Gastrointestinal Stromal Tumor at Ampulla of Vater Presented With Upper Gastrointestinal Bleeding

Chariyawong, Phumpattra; Rakvit, Ariwan

doi:10.14309/00000434-201710001-02911

Cited by 2 publications

(4 citation statements)

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“…All the reported GISTs in the ampullary lesion were reactive with CD34. CD117 was negative in 2 cases [2,15]. Also, all of the reported DOG-1 were positive.…”

Section: Immunohistochemistry and Molecular Studiesmentioning

confidence: 86%

“…In 2 of the reported cases, simultaneous duodenal neuroendocrine tumor was also diagnosed within the duodenum [1,8]. Another patient had a past medical history of diverticulitis [2]. Family history in the case report by Leung et al [12] was positive for breast cancer, colon cancer, coronary artery disease, and stroke.…”

Section: Past Medical History and Other Medical Conditionsmentioning

confidence: 98%

“…In 8 cases, presurgical biopsies have been taken which was correctly diagnosed in 5 patients [1,2,7,12,17], and other 3 cases were either nondiagnostic (normal mucosa) or incorrectly diagnosed as carcinoma [2,16,17]. In most of the patients without perioperative histology, the clinical impression has been carcinoma of the ampulla of Vater/head of pancreas, neuroendocrine tumor, and GIST.…”

Section: Endoscopic Findingsmentioning

confidence: 99%

“…In 4 patients, duodenectomy and resection were done [7,9,12,14]. In 5 patients, sleeve duodenectomy was the procedure [2,21]. Two patients developed liver metastasis, and liver transplantation and Whipple were the procedures to resect the tumor and the metastasis [11,13].…”

Section: Treatmentmentioning

confidence: 99%

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Gastrointestinal Stromal Tumor of the Ampulla of Vater: A Narrative Review

Geramizadeh

Shojazadeh

2021

Gastrointest Tumors

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Background: Gastrointestinal stromal tumor (GIST) of the ampulla of Vater is a rare occurrence. To the best of our knowledge, there has been no published review on this rare tumor in the English literature so far. Summary: In this review, we will discuss all the reported details of the published cases, including demography, clinical presentation, imaging, gross pathology and histopathology, immunohistochemical findings, treatment modalities, and outcome of cases with the diagnosis GIST from the ampulla of Vater in the last 20 years. Key Message: Twenty-five cases of GIST in the ampulla of Vater have been reported in the last 20 years in the English literature. GIST in the ampulla of Vater are usually small tumors (<5 cm) in middle-age patients. The majority of the patients present with lower GI bleeding and abdominal pain. Imaging findings are not characteristic, and most of the patients without biopsy and with no histologic diagnosis were operated with the primary impression of adenocarcinoma, neuroendocrine tumor, and GIST. Perioperative tissue biopsy has been accurate in <70% of the cases. The majority of the reported cases of GISTs in the ampulla of Vater have been low risk with spindle-cell morphology, low mitotic figures, and minimal atypia; reactive for C-KIT and DOG-1; and nonreactive for SMA, desmin, and S100. In the majority of the cases, duodenectomy with or without Whipple’s operation has been performed, and most of the cases showed good prognosis.

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“…All the reported GISTs in the ampullary lesion were reactive with CD34. CD117 was negative in 2 cases [2,15]. Also, all of the reported DOG-1 were positive.…”

Section: Immunohistochemistry and Molecular Studiesmentioning

confidence: 86%