various transcription factors like NF-κB, Nrf-2, etc. and modulating the expression of different proinflammatory signaling intermediates like tumor necrosis factor-α, COX-2, etc. contribute to its anti-inflammatory, anticancer, and antidiabetic potentials. In this comprehensive article, information has been provided about the sources, chemical structure, metabolism, and different biological activities of mangiferin with special emphasis on the underlying cellular signal transduction pathways. Insights into an in-depth assessment of mangiferin's anti-inflammatory therapeutic potential have also been discussed in detail. On an overall perspective, this review aims to stage mangiferin's diversified therapeutic applications and its emerging possibility as a promising drug in future based on its anti-inflammatory property. © 2016 BioFactors, 42(5):459-474, 2016.

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Section: Anti-inflammatory Role Of Mangiferin Against Gastropathymentioning

confidence: 99%

Mangiferin: A xanthonoid with multipotent anti‐inflammatory potential

2016

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“…There have been reports that MGF decreases glutamate-induced neurotoxicity and memory loss induced by scopolamine [23,27,39]. We previously demonstrated that MGF affords gastroprotection against absolute ethanol or indomethacin-induced gastric ulceration through an antioxidant mechanism [10]. Impaired antioxidant defenses are suggested to participate in the pathophysiology of schizophrenia and other neurodegenerative conditions.…”

Section: Introductionmentioning

confidence: 99%

Mangiferin ameliorates 6-hydroxydopamineinduced cytotoxicity and oxidative stress in ketamine model of schizophrenia

Rao

Carvalho

Trevisan

et al. 2012

Pharmacological Reports

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“…Some furoflavones (74)(75)(76)(77)(78)(79)(80)(81)(82)(83)(84)(85)(86)(87)(88), synthesized from the naturally occurring chromones visnagin (72) and khellin (73), exhibited gastroprotective activity in the ethanol damage model [77].…”

Section: Flavonoidsmentioning

confidence: 99%

Natural Products as Gastroprotective and Antiulcer Agents: Recent Developments

Tundis

Loizzo

Bonesi

et al. 2008

Natural Product Communications

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Peptic ulcer, one of the most common gastrointestinal diseases, is a chronic inflammatory disease characterized by ulceration in the regions of the upper gastrointestinal tract where parietal cells are found and where they secrete hydrochloric acid and pepsin. The anatomical sites where ulcer occurs commonly are stomach and duodenum, causing gastric and duodenal ulcer, respectively. Physiopathology of ulcer is due to an imbalance between aggressive factors, such as acid, pepsin, Helicobacter pylori and non-steroidal anti-inflammatory agents, and local mucosal defensive factors, such as mucus bicarbonate, blood flow and prostaglandins. Several drugs are widely used to prevent or treat gastro-duodenal ulcers. These include H 2-receptor antagonists, proton pump inhibitors and cytoprotectives. Due to problems associated with recurrence after treatment, there is therefore the need to seek alternative drug sources against ulcers. In recent years, a widespread search has been launched to identify new gastroprotective drugs from natural sources. The aim of the present review is to highlight the recent advances in current knowledge on natural products as gastroprotective and antiulcer agents and consider the future perspectives for the use of these compounds.

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Gastroprotective Effect of Mangiferin, a Xanthonoid from Mangifera indica, against Gastric Injury Induced by Ethanol and Indomethacin in Rodents

Cited by 20 publications

References 0 publications

Mangiferin: A xanthonoid with multipotent anti‐inflammatory potential

Mangiferin: A xanthonoid with multipotent anti‐inflammatory potential

Mangiferin ameliorates 6-hydroxydopamineinduced cytotoxicity and oxidative stress in ketamine model of schizophrenia

Natural Products as Gastroprotective and Antiulcer Agents: Recent Developments

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