Gastrointestinal permeability in food‐allergic eczematous children

Mont, G. C. L. Du; Beach, Richard; Menzies, Ian S.

doi:10.1111/j.1365-2222.1984.tb02190.x

Cited by 62 publications

(26 citation statements)

References 18 publications

(15 reference statements)

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“…In the four patients from whom specimens were obtained both before and after the milk challenge, no significant modifications were obtained in HRP permeability, irrespective of the outcome. These four children when on a cow's milk free diet (group 11) had HRP fluxes under intact and degraded form of 8.58 + 3.01 and 48.61 5 22.89 pmo1.h-' .cmW2 and the values of these fluxes after the milk challenge were 10.38 + 2.46 and 36.09 + 2 1.07 pmol . h-' .…”

Section: Resultsmentioning

confidence: 99%

Antigen Absorption by the Jejunal Epithelium of Children with Cow's Milk Allergy

Grasset²,

et al. 1988

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ABSTRACT. To establish if intestinal permeability to exogenous antigens is involved in cow's milk allergy (CMA) in infants, 33 children 1 to 24 months old (18 controls and 1 5 with CMA) were tested for intestinal permeability to the protein marker horseradish peroxidase (HRP). Jejunal biopsies were performed either during the initial period of diagnosis, at the mean (and SE) age of 3 f 1 months, and/or 1 yr later, at the age of 13 f 2 months, just before and after a milk challenge. A small fragment of the biopsy was studied for histology and the remainder was mounted in an Ussing chamber for simultaneous measurement of mucosal to serosal transport of H R P in its intact and degraded forms and electrical parameters including short-circuit current and conductance. No modification in H R P absorption was noted in control children aged from 2 months to 11 yr, indicating that gut closure probably occurred earlier in life. During the initial period of CMA, transepithelial H R P fluxes were significantly higher, about 8-fold, in children with CMA (intact H R P flux = 48.5 f 15.2, 95% confidence interval, 11.2 to 85.7 versus 5.9 + 1.2, 95% confidence interval 2.9 to 8.3, in control children) In addition, short-circuit current was increased but conductance was unchanged. After several months on a milkfree diet, H R P flux and short-circuit current returned to control values. Just after the milk challenge and independently of -the clinical issue, a slight rise in H R P permeability was observed but it was not significant and remained within control values. These results suggest that increased permeability to proteins is probably not the primary cause of CMA, and that the increase in protein endocytosis noted during the initial period of CMA seems rather to be a secondary effect of an abnormal immunological response leading to mucosal inflammation and impairment of the endocytic process. (Pediatr Res 24:197-202, 1988)

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Section: Resultsmentioning

confidence: 99%

Antigen Absorption by the Jejunal Epithelium of Children with Cow's Milk Allergy

Grasset²,

et al. 1988

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“…Many studies that have examined relatively small numbers of patients found no evidence of altered permeability [84][85][86] while several others have found abnormalities in a subgroup of patients. [87][88][89] In at least some of these patients relief of symptoms has accompanied probiotic treatment 90 and in one study probiotics not only reduced the skin disease but also decreased elevated small intestinal permeability. 91 It is unclear from this study whether the increased permeability was a cause of the atopic dermatitis or an associated area of inflammation.…”

Section: Other Diseasesmentioning

confidence: 99%

Alterations in intestinal permeability

Arrieta

2006

Gut

541

478

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“…Thus, whilst some patients have had increased lac tulose and normal mannitol absorption [42], others have had normal lactulose and low rhamnose absorption [43], The cellobiose/ mannitol test is reported as abnormal in some patients with eczema despite normal jejunal histology [28]. Andre et al [44] re ported an increased lactulose/rhamnose ratio in their 'food allergy' patients [44] when pro vocated by specific foodstuff while no such changes were found in children [45], PEG 600 absorption was normal and PEG 4000 increased in young patients with ecze ma, independently of any food allergy symp toms [46]. Other groups find normal PEG 400 and 1000 absorption in children with food allergy [42].…”

Section: Atopic Eczema and Food Allergymentioning

confidence: 99%