Gastrointestinal symptoms involvement in hospitalised COVID-19 patients in Liverpool, UK: a descriptive cross-sectional, single-centre study

Graham, Gemma; Taegtmeyer, Miriam; Lewis, J. M.; Subramanian, Sreedhar

doi:10.7861/clinmed.21-2-s23

Cited by 3 publications

(2 citation statements)

References 2 publications

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“…Elshazli et al also identified gastrointestinal symptoms in 20% of 25,252 patients in 2020, with anorexia, dysgeusia, diarrhoea, nausea and haematemesis being the most common [ 5 ]. In Liverpool, UK, gastrointestinal symptoms were observed in a third of hospitalised COVID-19 patients [ 6 ]. Research investigating gastrointestinal symptoms as a component of post-COVID syndrome, however, is less substantial.…”

Section: Introductionmentioning

confidence: 99%

A Systematic Review of the Prevalence of Persistent Gastrointestinal Symptoms and Incidence of New Gastrointestinal Illness after Acute SARS-CoV-2 Infection

Hawkings

Vaselli

Charalampopoulos

et al. 2023

Viruses

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It is known that SARS-CoV-2 infection can result in gastrointestinal symptoms. For some, these symptoms may persist beyond acute infection, in what is known as ‘post-COVID syndrome’. We conducted a systematic review to examine the prevalence of persistent gastrointestinal symptoms and the incidence of new gastrointestinal illnesses following acute SARS-CoV-2 infection. We searched the scientific literature using MedLine, SCOPUS, Europe PubMed Central and medRxiv from December 2019 to July 2023. Two reviewers independently identified 45 eligible articles, which followed participants for various gastrointestinal outcomes after acute SARS-CoV-2 infection. The study quality was assessed using the Joanna Briggs Institute Critical Appraisal Tools. The weighted pooled prevalence for persistent gastrointestinal symptoms of any nature and duration was 10.8% compared with 4.9% in healthy controls. For seven studies at low risk of methodological bias, the symptom prevalence ranged from 0.2% to 24.1%, with a median follow-up time of 18 weeks. We also identified a higher risk for future illnesses such as irritable bowel syndrome, dyspepsia, hepatic and biliary disease, liver disease and autoimmune-mediated illnesses such as inflammatory bowel disease and coeliac disease in historically SARS-CoV-2-exposed individuals. Our review has shown that, from a limited pool of mostly low-quality studies, previous SARS-CoV-2 exposure may be associated with ongoing gastrointestinal symptoms and the development of functional gastrointestinal illness. Furthermore, we show the need for high-quality research to better understand the SARS-CoV-2 association with gastrointestinal illness, particularly as population exposure to enteric infections returns to pre-COVID-19-restriction levels.

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Section: Introductionmentioning

confidence: 99%

A Systematic Review of the Prevalence of Persistent Gastrointestinal Symptoms and Incidence of New Gastrointestinal Illness after Acute SARS-CoV-2 Infection

Hawkings

Vaselli

Charalampopoulos

et al. 2023

Viruses

View full text Add to dashboard Cite

show abstract

“…Elshazli et al also identified gastrointestinal symptoms in 20% of 25,252 patients, with anorexia, dysgeusia, diarrhoea, nausea and haematemesis being most common 5 . In Liverpool, UK, gastrointestinal symptoms were observed in a third of hospitalised COVID-19 patients 6 . Research investigating gastrointestinal symptoms as a component of post-COVID syndrome, however, is less substantial.…”

Section: Introductionmentioning

confidence: 99%

A systematic review of the prevalence of persistent gastrointestinal symptoms and incidence of new gastrointestinal illness after acute SARS-CoV-2 infection

Hawkings

Vaselli

Charalampopoulos

et al. 2023

Preprint

View full text Add to dashboard Cite

It is known that SARS-CoV-2 infection can result in gastrointestinal symptoms. For some, these symptoms may persist beyond acute infection, in what is known as post-COVID syndrome. We conducted a systematic review to examine the prevalence of persistent gastrointestinal symptoms and the incidence of new gastrointestinal illness following acute SARS-CoV-2 infection. We searched scientific literature using MedLine, SCOPUS, Embase, Europe PubMed Central, medRxiv and Google Scholar from December 2019 to October 2022. Two reviewers independently identified 28 eligible articles which followed participants for various gastrointestinal outcomes after acute SARS-CoV-2 infection. Study quality was assessed using the Joanna Briggs Institute Critical Appraisal Tools. The weighted pooled prevalence for persistent gastrointestinal symptom of any nature and duration was 10.7%, compared to 4.9% in healthy controls. For six studies at a low risk of methodological bias, the symptom prevalence ranged from 0.2% to 24.1% with a median follow-up time of 13 weeks. We also identified the presence of functional gastrointestinal disorders in historically SARS-CoV-2 exposed individuals. Our review has shown that, from a limited pool of mostly low-quality studies, previous SARS-CoV-2 exposure may be associated with ongoing gastrointestinal symptoms and the development of functional gastrointestinal illness. Furthermore, we show the need for high-quality research to better understand the SARS-CoV-2 association with gastrointestinal symptoms, particularly as population exposure to enteric infections returns to pre-COVID-19-restriction levels.

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Gastrointestinal manifestations and possible mechanisms of COVID‐19 in different periods

Zhang

Chen

Qian

2021

J of Digest Diseases

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Coronavirus disease 2019 (COVID‐19), as a new infectious disease, has spread worldwide. COVID‐19 mainly impacts respiratory system, but digestive manifestations have been frequently described in COVID‐19 cases as well, even as the initial symptoms. And there have been several reports about the different gastrointestinal (GI) manifestations in mild and severe patients or in remission stages. So it is reasonable to consult that GI symptoms have distinct characteristics in different periods of COVID‐19. Therefore, this review article will try to summarize the gastrointestinal manifestations and possible mechanisms of COVID‐19 in different periods, and explain the significance of gastrointestinal manifestations in systemic inflammatory injury. This article is protected by copyright. All rights reserved.

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Gastrointestinal symptoms involvement in hospitalised COVID-19 patients in Liverpool, UK: a descriptive cross-sectional, single-centre study

Cited by 3 publications

References 2 publications

A Systematic Review of the Prevalence of Persistent Gastrointestinal Symptoms and Incidence of New Gastrointestinal Illness after Acute SARS-CoV-2 Infection

A Systematic Review of the Prevalence of Persistent Gastrointestinal Symptoms and Incidence of New Gastrointestinal Illness after Acute SARS-CoV-2 Infection

A systematic review of the prevalence of persistent gastrointestinal symptoms and incidence of new gastrointestinal illness after acute SARS-CoV-2 infection

Gastrointestinal manifestations and possible mechanisms of COVID‐19 in different periods

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