Gastrointestinal motor dysfunction in acquired selective cholinergic dysautonomia associated with infectious mononucleosis

Vassallo, Mario; Camilleri, Michael; Caron, Bolette L.; Low, Phillip A.

doi:10.1016/0016-5085(91)90609-o

Cited by 90 publications

(53 citation statements)

References 27 publications

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“…Young et al [21] reported a similar case and called it a pandysautonomia. Since 1972, another group of patients [2,5,7,9,11,[17][18][19] who suffered from a selective dysfunction of parasympathetic and sympathetic sudomotor nervous system have been reported. Because both were cholinergically innervated at the postganglionic fibers, this group was classified as having postganglionic cholinergic dysautonomia.…”

Section: Introductionmentioning

confidence: 98%

“…Approximately ten patients [2,5,7,9,11,[17][18][19] have been diagnosed with postganglionic cholinergic dysautonomia. All showed a remarkably similar clinical presentation: young patients with an acute or subacute onset of non-reacting dilated pupils, burred vision for close objects, decreased salivation and tearing, dry skin, lower variations in the heart rate, decreased gastrointestinal motility, and decreased bladder activity.…”

Section: Introductionmentioning

confidence: 99%

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A case of incomplete postganglionic cholinergic dysautonomia

Kim

Park

Jung

et al. 2003

Journal of Neurology

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Postganglionic cholinergic dysautonomia is a relatively uncommon disease that manifests as an acute and selective dysfunction of the parasympathetic and sympathetic sudomotor nervous system. Here, we present a 27-year-old woman who suffered from subacute onset of bladder paresis. The clinical and laboratory examinations revealed a selective parasympathetic dysfunction including dilated pupils and decreased tearing without an involvement of the sympathetic sudomotor system. From clinical and laboratory evidences, it is suggested that the tonic pupil and postganglionic cholinergic dysautonomia may not be a completely different disease entity but share the same pathogenesis, which is separated only by the severity or the extent of the disease. The patient was diagnosed as 'incomplete postganglionic cholinergic dysautonomia'.

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Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

A case of incomplete postganglionic cholinergic dysautonomia

Kim

Park

Jung

et al. 2003

Journal of Neurology

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“…Manometric patterns described in autonomic neuropathies, such as diabetic gastroenteropathy include a failure to devel op a normal fed response and antral hypomotility [37][38][39][40], Again, some of these pat terns have been described in other disorders such as 'idiopathic' gastroparesis and enteric neuropathies, and their specificity and sensi tivity for extrinsic denervation remains to be defined.…”

Section: Clinical Small Intestinal Manometrymentioning

confidence: 99%

Intestinal Manometry in Man: A Historical and Clinical Perspective

Quigley¹

1994

Dig Dis

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The historical background and current status of manometry of the small intestine are reviewed. The evolution of technology for the assessment of small intestinal motor activity in man is described and advances in physiology and pathophysiology highlighted. Technological advances over the past several decades have permitted the extensive study of intestinal motility in man and have led to both a greater understanding of intestinal motor physiology and an increased awareness of the breadth of intrinsic variability. Though motor patterns have been described in various disease states, the definition of the clinical utility of intestinal manometry must await further prospective studies, which should, in particular, compare manometry with other available and less invasive tests.

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“…The available data reveal that the symptoms of delayed gastric emptying are likely to exacerbate after infections with EBV, CMV, VZV [9,10]. Initially, autonomic neuropathy is asymptomatic, with time (after one year for type 2 diabetes and 2 years for type 1 diabetes, respectively) the symptoms start to develop gradually [6].…”

Section: Description Of the State Of Knowledgementioning

confidence: 99%

Diabetic autonomic neuropathy of the gastrointestinal tract – etiopathogenesis , diagnosis, treatment and complications

Kuzemko¹,

Rymarz²,

Prystupa³

et al. 2017

J Pre Clin Clin Res.

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Introduction. Late complications of diabetes mellitus are a serious challenge for physicians treating diabetic patients. Micro-and macro-angiopathic changes are of the most severe sequels. However, it should be remembered that the effects of long-term diabetes are also associated with changes in the peripheral nervous system. One of the complications most troublesome for patients is diabetic autonomic neuropathy of the gastrointestinal (GI) tract. Objective. The review article presents the pathogenesis of diabetic neuropathy of the autonomous gastrointestinal tract, and advances in the diagnosis and treatment of this disease. The study used materials in the database which demonstrate current standards of conduct, based on the principles of EBM. Brief description of the state of knowledge. Diabetic neuropathy is one of the most common complications of diabetes mellitus. According to epidemiologists, it affects 10% to even 100% of patients with long-standing disease. Damage to the nervous fibres mainly results from hyperglycaemia, which leads to the typical symptoms of dysfunction of GI tract segments. The main additional examinations include abdominal ultrasound (US) and abdominal X-ray. In cases with oesophageal disorders accompanied by dysphagia, gastroscopy is found useful for excluding possible neoplastic lesions. The gold standard for evaluation of gastric emptying is radioisotopic scintigraphy, however it is available only in some specialistic departments. Other recommended methods include: manometry, EGG, insulin tests, NMR and expiratory tests. To date, the problem has been managed symptomatically; in special cases, surgical interventions have been required. Conclusions. At present, a wide array of treatment options is available, including new forms of drugs and less radical surgical procedures carried out in numerous centres worldwide.

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Gastrointestinal motor dysfunction in acquired selective cholinergic dysautonomia associated with infectious mononucleosis

Cited by 90 publications

References 27 publications

A case of incomplete postganglionic cholinergic dysautonomia

A case of incomplete postganglionic cholinergic dysautonomia

Intestinal Manometry in Man: A Historical and Clinical Perspective

Diabetic autonomic neuropathy of the gastrointestinal tract – etiopathogenesis , diagnosis, treatment and complications

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