Gastrointestinal Metastasis From Primary Lung Cancer: CT Findings and Clinicopathologic Features

Kim, So Yeon; Ha, Hyun Kwon; Park, Sung Won; Kang, Jun; Kim, Kyung Won; Lee, Seung Soo; Park, Seong Ho; Kim, Ah Young

doi:10.2214/ajr.08.1907

Cited by 67 publications

(57 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, in past clinical studies, the incidence of gastrointestinal metastasis has been reported to be as low as 0.2-1.7% (5)(6)(7)(8), and in the current study, the clinical prevalence of gastrointestinal metastasis of lung cancer was ~0.33% (7/2,066). The method underlying the spread of metastasis to the intra-abdominal region is believed to involve hematogenous and lymphatic routes (12).…”

Section: Discussionmentioning

confidence: 42%

See 1 more Smart Citation

Analysis of gastrointestinal metastasis of primary lung cancer: Clinical characteristics and prognosis

Taira

Kawabata

Gabe³

et al. 2017

Oncology Letters

View full text Add to dashboard Cite

Abstract. The prevalence of gastrointestinal metastasis of lung cancer is low. The aim of the present study was to analyze the frequency and clinical characteristics of metastases to the gastrointestinal tract by retrospectively assessing the clinical records of 2,066 patients with lung cancer. A total of 7 patients (0.33%) were diagnosed with gastrointestinal metastasis, including 4 patients with adenocarcinoma, 1 patient with large cell carcinoma and 2 patients with pleomorphic carcinoma. Furthermore, 3 of the patients presented with small bowel metastases, 2 with gastric metastases, 1 with large bowel metastasis and 1 with metastasis of the appendix. The mean time between the diagnosis of the lung tumors and the identification of gastrointestinal metastasis was 13.5 months (range, 3-49 months). The mean time between the identification of the gastrointestinal metastasis and mortality was 100.6 days (range, 21-145 days). In conclusion, the prognosis of patients with recurrence in distant organs, including the gastrointestinal tract, may be worse than patients with recurrence in distant organs, excluding the gastrointestinal tract, particularly those with symptomatic gastrointestinal metastasis. Therefore, the presence of clinical gastrointestinal metastasis may be life threatening; comprehensive evaluations are required to detect and monitor gastrointestinal metastasis during follow-up.

show abstract

Section: Discussionmentioning

confidence: 42%

“…However, the clinical incidence of gastrointestinal metastasis of lung cancer has been reported to be as low as 0.2-1.7% (3)(4)(5)(6)(7)(8). By contrast, the rate of metastasis of primary lung cancer to the gastrointestinal tract in autopsy studies is higher than the clinical frequency of gastrointestinal metastasis.…”

Section: Introductionmentioning

confidence: 96%

Analysis of gastrointestinal metastasis of primary lung cancer: Clinical characteristics and prognosis

Taira

Kawabata

Gabe³

et al. 2017

Oncology Letters

View full text Add to dashboard Cite

show abstract

“…The most common malignancy responsible for perforation of GI metastases is lung cancer, which tends to involve the small bowel [6,15]. The jejunum is more commonly affected by perforation than the ileum [3].…”

Section: Perforated Gastrointestinal Metastasismentioning

confidence: 99%

“…On CT, GI metastases of lung cancer appear as an intraluminal polypoid mass or wall thickening with variable patterns of contrast enhancement; in addition, they exhibit isoattenuation with a normal-appearing wall in many cases [15]. However, certain morphological patterns of bowel metastases are thought to be related to perforation; most cases of perforation occur in the wall-thickening type, and usually accompany a small amount of free air around the pathological bowel ( Figure 7) [15].…”

Section: Perforated Gastrointestinal Metastasismentioning

confidence: 99%

Perforated tumours in the gastrointestinal tract: CT findings and clinical implications

Kim

Kim²,

Yang³

2012

BJR

View full text Add to dashboard Cite

ABSTRACT. Perforation usually requires emergency surgery and may affect the prognosis of patients with gastrointestinal tumours. Accurate pre-operative diagnosis of these conditions is important because proper management such as curative surgical treatment may be needed. The aims of this article are to illustrate CT appearances of perforated tumours of the gastrointestinal tract and to discuss their impact on clinical management.

show abstract

“…The prognosis of gastric metastases with origin in lung cancer is very poor, survival rates being estimated at 20% at 1 year and 1% at 5 years (3,4). Although gastric metastases of lung cancer were believed to be exceptionally rare, autopsy studies report an incidence ranging from 0.19 to ≥11% (5)(6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

A rare case of advanced lung cancer presenting as a symptomatic gastric tumor

et al. 2018

View full text Add to dashboard Cite

Abstract. Although gastric metastases have been estimated to occur in less than 2% of cancer patients, an increased use of upper digestive tract endoscopy allows for a higher detection of secondary gastric tumors. We describe the case of a 66-year-old male patient presenting with mild pain in the sternum and upper abdominal area. Physical examination revealed a right parietal skull tumor, with no other significant clinical changes. Upon exclusion of an acute coronary syndrome, upper digestive tract endoscopy was performed, showing the presence of an ulcerated tumor located in the gastric fundus. Histopathologic examination of the biopsy sample and immunohistochemical tests suggested a pulmonary origin of the gastric tumor. Whole body computer tomography showed the presence of tumors in the gastric fundus, left lung, liver, kidneys, bones and brain. Transbronchial biopsy of the lung tumor certified the diagnosis of non-small cell lung cancer, with the same immunohistochemical profile as the gastric tumor. Hence, it was considered the origin of the metastases. Biopsy of the skull tumor also had the identical tumor histology. Whole brain radiotherapy was performed for the brain metastases and subsequent chemotherapy was administered. Although non-specific, gastrointestinal signs and symptoms occurring in lung cancer patients should alert the clinicians as to the possibility of gastrointestinal metastases and prompt endoscopic evaluation.

show abstract

Gastrointestinal Metastasis From Primary Lung Cancer: CT Findings and Clinicopathologic Features

Cited by 67 publications

References 11 publications

Analysis of gastrointestinal metastasis of primary lung cancer: Clinical characteristics and prognosis

Analysis of gastrointestinal metastasis of primary lung cancer: Clinical characteristics and prognosis

Perforated tumours in the gastrointestinal tract: CT findings and clinical implications

A rare case of advanced lung cancer presenting as a symptomatic gastric tumor

Contact Info

Product

Resources

About