Gastrointestinal uptake of FDG after N-butylscopolamine or omeprazole treatment in the rat

Abstract

Physiological FDG uptake in the GI tract was not decreased by the administration of N-butylscopolamine. Omeprazole was effective in decreasing FDG uptake in the small intestine and colon. Omeprazole has a potential to decrease FDG uptake rate in a limited part of the GI tract.

Impact of 18-Fluorodeoxyglucose Positron Emission Tomography on the Management of Pancreatic Cancer

“…18 On the other hand, advanced cancer of the stomach or colon shows strong accumulation of FDG, but in cases of small-sized tumors, the relatively strong physiological accumulation of FDG in the stomach or intestine hinders accurate diagnosis. 19 Of course, FDG clearance through the urine prevents the visualization of kidney and bladder tumors.…”

Influence of Bowel Preparation Before 18F-FDG PET/CT on Physiologic 18F-FDG Activity in the Intestine

“…The need to differentiate between physiologic and pathologic intestinal 18 F-FDG uptake has been discussed since the very beginnings of PET, and suggestions on patient preparation (including bowel cleansing) have been made (6)(7)(8). To our knowledge, ours has been the first prospective, naturally randomized study to investigate the value of bowel preparation with a purging agent before PET/CT.…”

“…In several publications, reduction of bowel wall motion, particularly using anticholinergic muscle-relaxing drugs, was discussed to reduce 18 F-FDG activity. However, previous results with anticholinergic drugs were rather controversial (7,8,11). Since such therapy is much more delicate than bowel preparation because of possible interaction with other drugs, a combination of both (laxative plus anticholinergic drug) did not seem useful.…”

“…Many patients will be referred for colonoscopy, which generates additional costs and causes discomfort to the patients (3,4). In the literature, recommendations have been made in order to reduce physiologic uptake of 18 F-FDG in the intestine or to improve the ability to evaluate intestinal structures (5)(6)(7)(8). However, no published study has proven that bowel preparation before PET/CT is beneficial.…”

Gastric Distension by Ingesting Food Is Useful in the Evaluation of Primary Gastric Cancer by FDG PET

“…16 For this reason, some researchers have tried to use pharmaceutical intervention to reduce FDG uptake of the stomach wall. 17,18 However, the potential effect of these drugs on uptake of FDG by the stomach and other part of the body is still not well defined.…”