Gastrointestinal stromal tumor: A rare cause of neonatal intestinal obstruction

Shenoy, Manoj; Singh, Sonali; Robson, Keith; Stewart, Richard J.

doi:10.1002/(sici)1096-911x(200001)34:1<70::aid-mpo17>3.0.co;2-4

Cited by 24 publications

(23 citation statements)

References 4 publications

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“…In addition to aggressive findings and signs of malignancy, such as metastases, no lymph node enlargement was observed (Figs. 2,3,7,4,6). The recurrent tumors (n=16) were characterized by irregular borders and inhomogeneous appearance and extraluminal/combined intraluminal tumor growth.…”

Section: Discussionmentioning

confidence: 99%

“…With the advent of immunohistochemistry and electron microscopy, it became apparent that GIST may have myogenic features (smooth muscle GIST) in 36%, neural attributes [gastrointestinal autonomic of tumor (GANT)] in 31%, characteristics of both muscle and nerve (mixed GIST) in 20%, or may lack differentiation (GIST not otherwise specified) in 13% of cases [3]. Eighty percent of patients with GIST are without any symptoms, and in 20% nonspecific symptoms can be seen, such as abdominal pain and tiredness, caused by gastrointestinal bleeding and anemia, and symptoms of obstruction, invagination, and perforation [4,5,6]. Enteroclysis may depict intraluminal tumor growth [26]; however, the disadvantage of barium studies is the lack of detecting extraluminal tumor growth, in contrast to US, CT, and MRI [7,8,16].…”

Section: Introductionmentioning

confidence: 99%

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Computed tomography in gastrointestinal stromal tumors

et al. 2003

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The aim of this study was to define the imaging characteristics of primary and recurrent gastrointestinal stromal tumors (GIST) in computed tomography with respect to the tumor size. Computed tomography was performed in 35 patients with histologically confirmed gastrointestinal stromal tumors and analyzed retrospectively by two experienced and independent radiologist. The following morphologic tumor characteristics of primary ( n=20) and ( n=16) recurrent tumors were evaluated according to tumor size, shape, homogeneity, density compared with liver, contrast enhancement, presence of calcifications, ulcerations, fistula or distant metastases and the anatomical relationship to the intestinal wall, and the infiltration of adjacent visceral organs. Small GIST (<5 cm) showed a sharp tumor margin with homogeneous density and structure on unenhanced and contrast-enhanced images, and were characterized by an intraluminal tumor growth. Intermediate sized GIST (>5-10 cm) demonstrated an irregular shape, inhomogeneous density on unenhanced and contrast-enhanced images, a combined intra- and extraluminal tumor growth with aggressive findings, and infiltration of adjacent organs in 9 primary diagnosed and 2 recurrent tumors. Large GIST (>10 cm), which were observed in 8 primary tumors and 11 recurrent tumors, showed an irregular margin with inhomogeneous density and aggressive findings, and were characterized by signs of malignancy such as distant and peritoneal metastases. Small recurrent tumors had a similar appearance as compared with large primary tumors. Computed tomography gives additional information with respect to the relationship of gastrointestinal stromal tumor to the gastrointestinal wall and surrounding organs, and it detects distant metastasis. Primary and recurrent GIST demonstrate characteristic CT imaging features which are related to tumor size. Aggressive findings and signs of malignancy are found in larger tumors and in recurrent disease. Computed tomography is useful in detection and characterization of primary and recurrent tumors with regard to tumor growth pattern, tumor size, and varied appearances of gastrointestinal stromal tumors, and indirectly gives hints regarding dignity and therefore prognostic outcome.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Computed tomography in gastrointestinal stromal tumors

et al. 2003

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“…11 Usually most patients with GIST are adults, but there was a case report of a neonate with GIST of the ileum. 12 In the current case, the tumor was positive for alpha-smooth muscle actin but not for CD34 or CD117, and it thereby was differentiated from GIST. In the near future, further investigation may change the current understanding of the clinicopathologic entity of infantile intestinal leiomyosarcoma, and a new classification of mesenchymal tumors of the intestine may be proposed.…”

Section: Discussionmentioning

confidence: 56%

Infantile intestinal leiomyosarcoma is prognostically favorable despite histologic aggressiveness: Case report and literature review

Yamamoto

Tsuchiya

Ishimaru

et al. 2004

Journal of Pediatric Surgery

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“…Only 25 children less than 15 years old including our case have been reported in the literature in English [3,4,[6][7][8][9][10][11][12][13][14][15][16]. Table 1 summarizes the clinical characteristics and compares GIST in adults and children.…”

Section: Discussionmentioning

confidence: 99%

Gastrointestinal stromal tumor in a child and review of the literature

et al. 2005

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Gastrointestinal stromal tumors (GIST) are c-KIT positive neoplasm that occur predominantly in adults. A 13-year-old boy who presented with massive gastrointestinal hemorrhage was subsequently diagnosed with GIST of the stomach. The tumor originated from the lesser curvature with a narrow base and no infiltration into surrounding organs. Two metastatic lesions in the liver were also found. Total excision of the gastric lesion was performed followed by adjuvant imatinib mesylate chemotherapy. He has had no signs of recurrence during 8 months of follow-up. GIST in children are rare and their behavior is notoriously difficult to predict. We report our experience and review the literature.

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Gastrointestinal stromal tumor: A rare cause of neonatal intestinal obstruction

Cited by 24 publications

References 4 publications

Computed tomography in gastrointestinal stromal tumors

Computed tomography in gastrointestinal stromal tumors

Infantile intestinal leiomyosarcoma is prognostically favorable despite histologic aggressiveness: Case report and literature review

Gastrointestinal stromal tumor in a child and review of the literature

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