Gastroprotective and antioxidant effects of Eremurus spectabilis Bieb. methanol extract and its isolated component isoorientin on indomethacin induced gastric ulcers in rats

Karaoğlan, Esen Sezen; Albayrak, Abdulmecit; Kutlu, Zerrin; Bayır, Yasin

doi:10.1590/s0102-865020180070000006

Cited by 17 publications

(9 citation statements)

References 26 publications

(33 reference statements)

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“…In the naproxen-induced gastric ulcer model in rats, pretreatment with 20, 50, and 80 mg/kg anthocyanins twice daily for 3 days reduced gastric MDA levels and increased CAT and SOD activity [ 81 ]. Isoorientin, derived from Eremurus spectabilis , significantly decreased the MDA level ( p < 0.05) and increased SOD activity and the GSH level in gastric tissues at doses of 25, 50, and 100 mg/kg [ 82 ]. Flavonoids, including hesperidin [ 47 , 48 , 54 , 83 ], diosmin [ 63 ], nobiletin [ 64 ], and genistein [ 62 ], aromadendrin-4′- O -methyl-ether and kaempferide [ 84 ] from Brazilian green propolis, and biochanin A [ 85 ] from soy and red clover also showed positive effects in treating peptic ulcer by increasing activities of antioxidant enzymes in vivo.…”

Section: Anti-ulcer Mechanisms Of Flavonoidsmentioning

confidence: 99%

Preventative and Therapeutic Potential of Flavonoids in Peptic Ulcers

Zhang

Lian

et al. 2020

Molecules

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Peptic ulcer disease is a common gastrointestinal tract disorder that affects up to 20% of the population of the world. Treatment of peptic ulcer remains challenging due to the limited effectiveness and severe side effects of the currently available drugs. Hence, natural compounds, owing to their medicinal, ecological, and other safe properties, are becoming popular potential candidates in preventing and treating peptic ulcers. Flavonoids, the most abundant polyphenols in plants, exhibit gastroprotective effects against peptic ulcer both in vivo and in vitro. In this review, we summarized the anti-ulcer functions and mechanisms, and also the bioavailability, efficacy, and safety, of flavonoid monomers in the gastrointestinal tract. Flavonoids exerted cytoprotective and rehabilitative effects by not only strengthening defense factors, such as mucus and prostaglandins, but also protecting against potentially harmful factors via their antioxidative, anti-inflammatory, and antibacterial activities. Although controlled clinical studies are limited at present, flavonoids have shown a promising preventable and therapeutic potential in peptic ulcers.

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Section: Anti-ulcer Mechanisms Of Flavonoidsmentioning

confidence: 99%

Preventative and Therapeutic Potential of Flavonoids in Peptic Ulcers

Zhang

Lian

et al. 2020

Molecules

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“…Risk assessment for any substance prior to install in any biological system is an important issue In essence, checking of the inflammatory response to a substance and the effects of it on cell membrane stability are two major consequences [23,24]. Plants containing secondary metabolites, especially the polyphenols and flavonoids alkaloids having antioxidant capacity may impart anti-inflammatory effects in biological systems [25,26,27]. Generally, inflammation is a type of protective response, but at severity level, it may cause serious problems in our body, including cardiovascular and neurological diseases and disorders [28,29].…”

Section: Discussionmentioning

confidence: 99%

Untitled

2019

TAPI

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The search for new therapeutic remedies from natural sources is a continuous process. Momordica charantia under the family Cucurbitaceous is commonly known as tita korola in Bangladesh. Traditionally, it is used to treat many diseases, including diabetes and obesity, infections, cough, respiratory diseases, wounds and skin diseases, ulcer, gout and rheumatism, spasm, and cancer. This study aimed at the evalualtion of toxicity, anti-inflammatory, membrane stabilizing and thrombolytic activity of M. charantia aqueous leaf extract by applying a number of in vitro and ex vivo test systems. For this, toxicity analysis was done in Allium cepa, while anti-inflammatory, and membrane stabilizing and clotlysis capacity were tested by using egg albumin and human erythrocytes, respectively. Additionally, preliminary phytochemical analysis was also done. The results suggest that the crude aqueous crude extract of M. charantia possesses alkaloid, flavonoid, terpinoid, saponins, glycoside, tannins, and reducing sugars. The crude extract exhibited toxicity in A. cepa in a concentration and time-dependent manner. No adaptation capacity of DNA damage was seen during the exposure time (24-72 h). The extract at 0.03-0.14% (v/v) significantly (p <0.05, p <0.01, p <0.001) inhibited protein denaturation, membrane lysis and clot lysis capacity in a concentration-dependent manner. Of note, the extract exerted toxic effects at high concentrations, while protective effects against toxic and cytotoxic effects at low concentrations. M. charantia may be one of the potential sources of phytotherapeutic agents for various diseases, including oxidative stress, inflammatory diseases and cancer.

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“…3 Several plants have been reported to be effective in the treatment of peptic ulcer. Some of these plants include Hibiscus asper, 4 Eremurus spectabilis, 5 Cnidoscolus aconitifolius. 6 Serafino et al 7 reported that many plant extracts are as effective as the synthetic drugs with no or insignificant adverse effect.…”

Section: Introductionmentioning

confidence: 99%