Gastroprotective and cytotoxic effect of dehydroabietic acid derivatives

Sepúlveda, Beatriz; Astudillo, Luís; Rodrı́guez, Jaime A.; Yáñez, Tania; Theoduloz, Cristina; Schmeda-Hirschmann, Guillermo

doi:10.1016/j.phrs.2005.06.004

Cited by 77 publications

(49 citation statements)

References 30 publications

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“…Many abietane acids exhibit antimicrobial activity against a wide range of microorganisms. Dehydroabietic acid derivatives have been proved to act as antiulcer agents (Sepúlveda et al 2005), and several abietane acids have shown cardiovascular effects. Furthermore, several side effects of diterpene acids, such as resin acids within pulp and paper mill effluents, are well known to be noxious to aquatic organisms (Rissanen et al 2003;Kamaya et al 2005).…”

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confidence: 99%

In vitro Bioactivity and Antimicrobial Activity of Picea abies and Larix decidua Wood and Bark Extracts

Salem

Elansary

Elkelish

et al. 2016

BioRes

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Picea abies and Larix decidua were subjected to GC/MS analyses, and antimicrobial (fungi and bacteria) assays of their stem wood and bark extracts were investigated. L. decidua bark extract exhibited the highest antifungal and antibacterial activities against the microorganisms that were screened. The microbes Penecillium ochrochloron and Aspergillus ochraceus were the most sensitive to the extracts, whereas Candida albicans was the most resistant fungus. L. decidua wood and bark did not exhibit much variation in their antibacterial activities, except against Micrococcus flavus and Pseudomonas aeruginosa. The bacterium most sensitive to the extracts was Escherichia coli, whereas the most resistant was M. flavus. 13-epimanool and α-cedrol were the main components of P. abies wood extract. The main components in its bark were abietic acid, astringin, dehydroabietic acid, and α-terpineol. The main chemical compounds in L. decidua wood extract were abietic acid, oleanolic acid, duvatrienediol, and larixol. The main chemical compounds in its bark were (-)-2,9-dihydroxyverrucosane and larixol. The study revealed that P. abies and L. decidua stem wood and bark extracts contain several compounds that have antimicrobial activities towards diverse human pathogenic, food, and agricultural microbes. These results might guide in future searches for novel natural products with chemotherapeutic uses. (El-Shatby), Alexandria University, Alexandria, Egypt; b: Molecular Biology Laboratory, Floriculture, Ornamental Horticulture and Garden Design Department, Faculty of Agriculture (El-Shatby), Alexandria University, Alexandria, Egypt; c: Department of Botany, Faculty of Science, Suez Canal University, Ismailia 41522, Egypt; d: Department of Wood Processing, Faculty of Forestry and Wood Sciences, Czech University of Life Sciences Prague, Prague, Czech Republic; e: Department of Botany and Microbiology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia; f: Department of Timber Trees Research, Sabahia Horticulture Research Station, Horticulture Research Institute, Agriculture Research Center, Alexandria, Egypt; g: Department of Environmental Sciences, University of South Africa, Florida campus, Florida 1710, South Africa; * Corresponding author: zidan_forest@yahoo.com; mohamed-salim@alexu.edu.eg Keywords: Picea abies; Larix decidua; Antifungal activity; Antibacterial activity; GC/MS Contact information: a: Department of Forestry and Wood Technology, Faculty of Agriculture INTRODUCTIONForestry residues such as tree barks and branches are important but underexplored supplies of biologically or pharmaceutically active compounds (Liimatainen et al. 2012;Si et al. 2012;Patinha et al. 2013). Tree bark, for example, provides not only a physical protective barrier for plants, but also an important chemical defense mediated through the secondary compounds they produce (Horsfall 1980;Merrill 1992;Alfredsen et al. 2008). Numerous studies recently conducted on bark extracts focus on tropical tree spec...

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confidence: 99%

In vitro Bioactivity and Antimicrobial Activity of Picea abies and Larix decidua Wood and Bark Extracts

Salem

Elansary

Elkelish

et al. 2016

BioRes

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“…[28] [29] AGS cells (human gastric cell line; American Type Culture Collection, Manassas, VA) were seeded on 96-well plates at a density of 5000 cells/well and cultured in 200 ml RPMI-1640 (GIBCO) containing 10% FBS (GIBCO) and 10 mg/ml gentamycin in a CO 2 incubator at 378 for 24 h. Then, 2 ml of test drug dissolved in DMSO was added into each well for 72 h, cell proliferation was measured by the MTT ( ¼ 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium hydrobromide) assay (Sigma-Aldrich Co., St. Louis, MO, USA) for cell viability. AGS were incubated with 0.25 mg/ ml MTT for 4 h at 378, and the reaction was terminated by the addition of 100% i-PrOH.…”

Section: Inhibitory Activity ½% ¼mentioning

confidence: 99%

Bioactive Marine Prostanoids from Octocoral Clavularia viridis

Lin

Khalil

Chiou

et al. 2008

Chemistry & Biodiversity

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Chemical investigation of the nonpolar extract of soft coral Clavularia viridis resulted in isolation of five new prostanoids, designated as claviridic acids A-E (1-5, resp.), in addition to the known clavulones I-III. Their structures were determined on the basis of spectroscopic techniques, especially HR-ESI-MS, CD, and 2D-NMR experiments. The isolated marine prostanoids exhibited potent inhibitory effect on PHA-induced proliferation of peripheral blood mononuclear cells (PBMC), as well as significant cytotoxic activity against human gastric cancer cells (AGS).

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“…The potential of abietane acids as source for bioactive compounds was reviewed by San Felician et al (1993). It has been found that pine resin acids and their derivatives have shown a broad spectrum of biological activities such as antitumor (Rao et al, 2008a, b), antimicrobial (Savluchinske et al, 1999), antiinflammatory (Fernandez et al, 2001), and gastroprotective (Sepulveda et al, 2005) effects. Rosin acids were reported to have properties of enhancing the inhibitory activity of an anticancer drug in cervical carcinoma cells, hepatocellular carcinoma cells, or breast cancer cells (Lin and Chuang, 2003).…”

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Synthesis and antitumor activities of unsymmetrically disubstituted acylthioureas fused with hydrophenanthrene structure

Rao

Song

et al. 2010

Med Chem Res

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A series of novel unsymmetrically disubstituted acylthioureas fused with hydrophenanthrene structure were synthesized from D 8 -dihydroabietic and dehydroabietic acid, respectively. Their structures were characterized by IR, 1 H-, and 13 C-NMR spectroscopy. The antitumor activities of the title compounds against SMMC7721 and A549 tumor cells were evaluated by MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) method. The results showed that three compounds (4c1, 4d1, and 4d2) exhibited highly effective activities against SMMC7721 and A549 cells, their IC 50 values are between 1.87-12.67 lM for SMMC7721 cells and 2.20-6.79 lM for A549 cells, respectively. Structure-activity relationship indicating that acylthioureas that furan group fused with D 8 -dihydroabietyl group, trihydroxymethyl fused with D 8 -dihydroabietyl and dehydroabietyl could generate enhance activities of this kind of compounds against SMMC7721 and A549 cells.

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Gastroprotective and cytotoxic effect of dehydroabietic acid derivatives

Cited by 77 publications

References 30 publications

In vitro Bioactivity and Antimicrobial Activity of Picea abies and Larix decidua Wood and Bark Extracts

In vitro Bioactivity and Antimicrobial Activity of Picea abies and Larix decidua Wood and Bark Extracts

Bioactive Marine Prostanoids from Octocoral Clavularia viridis

Synthesis and antitumor activities of unsymmetrically disubstituted acylthioureas fused with hydrophenanthrene structure

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