Gastrointestinal motility and absorptive disorders in patients with inflammatory bowel diseases: Prevalence, diagnosis and treatment

Abstract

Inflammatory bowel diseases (IBD), Crohn`s disease and ulcerative colitis, are chronic conditions associated with high morbidity and healthcare costs. The natural history of IBD is variable and marked by alternating periods of flare and remission. Even though the use of newer therapeutic targets has been associated with higher rates of mucosal healing, a great proportion of IBD patients remain symptomatic despite effective control of inflammation. These symptoms may include but not limited to abdominal pain, dyspepsia, diarrhea, urgency, fecal incontinence, constipation or bloating. In this setting, commonly there is an overlap with gastrointestinal (GI) motility and absorptive disorders. Early recognition of these conditions greatly improves patient care and may decrease the risk of mistreatment. Therefore, in this review we describe the prevalence, diagnosis and treatment of GI motility and absorptive disorders that commonly affect patients with IBD.

Effect of acid-reducing agents on clinical relapse in ulcerative colitis with pH-dependent-released 5-aminosalicylic acid: a multicenter retrospective study in Japan

“…Such a situation is not rare, as acid-reducing agents are usually prescribed for functional dyspepsia, which is quite common, and UC patients are no exception. 15 Our data also showed that middle-aged patients were more often affected by administration of Asacol than younger patients. We did not assess the fecal excretion and mucosal concentration with 5-ASA.…”

Butyric Acid Increases the Therapeutic Effect of EHLJ7 on Ulcerative Colitis by Inhibiting JAK2/STAT3/SOCS1 Signaling Pathway

“…Ulcerative colitis (UC) is a non-specific chronic inflammatory bowel disease with diarrhea, abdominal pain, and bloody stool as the main clinical symptoms (Cooper et al, 1993;Pohjonen et al, 2019;Nishida et al, 2019). The lesions of UC are mainly in the mucosa or submucosa of the rectum and colon (Barros et al, 2019;Saw et al, 2019). In recent years, many clinical studies have confirmed that intestinal flora imbalance is closely related to ulcerative colitis (Xavier, 2016;Walujkar et al, 2018;Khan et al, 2019).…”

“My Body Hates Me”: A Qualitative Analysis of the Experience of Functional Nausea in Adolescent Girls and Their Mothers

“…The Rome IV classification system for functional gastrointestinal disorders (FGIDs) defines functional nausea in children and adolescents as bothersome nausea (a) occurring at least twice per week for at least two months as the primary symptom experienced, (b) not typically accompanied by vomiting, (c) not usually associated with meals, (d) not better explained by another diagnosis [ 3 ]. Functional nausea is a clinical diagnosis that is made after relevant evaluation for other possible underlying organic causes, such as inflammatory bowel disease [ 4 ], gastroparesis [ 5 ], eosinophilic esophagitis [ 6 ], celiac disease [ 7 ], and gastritis [ 8 ], has been reassuring.…”