Gastrointestinal synthetic epithelial linings

Li, Junwei; Wang, Thomas J.; Kirtane, Ameya R.; Shi, Yulei; Jones, Alexis M.; Moussa, Zaina L.; Lopes, Aaron; Collins, Joy; Tamang, Siddartha; Hess, Kaitlyn; Shakur, Rameen; Karandikar, Paramesh; Lee, Jung Seung; Huang, Hen Wei; Hayward, Alison

doi:10.1126/scitranslmed.abc0441

Cited by 44 publications

(44 citation statements)

References 65 publications

(90 reference statements)

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“…To overcome these obstacles, approaches such as chemical modifications and nano/microcarriers, gastrointestinal injectors are developed. [8][9][10][11][12] Despite the advancements, the viscous digestive juices may hinder effective diffusion of the modified drugs and drug carriers, and the large-sized gastrointestinal injectors may block the digestive tract. The presented microneedle robots can well solve these issues.…”

Section: Discussionmentioning

confidence: 99%

“…[ 1–5 ] Whereas, due to the complex physiological environments of gastrointestinal tracts, such as the abundant digestive enzymes, the spatio‐temporal varying pH values, and the mucosal barriers, many drugs are easily inactivated and have low absorption rates, especially macromolecules like proteins. [ 6,7 ] Thus, special chemical modifications and nanocarriers are introduced to oral drug delivery systems to overcome the biological barriers, [ 8–10 ] and physical devices based on mechanical forces are developed to realize gastrointestinal injections. [ 11,12 ] Despite the progress, it remains controversial whether these modified drugs and drug carriers can effectively diffuse through viscous digestive juices to the action sites.…”

Section: Introductionmentioning

confidence: 99%

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Magneto‐Responsive Microneedle Robots for Intestinal Macromolecule Delivery

et al. 2021

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The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/adma.202104932.Oral administration is the most convenient and commonly used approach for drug delivery, while it is still a challenge to overcome the complicated gastrointestinal barriers and realize efficient macromolecular drug absorption. Here, novel magneto-responsive microneedle robots are presented for efficient oral delivery of versatile macromolecules. These microneedle robots with three components of the magnetic substrate, the separable connection, and tips are generated by a Lego-brick-stacking-inspired multistage 3D fabrication strategy. With the assistance of commercial enteric capsule encapsulation, they can be taken orally and be released when entering the small intestine. Benefitting from their polarized magnetic substrate, the tips of the microneedle robots can orient to the small intestinal wall, overcome the barriers, insert into the tissue, and deliver encapsulated actives under specific magnetic fields. Besides, after the separable connection degrades, the tips can be left inside the tissue for continuous actives release, and the magnetic substrate can be excreted safely. Based on these features, the practical values of the microneedle robots are demonstrated by using them to orally deliver insulin and efficiently regulate the blood glucose of pigs. It is believed that the proposed microneedle robots can orally deliver diverse macromolecules and thus open a new chapter for oral administration.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Magneto‐Responsive Microneedle Robots for Intestinal Macromolecule Delivery

et al. 2021

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“…This is because the reactivity of the chemical residues in the PDA structure toward nucleophilic amines and thiols yields a superior capacity for immobilizing and conjugating a variety of molecules through Michael addition and Schiff base formations (Yang et al, 2014 ). DNA, drugs, cells, minerals, peptides, and proteins have been functionalized on PDA-modified substrates for diverse TE applications (Ryu et al, 2010 ; Tsai et al, 2014 ; Cheng et al, 2019 ; Li et al, 2020 ; Rühs et al, 2020 ). It has been reported that PDA can promote cell adhesion to various substrates (Ku and Park, 2010 ).…”

Section: Scaffold Main Characteristicsmentioning

confidence: 99%

Design Challenges in Polymeric Scaffolds for Tissue Engineering

Molina

Malollari

Komvopoulos

2021

Front. Bioeng. Biotechnol.

132

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Numerous surgical procedures are daily performed worldwide to replace and repair damaged tissue. Tissue engineering is the field devoted to the regeneration of damaged tissue through the incorporation of cells in biocompatible and biodegradable porous constructs, known as scaffolds. The scaffolds act as host biomaterials of the incubating cells, guiding their attachment, growth, differentiation, proliferation, phenotype, and migration for the development of new tissue. Furthermore, cellular behavior and fate are bound to the biodegradation of the scaffold during tissue generation. This article provides a critical appraisal of how key biomaterial scaffold parameters, such as structure architecture, biochemistry, mechanical behavior, and biodegradability, impart the needed morphological, structural, and biochemical cues for eliciting cell behavior in various tissue engineering applications. Particular emphasis is given on specific scaffold attributes pertaining to skin and brain tissue generation, where further progress is needed (skin) or the research is at a relatively primitive stage (brain), and the enumeration of some of the most important challenges regarding scaffold constructs for tissue engineering.

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“…In this context, immense efforts have been dedicated to expedite the process of PDA to nanoparticle formation equilibrium, substrate coating, or matrix crosslinking. These steps are thus critical performance indicators in this field [31–36] . Somewhat surprisingly, a counterintuitive method that retards the polymerization of dopamine into PDA rather than accelerates it is rarely investigated.…”

Section: Figurementioning

confidence: 99%

Versatile Polymer Nanocapsules via Redox Competition

Jokerst

Zhou

et al. 2021

Angewandte Chemie

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Polymer nanocapsules have demonstrated significant value in materials science and biomedical technology, but require complicated and time‐consuming synthetic steps. We report here the facile synthesis of monodisperse polymer nanocapsules via a redox‐mediated kinetic strategy from two simple molecules: dopamine and benzene‐1,4‐dithiol (BDT). Specifically, BDT forms core templates and modulates the oxidation kinetics of dopamine into polydopamine (PDA) shells. These uniform nanoparticles can be tuned between ≈70 and 200 nm because the core diameter directly depends on BDT while the shell thickness depends on dopamine. The supramolecular core can then rapidly disassemble in organic solvents to produce PDA nanocapsules. Such nanocapsules exhibit enhanced physicochemical performance (e.g., loading capacity, photothermal transduction, and anti‐oxidation) versus their solid counterparts. Particularly, this method enables a straightforward encapsulation of functional nanoparticles providing opportunities for designing complex nanostructures such as yolk–shell nanoparticles.

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Gastrointestinal synthetic epithelial linings

Cited by 44 publications

References 65 publications

Magneto‐Responsive Microneedle Robots for Intestinal Macromolecule Delivery

Magneto‐Responsive Microneedle Robots for Intestinal Macromolecule Delivery

Design Challenges in Polymeric Scaffolds for Tissue Engineering

Versatile Polymer Nanocapsules via Redox Competition

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