Gastroprotective effect of Cissus sicyoides (Vitaceae): Involvement of microcirculation, endogenous sulfhydryls and nitric oxide

Ferreira, Mariana de Paula; Nishijima, Catarine Massucato; Seito, Leonardo Norobu; Dokkedal, Anne Lígia; Lopes-Ferreira, Mônica; Stasi, Luiz Cláudio Di; Vilegas, Wagner; Hiruma-Lima, Clélia Akiko

doi:10.1016/j.jep.2008.01.008

Cited by 27 publications

(13 citation statements)

References 22 publications

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“…Ferreira et al (2008) confirmed the gastroprotective action of the herb. Hernández (1651) wrote: "it quenches fevers".…”

Section: Internal Usesupporting

confidence: 53%

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Cissus verticillata (L.) Nicolson and C.E. Jarvis (Vitaceae): Its identification and usage in the sources from 16th to 19th century

Drobnik

Oliveira

2015

Journal of Ethnopharmacology

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“…Ferreira et al (2008) confirmed the gastroprotective action of the herb. Hernández (1651) wrote: "it quenches fevers".…”

Section: Internal Usesupporting

confidence: 53%

“…Later Barbosa et al (2002), Pepato et al (2003) and Viana et al (2004) proved that aqueous extracts from leaves had hypoglycaemic and anti-lipemic action. Also, methanolic extract is gastroprotective (Ferreira et al, 2008).…”

Section: Scientific Vernacular Names and Medicinal Valuementioning

confidence: 99%

Cissus verticillata (L.) Nicolson and C.E. Jarvis (Vitaceae): Its identification and usage in the sources from 16th to 19th century

Drobnik

Oliveira

2015

Journal of Ethnopharmacology

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“…In the HCl/ethanol-induced gastric ulceration model, HCl causes severe damage to gastric mucosa [26], whereas ethanol produces necrotic lesions by direct necrotizing action which in turn reduces defensive factors like the secretion of bicarbonate and production of mucus [27]. Ethanol-induced gastric lesions impaired gastric defensive factors such as mucus and mucosa circulation [28]. Ethanol causes necrotic lesions of the gastric mucosa in a multifactorial way.…”

Section: Discussionmentioning

confidence: 99%

Mechanisms of Gastroprotective Effects of Ethanolic Leaf Extract ofJasminum sambacagainst HCl/Ethanol-Induced Gastric Mucosal Injury in Rats

AlRashdi

Salama

Alkiyumi

et al. 2012

Evidence-Based Complementary and Alternative Medicine

108

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Jasminum sambacis used in folk medicine as the treatment of many diseases. The aim of the present investigation is to evaluate the gastroprotective effects of ethanolic extracts ofJ. sambacleaves against acidified ethanol-induced gastric ulcers in rats. Seven groups of rats were orally pre-treated with carboxymethylcellulose (CMC) as normal group, CMC as ulcer group, 20 mg/kg of omeprazole as positive group, 62.5, 125, 250, and 500 mg/kg of extract as the experimental groups, respectively. An hour later, CMC was given orally to normal group and acidified ethanol solution was given orally to the ulcer control, positive control, and the experimental groups. The rats were sacrificed after an hour later. Acidity of gastric content, the gastric wall mucus, ulcer areas, and histology and immunohistochemistry of the gastric wall were assessed. Gastric homogenates were determined for prostaglandin E2(PGE2), superoxide dismutase (SOD), andmalondialdehyde (MDA) content. Ulcer group exhibited significantly severe mucosal injury as compared with omeprazole or extract which shows significant protection towards gastric mucosal injury the plant promotes ulcer protection as it shows significant reduction of ulcer area grossly, and histology showed marked reduction of edema and leucocytes infiltration of submucosal layer compared with ulcer group. Immunohistochemistry showed overexpression of Hsp70 protein and downexpression of Bax protein in rats pretreated with extract. Significant increased in the pH, mucus of gastric content and high levels of PGE2, SOD and reduced amount of MDA was observed.

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“…In addition, the antioxidant effect of cattail rhizome flour was confirmed by an in vitro lipid peroxidation assay. This activity was lower than the effects of quercetin but comparable to the standardised plant extracts of Vochysia tucanorum, Baccharis dracunculifolia, Coccoloba uvifera and Cissus cyssoides [48-51]. …”

Section: Discussionmentioning

confidence: 89%

Dietary intervention with narrow-leaved cattail rhizome flour (Typha angustifolia L.) prevents intestinal inflammation in the trinitrobenzenesulphonic acid model of rat colitis

Fruet

Seito

Rall

et al. 2012

BMC Complement Altern Med

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BackgroundInflammatory bowel disease (IBD) is a chronic inflammation of the intestinal epithelium that is driven by the intestinal immune system, oxidative stress and the loss of tolerance to the luminal microbiota. The use of dietary products containing ingredients such as fibres and carbohydrates and/or antioxidant compounds have been used as a therapeutic strategy for intestinal diseases because these products are considered effective in the modulation of the immune system and colonic microbiota. We investigated the beneficial effects of cattail rhizome flour (Typha angustifolia L.) in the trinitrobenzenesulphonic acid (TNBS) model of rat colitis. In addition, we investigated the effects of cattail rhizome flour on the intestinal anti-inflammatory activity of prednisolone, which is a reference drug that is used for treatment of human IBD.MethodsThe present study included the preparation of flour from rhizomes of cattail (Typha angustifolia L.); an evaluation of the qualitative phytochemical profile of cattail rhizomes; an evaluation of the efficacy of cattail rhizome flour in TNBS-induced rat colitis; an evaluation of the synergistic effects of cattail rhizome flour on the intestinal anti-inflammatory activity of prednisolone; and macroscopic, clinical, biochemical, histopathological and microbiological studies to assess the healing effects of cattail rhizome flour and its synergistic effects in TNBS-induced rat colitis. The data were analysed by ANOVA, Kruskal-Wallis and χ2 tests.ResultsWe tested several concentrations of cattail rhizome flour and found that dietary supplementation with 10% cattail rhizome flour showed the best effects at reducing the extension of the lesion, the colon weight ratio, adherences to adjacent organs and diarrhoea. These effects were related to inhibition of myeloperoxidase (MPO) and alkaline phosphatase (AP) activities and an attenuation of glutathione (GSH) depletion. The 10% cattail rhizome flour was as effective as prednisolone, and no synergistic effects were observed. Saponins, flavonoids and coumarins were detected in the rhizome flour. No changes were observed in the total number of lactic bacteria after dietary supplementation with cattail rhizome flour.ConclusionsDietary supplementation with 10% cattail rhizome flour and its combination with prednisolone prevent TNBS-induced colonic damage in rats, but no synergistic effects were observed. The prevention of TNBS-induced colon damage was associated with an improvement in intestinal oxidative stress, which likely resulted from the antioxidant properties of the active compounds detected in the cattail rhizome. This protective effect was not related to an improvement in lactic bacteria counts.

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Gastroprotective effect of Cissus sicyoides (Vitaceae): Involvement of microcirculation, endogenous sulfhydryls and nitric oxide

Cited by 27 publications

References 22 publications

Cissus verticillata (L.) Nicolson and C.E. Jarvis (Vitaceae): Its identification and usage in the sources from 16th to 19th century

Cissus verticillata (L.) Nicolson and C.E. Jarvis (Vitaceae): Its identification and usage in the sources from 16th to 19th century

Mechanisms of Gastroprotective Effects of Ethanolic Leaf Extract ofJasminum sambacagainst HCl/Ethanol-Induced Gastric Mucosal Injury in Rats

Dietary intervention with narrow-leaved cattail rhizome flour (Typha angustifolia L.) prevents intestinal inflammation in the trinitrobenzenesulphonic acid model of rat colitis

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