Gastroparesis

Tack, Jan; Carbone, Florencia; Rotondo, Alessandra

doi:10.1097/mog.0000000000000220

Cited by 50 publications

(67 citation statements)

References 49 publications

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“…In our study, only 4.5% of diabetic patients had abnormal results of gastroscopy (except for Helicobacter pylori infection). This observation is similar to the results of other studies in which dyspepsia has been found to be predominantly functional in diabetes, and long-term poor metabolic control in diabetes leads to the development of gastroparesis [8,9,11]. Osicipenko et al showed that dyspepsia affects up to 71% of patients with type 2 diabetes, and in 42%, organic changes in the digestive tract were confirmed [8].…”

Section: Discussionsupporting

confidence: 89%

Evaluation of the prevalence of glucose metabolism disorders in patients with dyspepsia

Moczulska

Knysak

Bryczkowska

et al. 2019

Clinical Diabetology

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Introduction. As estimated by IDF, by 2045 there will be about 628 million of people living with diabetes, of which 87-91% will have type 2 diabetes. Therefore, early diagnosis of diabetes is very important, and currently only 4-50% of cases are diagnosed early enough. The aim of the study was to establish whether patients with dyspepsia may potentially be a group at high risk of developing diabetes in which screening for glucose metabolism disorders would be particularly important. Material and methods. The study included 59 women (65.5%) and 31 men (34.5%), with a mean age of 36 years, hospitalized in order to perform gastroscopy due to symptoms of dyspepsia. All patients were apparently healthy, without the history of cardiovascular diseases or diabetes, and were non-smokers. The patients were subjected to laboratory tests (random blood glucose, oral glucose tolerance test [OGTT], lipid profile, C-reactive protein level), gastroscopy and a rapid urease test for detection of active Helicobacter pylori infection. Body mass index (BMI) was also calculated. Subjects with abnormal results of the oral glucose tolerance test (OGTT) were assigned to the group with glucose metabolism disorders and the remaining subjectsto the group without glucose metabolism disorders. Statistical analysis of the obtained research results was carried out using the Statistica 7.0 PL software. Results. The subjects were divided into two subgroups based on the result of the oral glucose tolerance test, adopting the principles of diagnosing carbohydrate metabolism disorders according to the Diabetes Poland. The group with glucose metabolism disorders included 33 patients (36.5%): 5 subjects (5.5%) with impaired fasting glucose, 20 patients (22%) with impaired glucose tolerance and 8 patients (9%) with diabetes. The remaining 57 (63.5%) patients had normal results of OGTT and were assigned to the group without glucose metabolism disorders. The mean BMI in the whole examined population was 26.7 kg/m 2. Patients with glucose metabolism disorders (GMD) had a significantly higher BMI (31.1 kg/m 2). The levels of total cholesterol, LDL cholesterol and TG were higher in patients with GDM; however, the difference was not statistically significant. Random blood glucose values were significantly higher in the group with GDM, but no patient had random blood glucose ≥ 200 mg/dL. The HbA 1c value was significantly higher in the GMD group. Also, the C-reactive protein (CRP) level was significantly higher in the group of patients with GMD than in the group of healthy subjects. All patients underwent gastroscopy and abnormal results were found in 41 patients (45.5% of total study population)-in 67% in the group with GMD and 33% in the group without GDM. The most frequent pathology was Helicobacter pylori infection (25.5%). This infection was more prevalent in the group with GDM (45%) than in the group without GDM (14%). In addition, gastritis, gastric cancer, gastro-esophageal reflux, hiatal hernia, and gastric polyps were found, without significant diffe...

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Section: Discussionsupporting

confidence: 89%

Evaluation of the prevalence of glucose metabolism disorders in patients with dyspepsia

Moczulska

Knysak

Bryczkowska

et al. 2019

Clinical Diabetology

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“…PGS is a disorder of the gastrointestinal tract and a common complication after abdominal surgery. Traditional medical therapy for PGS includes behavioral and dietary modification, nasogastric tube suction, and administration of prokinetic drugs . The few patients who fail to benefit from these therapies and continue to have the debilitating symptoms of PGS may only benefit from additional surgery .…”

Section: Discussionmentioning

confidence: 99%

“…Postsurgical gastroparesis syndrome (PGS) is a complex gastric motility disorder, defined as the delayed emptying of gastric solids in the absence of mechanical obstruction. Characteristic symptoms include nausea, vomiting, epigastric pain, early satiety, and anorexia . PGS is a common complication of distal gastric resection and occurs in approximately 0.4–5.0% of post‐gastrectomy patients .…”

Section: Introductionmentioning

confidence: 99%

A quantified risk‐scoring system and rating model for postsurgical gastroparesis syndrome in gastric cancer patients

Chen

Mao

Zhang

et al. 2017

Journal of Surgical Oncology

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“…Delayed gastric emptying and slowed colonic transit are the common characteristics in diabetic patients with gastrointestinal motility disorder . Although accompanied symptoms such as nausea, vomiting, early satiety, abdominal pain, and constipation greatly affect their life quality, various therapies are unsatisfactory for their few positive outcome and limitation in duration.…”

Section: Introductionmentioning

confidence: 99%

Electroacupuncture promotes the gastrointestinal motility of diabetic mice by CNP/NPR‐B‐cGMP and PDE3A‐cGMP signaling

Song

et al. 2019

Neurogastroenterology Motil

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Background Electroacupuncture (EA) can promote gastrointestinal (GI) motility of diabetic mice, but the mechanism is not clearly elucidated. Natriuretic peptides (NPs) were related to the diabetes‐induced gut dysfunction of mice, which may be associated with ICC (interstitial cells of cajal). Besides, EA could increase the ICC of diabetic mice. Our aim was to explore whether EA can promote the gut motility by CNP/NPR‐B‐cGMP and PDE3A‐cGMP signaling in diabetic mice, and the relationship between NPs and ICC. Methods Wild C57BL/6 male mice were divided into five groups: control group, diabetic mellitus (DM group), diabetic mellitus plus sham EA group (SEA), diabetic mellitus plus low‐frequency EA group (LEA), and diabetic mellitus plus high‐frequency group (HEA). Gastrointestinal motility was assessed by gastric emptying and GI transit test. Immunofluorescence staining was applied to assess the expression level of CNP, NPR‐B, and c‐Kit. Western blot, PCR, and ELISA were used to detect the level of CNP, NPR‐B, PDE2A, PDE3A, c‐Kit, mSCF, and cGMP content. The correlativity between NPR‐B and mSCF was evaluated by Pearson's correlation and linear regression analyses. Key Results (a) EA could improve the GI dysfunction of diabetic mice. (b) CNP, NPR‐B, and cGMP contents were decreased, but the level of PDE3A, c‐Kit, and mSCF was increased in the EA groups. (c) There was a negative correlation between NPR‐B and mSCF among the groups. Conclusions and Inferences Electroacupuncture promotes the GI function by CNP/NPR‐B‐cGMP and PDE3A‐cGMP signaling in diabetic mice; up‐regulated mSCF/c‐Kit signaling by EA may be mediated partially via down‐regulation of CNP/NPR‐B signaling.

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Gastroparesis

Cited by 50 publications

References 49 publications

Evaluation of the prevalence of glucose metabolism disorders in patients with dyspepsia

Evaluation of the prevalence of glucose metabolism disorders in patients with dyspepsia

A quantified risk‐scoring system and rating model for postsurgical gastroparesis syndrome in gastric cancer patients

Electroacupuncture promotes the gastrointestinal motility of diabetic mice by CNP/NPR‐B‐cGMP and PDE3A‐cGMP signaling

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