Gastrointestinal Motility, Part 2: Small-Bowel and Colon Transit

Maurer, Alan H.

doi:10.2967/jnumed.113.134551

Cited by 43 publications

(43 citation statements)

References 34 publications

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“…Orocecal transit times can be measured using breath tests but these include changes due to gastric empting and do not give information about the specific motor function of the small bowel but are an indirect measure of small bowel motility. Scintigraphy transit studies involving ionizing radiation do not provide information about the motor patterns seen in the small bowel. The proposed techniques (including further frequency analysis of the power spectra) will be useful to study the time scales of contractile activity and regional patterns along the gastrointestinal tract in health and disease.…”

Section: Discussionmentioning

confidence: 99%

“…information about the specific motor function of the small bowel but are an indirect measure of small bowel motility. Scintigraphy transit studies30 involving ionizing radiation do not provide information about the motor patterns seen in the small bowel. The proposed techniques (including further frequency analysis of the power spectra) will be useful to study the time scales of contractile activity and regional patterns along the gastrointestinal tract in health andF I G U R E 5 Graphs showing the repeated analysis of area under the power spectrum (AUC power spectrum ) for the normal (A-C) and high (D-F) BMI subjects measured by the 2 observers F I G U R E 6 Graph illustrating the difference in small bowel motility during fasting and immediately after feeding using the 2 different motility parameters across all the 15 subjects.…”

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confidence: 99%

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Cine MRI assessment of motility in the unprepared small bowel in the fasting and fed state: Beyond the breath‐hold

Khalaf

Nowak

Menys³

et al. 2018

Neurogastroenterology Motil

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Cine MRI assessment of motility in the unprepared small bowel in the fasting and fed state: Beyond the breath‐hold

Khalaf

Nowak

Menys³

et al. 2018

Neurogastroenterology Motil

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“…A wireless motility capsule can also be used to measure colon transit. 22 The colon transit time is measured from the time from entry of the capsule in to the cecum, determined by a sudden drop in pH, to the time the capsule passes out of the colon, determined by a sudden drop in temperature accompanied by a loss of pressure recording. In a multicenter study of constipated patients that compared the wireless motility capsule to radiopaque markers, overall agreement in classifying patients as having either slow or normal colon transit was 87%.…”

Section: Wireless Motility Capsulementioning

confidence: 99%

Methods of Evaluation of Anorectal Causes of Obstructed Defecation

Fabrizio

Alimi

Kumar

2016

Clinics in Colon and Rectal Surgery

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Obstructed defecation is a complex disorder that results in impaired propagation of stool from the rectum. It is one of the major subtypes of functional constipation and can be secondary to either functional or anatomic etiologies. Patients with obstructed defecation typically present with symptoms of abdominal discomfort, a sensation of incomplete evacuation and rectal obstruction, passage of hard stools, the need for rectal or vaginal digitation, excessive straining, and reduced stool frequency. Evaluation of obstructed defecation is multimodal, starting with a thorough history and physical examination with focus on the abdominal, perineal, and rectal examination. Additional modalities to elicit the diagnosis of obstructed defecation include proctoscopy, colonic transit time studies, anorectal manometry, a rectal balloon expulsion test, defecography, electromyography, and ultrasound. The results from these studies should be taken in the context of each patient's clinical situation, as there is no single criterion standard for the diagnosis of obstructed defecation. Surgery is typically a last resort for these patients and the majority of patients will have good symptomatic management with diet and lifestyle changes. Patients who are found to have functional mechanisms behind their obstructed defecation also benefit from pelvic floor exercises and biofeedback therapy.

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“…The studies are described in a practice guideline issued jointly by the Society of Nuclear Medicine and Molecular Imaging and the European Association of Nuclear Medicine (17). This area of research is evolving, and application of these studies in various diseases was recently described (18).…”

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confidence: 99%

Proof of Concept: Design and Initial Evaluation of a Device to Measure Gastrointestinal Transit Time

Wagner

Savir-Baruch

Halama

et al. 2017

J. Nucl. Med. Technol.

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Chronic constipation and gastrointestinal motility disorders constitute a large part of a gastroenterology practice and have a significant impact on a patient's quality of life and lifestyle. In most cases, medications are prescribed to alleviate symptoms without there being an objective measurement of response. Commonly used investigations of gastrointestinal transit times are currently limited to radiopaque markers or electronic capsules. Repeated use of these techniques is limited because of the radiation exposure and the significant cost of the devices. We present the proof of concept for a new device to measure gastrointestinal transit time using commonly available and inexpensive materials with only a small amount of radiotracer. We assembled gelatin capsules containing aGa-citrate-radiolabeled grain of rice embedded in paraffin for use as a point-source transit device. It was tested for stability in vitro and subsequently was given orally to 4 healthy volunteers and 10 patients with constipation or diarrhea. Imaging was performed at regular intervals until the device was excreted. The device remained intact and visible as a point source in all subjects until excretion. When used along with a diary of bowel movement times and dates, the device could determine the total transit time. The device could be visualized either alone or in combination with a barium small-bowel follow-through study or a gastric emptying study. The use of a point-source transit device for the determination of gastrointestinal transit time is a feasible alternative to other methods. The device is inexpensive and easy to assemble, requires only a small amount of radiotracer, and remains inert throughout the gastrointestinal tract, allowing for accurate determination of gastrointestinal transit time. Further investigation of the device is required to establish optimum imaging parameters and reference values. Measurements of gastrointestinal transit time may be useful in managing patients with dysmotility and in selecting the appropriate pharmaceutical treatment.

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Gastrointestinal Motility, Part 2: Small-Bowel and Colon Transit

Cited by 43 publications

References 34 publications

Cine MRI assessment of motility in the unprepared small bowel in the fasting and fed state: Beyond the breath‐hold

Cine MRI assessment of motility in the unprepared small bowel in the fasting and fed state: Beyond the breath‐hold

Methods of Evaluation of Anorectal Causes of Obstructed Defecation

Proof of Concept: Design and Initial Evaluation of a Device to Measure Gastrointestinal Transit Time

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