Gastrointestinal stromal tumour-induced hypercalcaemia

Trotter, Nicola; White, Jeff

doi:10.1136/bcr-2021-243613

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2024

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Cited by 2 publications

References 30 publications

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2024

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Differential diagnosis of gastrointestinal stromal tumors versus leiomyomas by special stains

zhang,

qin,

2024

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The objective of the study was to investigate whether special stains can differentiate gastrointestinal stromal tumors (GISTs) and gastrointestinal leiomyomas (GILs). In this retrospective study, 39 cases of GISTs (diameter, 0.2–8.8 cm) and 75 cases of GILs (diameter, 0.2–4.5 cm) were recruited, all biopsy specimens were surgically resected under endoscopic ultrasound (EUS) guidance. GISTs and GILs were the most common types of mesenchymal tumors found anywhere along the gastrointestinal (GI) tract, from the esophagus to the rectum. GISTs were often associated with a higher risk of malignancy. In this study, the gender, age of onset, size and sites of the lesions, together with the number of mucosal or lamina propria lesionsa all have significant differences, nevertheless, there was no significant difference in cell morphology of GISTs and GILs tested by hematoxylin eosin (HE) stain, and all showed low echo areas by EUS examination. In this retrospective study, the GISTs and GILs had been diagnosed by immunohistochemistry (IHC), combined with clinical signs and symptoms. Subsequently, special stains including Masson's trichrome (MT) stain, Alcian blue periodic acid Schiff (AB-PAS) stain, Wright-Giemsa (W-G) stain and periodic acid Schiff (PAS) combined with diastase periodic acid Schiff (D-PAS) stains were also applied in the diagnosis, the retrospective study results showed that 92.3% GISTs were stained blue with MT stain, 97.3% GILs were stained red with MT stain (P < 0.01), almost all GISTs were PAS-negative (light purple), in contrast, all GILs were PAS-positive (rose red) (P < 0.01), all of these experiments set control using the blood vessels stained by MT and AB-PAS stains. Nevertheless, there was no significant difference between GISTs and GILs stained by W-G stain. These obvious and meaningful differential results were also confirmed in the detection of new GISTs and GILs cases using MT and AB-PAS stains. In conclusion, MT and AB-PAS stains could also identify GISTs and GILs cases, particularly, AB-PAS was more sensitive and more specific, providing a more cost-effective, simple, and high sensitivity and specificity inspection methods, which can instead of IHC analysis in the future, especially in resource-limited grass-roots testing institution.

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Gastrointestinal stromal tumour-induced hypercalcaemia

Cited by 2 publications

References 30 publications

Multiple drugs

Multiple drugs

Differential diagnosis of gastrointestinal stromal tumors versus leiomyomas by special stains

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