Gastrointestinal Neuroectodermal Tumor: a Diagnostic Dilemma

Keditsu, Keduovinuo K.; Patkar, Shraddha; Bal, Munita; Shrikhande, Shailesh V.; Goel, Mahesh

doi:10.1007/s12262-016-1499-5

Cited by 8 publications

(5 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Systemic chemotherapy can temporarily shrink the mass and prolong life but is highly dependent on the primary site and cannot cure the disease. Some medical centers recommend hepatic arterial catheterization in selected cases, which has a significant effect on the treatment of most liver diseases [2]. e functional significance of missing microRNA has been reported in several human malignancies.…”

Section: Introductionmentioning

confidence: 99%

Application Effect Analysis of Operating Room Detailed Nursing Based on Medical Big Data in Patients Undergoing Gastrointestinal Tumor Surgery

Meng

Sun

Jin

et al. 2022

Journal of Healthcare Engineering

View full text Add to dashboard Cite

With the continuous development of internet information computing, the continuous improvement of medical and health systems, and the continuous increase of medical big data, traditional operating room care also needs to be further optimized. Medical big data is a forum data set for medical industry healthcare, electronic medical record information, clinical case record information, medical financial data, remote patient monitoring data, clinical decision support data, medical insurance data set, online consulting platform, and so on. Gastrointestinal tumors are currently one of the largest malignant tumors. Compared with ordinary patients, the presence of fear, depression, irritability, and other unhealthy emotions in patients with gastrointestinal tumors will reduce the therapeutic effect. Without careful care, the use of chemotherapy and other treatments makes patients vulnerable to various side effects. This article aims to study the use of medical big data intelligent algorithms to perform detailed care for patients during gastrointestinal tumor surgery and analyze the effects of care. This paper proposes an improved DNN algorithm; the DNN algorithm is to use several weight coefficient matrices and bias vectors to perform a series of linear operations and activation operations with the input value vector, starting from the input layer, backward calculation layer by layer, until the operation reaches the output layer, and the output result is obtained. This algorithm is used to study the theory, use mathematical formulas for method calculation and model design, and use the model to carry out detailed nursing experiments in the relevant operating room. The results of the experiment show that patients who have performed detailed care have a 27.2% improvement in treatment and rehabilitation effects than those who have not, and the level of detailed care has an obvious positive relationship with the rate of condition conversion. In the end, the hospital’s detailed care quality evaluation index, which is QEI, increases by 1 point, which can increase the rate of condition conversion by 0.4.

show abstract

Section: Introductionmentioning

confidence: 99%

Application Effect Analysis of Operating Room Detailed Nursing Based on Medical Big Data in Patients Undergoing Gastrointestinal Tumor Surgery

Meng

Sun

Jin

et al. 2022

Journal of Healthcare Engineering

View full text Add to dashboard Cite

show abstract

“…Stockman et al suggests that GNET tumors “may arise from an autonomic nervous system-related primitive cell of neural crest derivation that shows a neural line of differentiation with complete absence of melanocytic features”, supporting the Antonescu et al theory of GNET arising from neuroectodermal precursor cells with lost differentiating potential [ 3 , 10 ]. Additionally, it is notable that mitotic rate and Ki-67 of reported GNET cases spanned a wide range between 1–30 (most cases around 10–12) of 10 High Power Field and 5–90% (most cases around 20%) respectively [ 1 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ]. This observation is consistent with our reported cases.…”

Section: Literature Review and Discussionmentioning

confidence: 99%

“…She remains disease free at the time that the manuscript was written, however follow-up time is unknown [ 32 ]. In the setting of distant metastasis, especially in the liver, metastectomy, sometimes in conjunction with chemotherapy, was performed in a number of reported cases which may contribute to prolonged survival in these cases [ 18 , 29 , 33 , 34 ]. To our knowledge, there is no literature to inform the role of cytoreductive surgery and possibly intraperitoneal chemotherapy (CRS/HIPEC) for GNET with peritoneal metastases.…”

Section: Literature Review and Discussionmentioning

confidence: 99%

“…Singh et al reported a 61-year-old African American patient with a resected GNET of the right colon harboring a EWSR1-CREB1 fusion that experienced a DFS of 7 years before metastatic recurrence after adjuvant platinum and etoposide chemotherapy [ 22 ]. Other adjuvant sarcoma-based systemic treatments such as doxorubicin or epirubicin and ifosfamide, doxorubicin and dacarbazine, dacarbazine and cisplatin, vincristine, doxorubine and cyclophosphamide have been used in some case reports with variable outcomes and follow up [ 1 , 14 , 15 , 18 , 25 , 40 , 41 ]. Some reports did not specify the type of adjuvant chemotherapy [ 2 , 13 , 24 , 42 , 43 ].…”

Section: Literature Review and Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A Case Series of Metastatic Malignant Gastrointestinal Neuroectodermal Tumors and Comprehensive Genomic Profiling Analysis of 20 Cases

Cortez²,

Clinton³

et al. 2022

Current Oncology

View full text Add to dashboard Cite

Malignant gastrointestinal neuroectodermal tumor (GNET) is an ultra-rare soft tissue sarcoma, therefore often misdiagnosed and has no available standard treatment. Here, we report 3 cases of metastatic GNET with variable clinical courses. Our small case series as well as extensive literature review, further support that GNET is a spectrum of diseases with variable inherent biology and prognosis. Surgical management in the setting of recurrent/metastatic disease may be appropriate for GNET with indolent nature. Response to systemic treatments including chemotherapy and targeted treatments is variable, likely related to heterogenous biology as well. Furthermore, we retrospectively identified 20 additional GNET cases from Foundation Medicine’s genomic database and expanded on their clinicopathological and genomic features. Comprehensive genomic profiling (CGP) with DNA and RNA sequencing of this cohort, in the course of clinical care, demonstrated recurrent EWSR1 chromosomal rearrangements and a sparsity of additional recurrent or driver genomic alterations. All cases had low tumor mutational burden (TMB) and were microsatellite stable.

show abstract

“…It often affects adolescents and young adults with vague clinical presentation and highly aggressive clinical behavior [ 5 , 6 ]. The imaging findings of this entity are extremely nonspecific and under-characterized [ 6 , 7 ]. Morphologically, GNET shows diffuse sheets or nests of large, epithelioid, and polygonal tumor cells with eosinophilic or clear cytoplasm and vesicular chromatin.…”

Section: Introductionmentioning

confidence: 99%

Malignant Gastrointestinal Neuroectodermal Tumor (GNET) Mimicking Small Bowel Lymphoma: A Case Report

Jia,

Yan,

Hebbard

et al. 2024

Cureus

View full text Add to dashboard Cite

A malignant gastrointestinal neuroectodermal tumor (GNET) is a rare entity, characterized as a malignant mesenchymal neoplasm occurring exclusively near the gastrointestinal tract, prone to frequent local recurrence and metastasis. Here, we report a case of a 49-year-old male presented with abdominal pain and weight loss. The patient had a remote history of thymic B-cell lymphoma. An abdominal computed tomography (CT) scan revealed a focal wall thickening of the terminal ileum with mesenteric lymphadenopathy, suggestive of lymphoma. A core needle biopsy of the mesenteric node was inconclusive. A right hemicolectomy was subsequently performed. Histologically, abundant multinucleated osteoclast-like giant cells are present. The tumor cells show diffuse strong positivity for S100 and SOX10. EWSR1-ATF1 gene fusion was identified by fluorescence in situ hybridization (FISH), consistent with a diagnosis of GNET. This case emphasizes a diagnostic challenge of a rare malignancy.

show abstract

Gastrointestinal Neuroectodermal Tumor: a Diagnostic Dilemma

Cited by 8 publications

References 5 publications

Application Effect Analysis of Operating Room Detailed Nursing Based on Medical Big Data in Patients Undergoing Gastrointestinal Tumor Surgery

Application Effect Analysis of Operating Room Detailed Nursing Based on Medical Big Data in Patients Undergoing Gastrointestinal Tumor Surgery

A Case Series of Metastatic Malignant Gastrointestinal Neuroectodermal Tumors and Comprehensive Genomic Profiling Analysis of 20 Cases

Malignant Gastrointestinal Neuroectodermal Tumor (GNET) Mimicking Small Bowel Lymphoma: A Case Report

Contact Info

Product

Resources

About