Gastroprotective and antioxidant effects of usnic acid on indomethacin-induced gastric ulcer in rats

Odabaşoğlu, Fehmi; Çakır, Ahmet; Süleyman, Halis; Aslan, Ali; Bayır, Yasin; Halici, Mesut; Kazaz, Cavit

doi:10.1016/j.jep.2005.06.043

Cited by 253 publications

(194 citation statements)

References 38 publications

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“…It has been reported in the literature that oxidant substances that occur due to oxidative stress cause inflammatory pain (7). Odabaşoğlu et al (27) proved that the level of MPO activity increased in inflamed tissue. Additionally, inflammation has been reported to play an important role in neuropathic pain.…”

Section: Discussionmentioning

confidence: 98%

The Effect of Anakinra on Paclitaxel-Induced Peripheral Neuropathic Pain in Rats

Kuyrukluyıldız¹,

Küpeli²,

Bedir³

et al. 2017

Turk J Anaesth Reanim

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Section: Discussionmentioning

confidence: 98%

The Effect of Anakinra on Paclitaxel-Induced Peripheral Neuropathic Pain in Rats

Kuyrukluyıldız¹,

Küpeli²,

Bedir³

et al. 2017

Turk J Anaesth Reanim

Self Cite

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“…Among various factors involved in gastric mucosal lesions, oxidative damage and apoptotic cell death play significant roles in the loss of gastric mucosal integrity caused by various ulcerogens [6,25]. The generation of ROS plays a major role in the development of multiple pathologies, such as gastritis, peptic ulcerations or gastric adenocarcinoma [24,26]. Indeed, ulcers develop when oxidative damage and apoptosis predominate over the healing process by cell proliferation; in contrast, various growth factors, nitric oxide, endothelin, mitogen-activated protein kinases, and some of the oncogene such as c-myc, c-Ha-ras, and c-fos participate in ulcer improvement [7,8].…”

Section: Discussionmentioning

confidence: 99%

The Effects of Moderate Exercise on Ethanol-Induced Gastric Injuries in Rats

Rostami-Motamed

Taati

Dezfoulian

et al. 2015

Zahedan J Res Med Sci

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Background:The role of oxygen-derived free radicals in the development of pathogenesis in acute gastric lesions induced by ethanol is well known. The beneficial effects of physical training on the antioxidant defenses of numerous tissues have been proved. Objectives: The present study was designed to evaluate the effects of exercise training on ethanol-induced gastric mucosal injuries in rats. Materials and Methods:In this experimental study, 28 Sprague-Dawley male rats were divided into 4 equal groups: sedentary control, exercise control, sedentary plus ethanol and exercise plus ethanol groups. The rats were subjected to moderate treadmill exercise protocol for 30 consecutive days (one hour per day). Thereafter, ethanol-treated groups received absolute ethanol (1 mL/rat) by gavage to induce gastric ulcer. Antioxidant status and lipid peroxidation of stomach wall were measured by evaluation of glutathione peroxidase (GPx), catalase activities (CAT) and thiobarbituric acid reactive substances (TBARS) concentration, respectively. Results: The histopathological findings of this study showed that moderate exercise training significantly inhibited the ethanol-induced gastric lesions in rats. Biochemical results also showed that administration of ethanol significantly decreased GPx activity and increased TBARS when compared to the sedentary control group (P < 0.05). In contrast, the exercise plus ethanol group showed higher GPx activity and lower TBARS concentration when compared to the ethanol-treated rats (P < 0.05). The catalase activity in ethanol-treated rats tended to be decreased when compared to control group. Conclusions: It seems that the preventive effects of exercise training may be mediated through increasing GPx activity subsequently inhibition of lipid peroxidation in stomach wall of rats. BackgroundThere is extensive evidence documenting the health-promoting effects of exercise [1]. Several reports have studied the useful effects of exercise on the gastrointestinal tract such as protective role against colon cancer, diverticular disease, cholelithiasis and constipation [2,3]. Although the mechanisms underlying these effects are not understood fully, altered gastrointestinal blood flow and motor function, neuroendocrine changes and mechanical effects are probably involved [4].Ulcerative lesions of gastrointestinal tract are one of the major side effects associated with alcohol consumption [5]. Studies have shown alterations in the antioxidant status following ulceration, suggesting that reactive oxygen species (ROS) such as superoxide anion, hydrogen peroxide, and hydroxyl radical play a crucial role in the development of ethanol-induced ulceration in rats [6,7]. ROS induce oxidative damage in membrane lipids and proteins and deplete glutathione level in gastric ulcers [6]. Indeed, "on one hand, ethanol administration reduces mucus production, gastric mucosal blood flow, bicarbonate secretion, endogenous glutathione and prostaglandin levels, and on the other hand it increases the release of histamine, ...

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“…0.3mM solution of DPPH in ethanol was prepared and 1ml of this solution was added to 1ml of various concentrations of sample (10,20,40, 60, 80 and 100μg/ml) and the reference compound (5,10,15,20,25, and 30μg/ml), shaken vigorously, left to stand in the dark at room temperature for 30min and then absorbance was measured at 517nm against a blank. Reference compound used here was Quercetin.…”

Section: Dpph Free Radical Scavenging Assaymentioning

confidence: 99%

“…Ulcer index (UI) was measured by using following formula. In Vivo Antioxidant Activity of Eemg [9] Estimation of Total Protein [10] 0.1ml homogenate was made up to 1ml with distilled water and to this 5ml of alkaline solution was added, mixed well and allowed to stand for 10min. Then 0.5ml Folin's reagent was added, mixed well and incubated at room temperature for another 10min.…”

Section: Ph Of Gastric Juicementioning

confidence: 99%

Antiulcer Evaluation of Mussaenda Glabrata Leaves on Experimentally Induced Ulcer Models of Rat

Abarnadevika¹

2017

WJPR

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The anti-ulcerogenic potential and antioxidant activity of ethanolic leaf extract of Mussaenda glabrata was investigated. The potential of the ethanolic extract to serve as antioxidants were assayed by DPPH and ABTS radical scavenging activity. Histopathological sections showed significant decrease in mucosal ulceration, inflammatory mucosal changes and submucosal edema compared to ulcer control group. These findings indicate that ethanolic leaf extract of Mussaenda glabrata possesses antiulcer, antisecretory and cytoprotective activity and, hence, can be used in the traditional management of peptic ulcer disease.

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Gastroprotective and antioxidant effects of usnic acid on indomethacin-induced gastric ulcer in rats

Cited by 253 publications

References 38 publications

The Effect of Anakinra on Paclitaxel-Induced Peripheral Neuropathic Pain in Rats

The Effect of Anakinra on Paclitaxel-Induced Peripheral Neuropathic Pain in Rats

The Effects of Moderate Exercise on Ethanol-Induced Gastric Injuries in Rats

Antiulcer Evaluation of Mussaenda Glabrata Leaves on Experimentally Induced Ulcer Models of Rat

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