Gastroprotective activity of chloroform extract of<i>Muntingia calabura</i>and<i>Melastoma malabathricum</i>leaves

Zakaria, Zainul Amiruddin; Zainol, Amal Syahirah Nur; Sahmat, Adibah; Salleh, Nurul Izzah; Hizami, Azfar; Mahmood, Nur Diyana; Nasir, Nurliana; Mamat, Siti Syariah; Kamisan, Farah Hidayah; Mohtarrudin, Norhafizah; Hamid, Siti Selina Abdul; Tohid, Siti Farah Md; Teh, Lay Kek; Salleh, Mohd Zaki

doi:10.3109/13880209.2015.1085580

Cited by 21 publications

(16 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…One of the plants in Malaysia that has been used traditionally by the Malay to treat gastric ulcer is M. malabathricum and studies have demonstrated the gastroprotective potential of the aqueous [ 21 ], chloroform [ 22 ], and methanol [ 7 , 16 ] extracts of its leaves. The methanolic extract showed the ability to attenuate ethanol- and indomethacin-induced gastric ulcer in rats [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Semipurified Ethyl Acetate Partition of Methanolic Extract of Melastoma malabathricum Leaves Exerts Gastroprotective Activity Partly via Its Antioxidant‐Antisecretory‐Anti‐Inflammatory Action and Synergistic Action of Several Flavonoid‐Based Compounds

Suhaimy

Azmi

Mohtarrudin

et al. 2017

Oxidative Medicine and Cellular Longevity

Self Cite

View full text Add to dashboard Cite

Recent study has demonstrated the gastroprotective activity of crude methanolic extract of M. malabathricum leaves. The present study evaluated the gastroprotective potential of semipurified extracts (partitions): petroleum ether, ethyl acetate (EAMM), and aqueous obtained from the methanolic extract followed by the elucidation of the gastroprotective mechanisms of the most effective partition. Using the ethanol-induced gastric ulcer assay, all partitions exerted significant gastroprotection, with EAMM being the most effective partition. EAMM significantly (i) reduced the volume and acidity (free and total) while increasing the pH of gastric juice and enhanced the gastric wall mucus secretion when assessed using the pylorus ligation assay, (ii) increased the enzymatic and nonenzymatic antioxidant activity of the stomach tissue, (iii) lost its gastroprotective activity following pretreatment with N-omega-nitro-L-arginine methyl ester (L-NAME; NO blocker) or carbenoxolone (CBXN; NP-SH blocker), (iv) exerted antioxidant activity against various in vitro oxidation assays, and (v) showed moderate in vitro anti-inflammatory activity via the LOX-modulated pathway. In conclusion, EAMM exerts a remarkable NO/NP-SH-dependent gastroprotective effect that is attributed to its antisecretory and antioxidant activities, ability to stimulate the gastric mucus production and endogenous antioxidant system, and synergistic action of several gastroprotective-induced flavonoids.

show abstract

Section: Discussionmentioning

confidence: 99%

Semipurified Ethyl Acetate Partition of Methanolic Extract of Melastoma malabathricum Leaves Exerts Gastroprotective Activity Partly via Its Antioxidant‐Antisecretory‐Anti‐Inflammatory Action and Synergistic Action of Several Flavonoid‐Based Compounds

Suhaimy

Azmi

Mohtarrudin

et al. 2017

Oxidative Medicine and Cellular Longevity

Self Cite

View full text Add to dashboard Cite

show abstract

“…Gastric ulcer is one of the most prevalent chronic diseases of the gastrointestinal tract [1, 2]. The main causes of gastric mucosal damage are infection by Helicobacter pylori , the administration of steroidal and nonsteroidal anti-inflammatory drugs (NSAIDs), stress, smoking, alcohol consumption, and nutritional deficiencies [3]. Many people are exposed to these risks, so they are vulnerable toward acquiring associated diseases, such as gastritis, that may develop into gastric ulcers [4].…”

Section: Introductionmentioning

confidence: 99%

“…Typical treatments for gastric ulcers are acid suppressant drugs, such as type-2 histamine receptor antagonists and proton pump inhibitors [2], but they have some adverse effects. Long-term use of acid suppressants can lead to gynecomastia, impotence, osteoporotic bone fracture, and deficiencies of iron and magnesium, as well as vitamin B 12 hypergastrinemia after discontinuation [3, 8, 9]. Gastric ulcers frequently recur and the symptoms last for a long time [5]; therefore, there is a need for drugs that can be taken long-term with minimal side effects.…”

Section: Introductionmentioning

confidence: 99%

Gastroprotective Effects of Paeonia Extract Mixture HT074 against Experimental Gastric Ulcers in Rats

Kim

Park

Kim

et al. 2019

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Background. Paeonia extract mixture HT074 is a standardized multiherbal mixture comprising extracts from Inula britannica flowers and Paeonia lactiflora roots, which are used to treat digestive disorders in traditional Korean medicine. This study was focused on elucidating the underlying mechanisms of the gastroprotective effects of HT074 in different gastric ulcer models. Methods. Gastric lesions were induced in rats by an HCl/EtOH solution, water immersion-restraint stress (WIRS), and indomethacin. Gastric secretions were studied in pylorus-ligated rats, while mucus secretions were assessed by measuring alcian blue-binding capacity of mucus in the rat model of HCl/EtOH-induced gastric ulcer. Additionally, the involvement of nitric oxide (NO) and sulfhydryl compounds in HT074-mediated mucosal protection was elucidated using their inhibitors, i.e., NG-nitro- L-arginine methyl ester hydrochloride (L-NAME) and N-ethylmaleimide (NEM), respectively. Furthermore, the effects on indomethacin-induced cell death and prostaglandin E2 (PGE2) levels were assessed in AGS cells. Results. Oral administration of HT074 significantly decreased gastric lesions induced by HCl/EtOH, WIRS, and indomethacin. Furthermore, it significantly decreased the volume, acidity, and total acidity of gastric juice in pylorus-ligated rats and increased the alcian blue-stained gastric mucus in HCl/EtOH-induced gastric ulcer in rats. Pretreatment with NEM abolished the gastroprotective effects of HT074, while L-NAME did not. In AGS cells, HT074 significantly reduced indomethacin-induced cell death and increased the PGE2 levels. Conclusions. These findings suggest that HT074 has gastroprotective effects against various ulcerogens, including HCl/EtOH, immersion stress, and NSAIDs. These effects are attributed to the inhibition of gastric secretions and preservation of the gastric mucosal barrier by increased mucus production, which is partially mediated through endogenous sulfhydryl compounds and PGE2. Based on these findings, we propose that HT074 may be a promising therapeutic agent for gastritis and gastric ulcer.

show abstract

“…Another attempt in the same year, made by Aligita ) scavenging assay, oxygen radical absorbance capacity (ORAC) assay, total phenolic content to determine the antioxidant potential of leaves and reported that the chloroform extract of leaves contains strong antioxidant activity. To determine the gastroprotective activity of this extract, they employed ethanol-induced and pylorus ligation induced ulcer models and reported a dosedependent gastroprotection 13 . In the same year, Zakaria et al (2016) conducted another research to determine the gastroprotective mechanism of ethyl acetate fraction from the methanolic extract of Muntingia calabura leaves on experimental male Sprague Dawley rats.…”

Section: Fig 2: Uses Of Muntingia Calabura Worldwidementioning

confidence: 99%

Untitled

2020

IJPSR

View full text Add to dashboard Cite

Background: In honor of a dutch botanist, Abraham Munting, the tree was named Muntigia calabura L. The Jamaica cherry, M. calabura is a shrub or tree which is native to Jamaica, Brazil, Mexico, and North America. M. calabura is a well-known, fast-growing tree clasped with different medicinal and health benefits. Different parts of the tree are being used for various ailments in different parts of the world. Objective: To summarize updated information regarding the pharmacological activities of Muntingia calabura L. Materials and Method: Few databases like Google Scholar, Science Direct, and Pub Med were used for the literature survey. Google and Bing search also carried out using the common and scientific names of the plant as keywords. For reviewing, articles that are related to ecology and agriculture are excluded. And articles that were not in the English language were also excluded. Results: Above mentioned search engines yielded 47 articles. Among them, 17 articles which were published between 2015 and 2019 were selected for inclusion in this review. From the literature survey, we found that M. calabura contains significant pharmacological properties like antinociceptive, antiulcer, anticancer, antispasmodic, antihyperuricemic, hepatoprotective, antidiabetic activity. Conclusion: It is evident from the literature that M. calabura possesses a significant medicinal property and requires further and in-depth research. This review is therefore intended to give baseline information for future researchers.

show abstract

Gastroprotective activity of chloroform extract ofMuntingia calaburaandMelastoma malabathricumleaves

Abstract: CEMC and CEMM exert gastroprotective effects in animals with ethanol-induced gastric ulcers via antioxidant and anti-secretory effects.

Cited by 21 publications

References 45 publications

Semipurified Ethyl Acetate Partition of Methanolic Extract of Melastoma malabathricum Leaves Exerts Gastroprotective Activity Partly via Its Antioxidant‐Antisecretory‐Anti‐Inflammatory Action and Synergistic Action of Several Flavonoid‐Based Compounds

Semipurified Ethyl Acetate Partition of Methanolic Extract of Melastoma malabathricum Leaves Exerts Gastroprotective Activity Partly via Its Antioxidant‐Antisecretory‐Anti‐Inflammatory Action and Synergistic Action of Several Flavonoid‐Based Compounds

Gastroprotective Effects of Paeonia Extract Mixture HT074 against Experimental Gastric Ulcers in Rats

Untitled

Contact Info

Product

Resources

About