Gastrointestinal stromal tumor of the rectal mesentery

Nakayama, Tadanobu; Hirose, Hayato; Isobe, Kiyoshi; Shiraishi, Kou; Nishiumi, Takao; Mori, Syunji; Furuta, Yoshiaki; Kasahara, Masao

doi:10.1007/s005350300031

Journal of Gastroenterology

2003

DOI: 10.1007/s005350300031

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Gastrointestinal stromal tumor of the rectal mesentery

Tadanobu Nakayama

Hayato Hirose

Kiyoshi Isobe

et al.

Abstract: We report a case of gastrointestinal stromal tumor (GIST) arising from the rectal mesentery. GIST of the large intestine is a rare tumor that accounts for only 0.1% of all colorectal cancers. The patient presented to our hospital with constipation and abdominal distension. Computed tomography (CT) revealed a huge mass in the pelvic cavity, and laparotomy disclosed diffuse peritoneal dissemination from the primary tumor. Radiochemotherapy was commenced, but the patient became too ill to complete it and died of … Show more

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Cited by 14 publications

(1 citation statement)

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“…Some authors have designated GISTs developing outside the digestive tract as extra‐GISTs (EGISTs) [2]. Case reports have also documented the presence of GIST in atypical sites such as the rectovaginal septum [3], rectal mesentery [4], gallbladder [5], liver [6], urinary bladder [7] and abdominal wall [8].…”

mentioning

confidence: 99%

An omental mass: any hypothesis?

Caricato¹,

Ausania²,

Valeri³

et al. 2005

Colorectal Disease

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mentioning

confidence: 99%

An omental mass: any hypothesis?

Caricato¹,

Ausania²,

Valeri³

et al. 2005

Colorectal Disease

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A rare cause of severe dyspareunia: a case report and literature review

Akbulut

Çakabay

Sezgin

et al. 2009

Arch Gynecol Obstet

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Gastrointestinal stromal tumors (GISTs) of the rectum are rare, and their clinical manifestations are variable. We report the case of a 23-year-old woman who was referred complaining of dyspareunia during coitus. We performed digital vaginal and rectal investigations, ultrasound, colonoscopy, and computed tomography. These examinations confirmed the presence of a lesion measuring about 6 × 5 × 5 cm in size attached to the posterolateral left rectum wall. We performed a circumanal excision, then arrived at the mass between the muscles of the pelvic floor. Pathological studies indicated that the tumor was a high-grade GIST, and was clear at the surgical margins. On follow-up, a GIST was found at the gastric fundus via an endoscopic biopsy. Imatinib treatment was initiated because the patient refused a second operation. The gastric lesion disappeared 6 months after imatinib treatment. Dyspareunia disappeared 1 month after operation.

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Extra-gastrointestinal stromal tumor of the pelvic cavity: case report

et al. 2012

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Extra-gastrointestinal stromal tumors (E-GISTs) not associated with the alimentary tract in the pelvic cavity are extremely rare. We treated a 49-year-old Japanese man with such an E-GIST in the pelvic cavity who underwent an intrapelvic tumorectomy with a total prostatectomy and partial rectum resection. Gross examination of the specimen revealed an 8.1 × 5 × 4 cm white-grayish mass. Histological findings showed uniform spindle cells with scant atypia that formed interlacing bundles or whorl patterns. These neoplastic cells did not invade adjacent organs, including the gut. Immunohistochemical findings revealed that the neoplastic cells were positive for c-kit, CD34, and vimentin. Molecular analysis showed a c-kit mutation at exon 9 with duplication of Ala and Tyr. Our diagnosis was E-GIST, which belongs to the intermediate group of GIST. Following the operation, we administered imatinib mesylate for 6 months. After stopping for 5 months, it was administered again for local recurrence. We are planning our future strategy for this case including surgical resection as necessary.

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Gastrointestinal stromal tumor of the rectal mesentery

Cited by 14 publications

References 15 publications

An omental mass: any hypothesis?

An omental mass: any hypothesis?

A rare cause of severe dyspareunia: a case report and literature review

Extra-gastrointestinal stromal tumor of the pelvic cavity: case report

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