Gastrointestinal Stromal Tumors and Other Malignancies: a Case Series

Giuliani, Jacopo; Marzola, Marina; Indelli, Monica; Aliberti, Camillo; Sartori, Sergio; Lanza, Giovanni; Lelli, G.; Frassoldati, Antonio

doi:10.1007/s12029-012-9371-8

Cited by 13 publications

(7 citation statements)

References 15 publications

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“…In 14-20 % of the patients, this association appears mainly with solid tumors (5). Gastric GISTs are the most common ones to be involved with other tumors, and the most frequents are: gastrointestinal adenocarcinomas (stomach and colon), renal cell carcinoma, prostate, lung, female genital tract, and carcinoid tumors (6).…”

Section: Discussionmentioning

confidence: 99%

Gastrointestinal stromal tumor associated with a different malignant neoplasia

Sánchez-Garrido

Martín-Arribas²,

Prieto-Bermejo

et al. 2013

Rev. esp. enferm. dig.

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Section: Discussionmentioning

confidence: 99%

Gastrointestinal stromal tumor associated with a different malignant neoplasia

Sánchez-Garrido

Martín-Arribas²,

Prieto-Bermejo

et al. 2013

Rev. esp. enferm. dig.

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“…Different from other mesenchymal tumors, such as GI smooth muscle and nerve sheath tumors, GISTs are a spontaneous differentiation of stromal tumors (1). GISTs may appear throughout the GI tract, between the esophagus and the rectum, but are most frequently found in the stomach (50%) (2).…”

Section: Introductionmentioning

confidence: 99%

Large cystic-based gastrointestinal stromal tumor: A case report

Chen

Zhang

et al. 2014

Oncology Letters

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A 60-year-old male with increasing abdominal distension was admitted to The Fifth Affiliated Hospital of Guangzhou Medical University (Guangzhou, China). The abdominal sonogram exhibited a huge abdominal cystic-based mass with solid components in the left upper quadrant. A contrast-enhanced computed tomography scan of the abdomen revealed a large heterogeneous cystic solid tumor, but the source of the tumor could not be determined. The laparotomy demonstrated a huge cystic-based tumor with an integrated cystic wall, arising from the posterior wall of the gastric body. Multiple septa and ~3,500 ml of yellowish fluid were found in the cystic cavity. Pathological analysis showed that the tumor contained a mixture of polygonal and spindle cells. Immunohistochemical study indicated that the tumor cells were positive for CD117 and CD34. The final diagnosis was gastric gastrointestinal stromal tumor. The patient recovered well and no recurrence or metastasis was identified following a 12-month follow-up.

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“…Surgical resection is considered the treatment of choice and target chemotherapy with tyrosine kinase inhibitors is an interesting option when surgery is not feasible for medical reasons or as adjuvant therapy for high-risk tumors 4 . Almost one-third of GISTs are discovered incidentally 5 . They are known to coexist with different types of cancers either synchronously or metachronously in up to 33% of the cases 5 .…”

Section: Introductionmentioning

confidence: 99%

“…Almost one-third of GISTs are discovered incidentally 5 . They are known to coexist with different types of cancers either synchronously or metachronously in up to 33% of the cases 5 . The most frequent types of GIST-associated carcinomas are malignancies of the GI tract (47%), prostate (9%), breast (7%), hematopoietic system (7%), kidney (6%), and lung (5%) 6 .…”

Section: Introductionmentioning

confidence: 99%

Uncommon Synchronous Association between Ovarian Carcinoma and Gastrointestinal Stromal Tumor: A Case Study and Literature Review

Favero

Pfiffer

Riedlinger

et al. 2013

Tumori

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Background. The association of gastrointestinal stromal tumors (GIST) and other cancers is well known, but its synchronous occurrence with gynecological malignancies is very uncommon. Usually, the diagnosis is accidentally established. We describe a patient with GIST and concurrent ovarian cancer and discuss the clinical implications of this finding. Case report. A 64-year-old woman with a prior diagnosis of ovarian cancer developed a second recurrence after having undergone two operations and adjuvant chemotherapy. While tumor debulking was performed, a small, nonsuspicious lesion was removed from the greater curvature of the stomach. Histology revealed a GIST. Conclusion. The association of GIST and ovarian cancer is a rarity and its synchronicity may alter the oncological prognosis and therapy of the patient.

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Gastrointestinal Stromal Tumors and Other Malignancies: a Case Series

Abstract: Because of the limited number of cases, we cannot exclude an incidental relationship, but this association should be considered, especially during disease staging or surgery for other gastrointestinal cancer, when lesions in other intestinal tracts are detected. Larger studies are needed.

Cited by 13 publications

References 15 publications

Gastrointestinal stromal tumor associated with a different malignant neoplasia

Gastrointestinal stromal tumor associated with a different malignant neoplasia

Large cystic-based gastrointestinal stromal tumor: A case report

Uncommon Synchronous Association between Ovarian Carcinoma and Gastrointestinal Stromal Tumor: A Case Study and Literature Review

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