Gastrointestinal symptoms in COVID-19

Lewandowski, Konrad; Kaniewska, Magdalena; Rosołowski, Mariusz; Rydzewska, Grażyna

doi:10.5114/pg.2021.112683

Cited by 7 publications

(7 citation statements)

References 50 publications

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“…It has been demonstrated that the abundance of Coprobacillus spp., Clostridium ramosum, and Clostridium hathewayiis correlated with the severity of COVID-19, but Faecalibacterium prausnitzii showed an inverse correlation. Bacteroides dorei, Bacteroides thetaiotaomicron, Bacteroides massiliensis, and Bacteroides ovatus, with potentials to reduce angiotensin-2-converting enzyme expression in the gut, were observed to be inversely correlated with the SARS-CoV-2 burden in feces [ 30 ]. However, the heterogeneity of the gut microbiome between unvaccinated and vaccinated individuals remains obscure.…”

Section: Discussionmentioning

confidence: 99%

BBIBP-CorV Vaccination against the SARS-CoV-2 Virus Affects the Gut Microbiome

et al. 2023

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Several observational studies have confirmed that the severe acute respiratory syndrome coronavirus2 (SARS-CoV-2) might substantially affect the gastrointestinal (GI) system by replicating in human small intestine enterocytes. Yet, so far, no study has reported the effects of inactivated SARS-CoV-2 virus vaccines on gut microbiota alterations. In this study, we examined the effects of the BBIBP-CorV vaccine (ChiCTR2000032459, sponsored by the Beijing Institute of Biological Products/Sinopharm), on gut microbiota. Fecal samples were collected from individuals whoreceived two doses of intramuscular injection of BBIBP-CorV and matched unvaccinated controls. DNA extracted from fecal samples was subjected to 16S ribosomal RNA sequencing analysis. The composition and biological functions of the microbiota between vaccinated and unvaccinated individuals were compared. Compared with unvaccinated controls, vaccinated subjects exhibited significantly reduced bacterial diversity, elevated firmicutes/bacteroidetes (F/B) ratios, a tendency towards Faecalibacterium-predominant enterotypes, and altered gut microbial compositions and functional potentials. Specifically, the intestinal microbiota in vaccine recipients was enriched with Faecalibacterium and Mollicutes and with a lower abundance of Prevotella, Enterococcus, Leuconostocaceae, and Weissella. Microbial function prediction by phylogenetic investigation of communities using reconstruction of unobserved states (PICRUSt) analysis further indicated that Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways involved in carbohydrate metabolism and transcription were positively associated with vaccine inoculation, whereas capacities in neurodegenerative diseases, cardiovascular diseases, and cancers were negatively affected by vaccines. Vaccine inoculation was particularly associated with gut microbiota alterations, as was demonstrated by the improved composition and functional capacities of gut microbiota.

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Section: Discussionmentioning

confidence: 99%

BBIBP-CorV Vaccination against the SARS-CoV-2 Virus Affects the Gut Microbiome

et al. 2023

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“…Gastrointestinal symptoms, such as nausea, vomiting, loss of appetite, diarrhoea, and abdominal pain, have also been reported (Adhikari et al, 2022; Kariyawasam et al, 2021; Megyeri et al, 2021). Notably, the gastrointestinal tract contains a substantial amount of angiotensin-converting enzyme 2 (ACE-2), a receptor used by SARS-CoV-2 for cell entry (Hamming et al, 2004; Lee et al, 2020; Lewandowski et al, 2023). This allows the virus to infect human enterocytes in the gastrointestinal tract, leading to viral replication and excretion in faeces (Jones et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Wastewater monitoring of SARS-CoV-2 gene for COVID-19 epidemiological surveillance in Tucumán Argentina

D’Arpino,

Sineli,

Goroso

et al. 2023

Preprint

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Epidemiology based on the detection of pathogens in wastewater is extremely useful in providing information about a population’s health status. This study aimed to analyze and report the epidemiological dynamics of SARS-CoV-2 in the province of Tucumán, Argentina during the second and third surges of COVID-19 between April 2021 and March 2022. The study aimed to quantify SARS-CoV-2 RNA in wastewater, correlating it with clinically reported COVID-19 cases. Wastewater samples (n=72) were collected from 16 sampling points located in 3 cities of Tucumán (San Miguel de Tucumán, Yerba Buena y Banda del Río Salí). Detection of viral nucleocapsid markers (N1 gene) was carried out using one-step RT-qPCR. Viral loads were determined for each positive sample using a standard curve. A positive correlation (p<0.05) was observed between viral load (copies/mL) and the clinically confirmed COVID-19 cases reported during the sampling period in San Miguel de Tucumán. Our research findings provided a crucial insight into the dynamics of SARS-CoV-2 infection during epidemic outbreaks. The implementation of wastewater monitoring has proven to be an invaluable epidemiological tool, facilitating early detection of potential surges in COVID-19 cases, and enabling a comprehensive tracking of the pandemic. Our study underscores the significance of incorporating SARS-CoV-2 genome-based surveillance as a standard practice which will contribute to anticipating any future spikes in infections.

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“…To carry out seal drainage, opening the lumen of the hollow organs of the gastrointestinal tract is not required [ 12 ]. During opencut drainage, artificial fistulas are formed in the stomach or intestines [ 13 ]. Combined drainage methods combine, at the same time, separate techniques characteristic of closed and open methods [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

A forecasting method of postoperative intestinal paralysis and its timely resolution

Madyarov,

Kuzikeev,

Malgazhdarov

et al. 2023

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Introduction The development of intestinal paresis after surgery in patients with acute surgical conditions complicated by peritonitis is an urgent problem of abdominal surgery. Aim To study the effectiveness of the developed methods, as well as to predict the risk of intestinal paresis, and establish the possibilities of correcting this condition in patients with acute surgical pathology complicated by peritonitis. Material and methods Twenty patients were examined, in whom the temperature parameters of the mucous membrane and skin of the cheek were measured, based on which the probability of developing paresis was predicted. Results The proposed method of thermometry of the mucous membrane and cheek skin made it possible to predict a high risk of intestinal paresis in 75% of patients and low risk in 25% of patients. It was shown that 80% of patients had a complete restoration of intestinal motility on the first day after the start of treatment. In 20% of cases, a partial improvement in the motor evacuation function of the intestine was observed on the first day, and full recovery was noted on the second day after the start of therapy. Conclusions The developed methods are highly effective and suitable for predicting and correcting intestinal paresis in patients with acute surgical conditions in the postoperative period.

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Gastrointestinal symptoms in COVID-19

Cited by 7 publications

References 50 publications

BBIBP-CorV Vaccination against the SARS-CoV-2 Virus Affects the Gut Microbiome

BBIBP-CorV Vaccination against the SARS-CoV-2 Virus Affects the Gut Microbiome

Wastewater monitoring of SARS-CoV-2 gene for COVID-19 epidemiological surveillance in Tucumán Argentina

A forecasting method of postoperative intestinal paralysis and its timely resolution

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