Gastrointestinal metastases from malignant melanoma

Ricaniadis, N.; Konstadoulakis, Manoussos M.; Walsh, Debra; Cp, Karakousis

doi:10.1016/s0960-7404(10)80014-3

Cited by 85 publications

(54 citation statements)

References 26 publications

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“…Prolonged 5-year survival rates have been demonstrated following complete resection of metastases in soft tissue [17,18], lungs [3,4], and gastrointestinal tract [5][6][7]. In our present study, the 5-year survival rate following recurrence of stage IV melanoma was 21% for the 40 patients who underwent a second complete metastasectomy.…”

Section: Discussionsupporting

confidence: 45%

“…Several investigators have re-examined the role of complete surgical metastasectomy for patients with American Joint Committee on Cancer (AJCC) stage IV melanoma. Recent series have demonstrated 5-year survival rates of 20-27% [3,4] following pulmonary metastasectomy and 28-41% [5][6][7] following complete resection of gastrointestinal metastases. In all of these reports, patients rendered disease-free by surgical resection fared significantly better than those undergoing incomplete surgical resection or nonoperative management.…”

Section: Introductionmentioning

confidence: 99%

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Metastasectomy for recurrent stage IV melanoma

et al. 1999

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Section: Discussionsupporting

confidence: 45%

Section: Introductionmentioning

confidence: 99%

Metastasectomy for recurrent stage IV melanoma

et al. 1999

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“…2,3 The most frequent way is extending all implants intraluminally. They settle submucosally in the GIT and cause obstruction, ulceration and occult blood loss.…”

Section: Discussionmentioning

confidence: 99%

Ileocecal Intussusception Secondary to Bowel Metastases from Cutaneous Melanoma: Case Report

Yücel¹,

Filiz²,

Kurt³

et al. 2017

TJCD

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Altmış üç yaşındaki erkek hasta karın ağrısı, kanlı dışkılama, bulantı ve kusma şikayetleri ile hastaneye müracaat etti. Yapılan muayene ve tetkiklerinde; bilgisayarlı tomografide intestinal intussusepsiyon ve karın içi lenf düğümleri saptandı. Kolonoskopik inceleme sonrası redüksiyon sağlanamadı. Laparotomide, çekuma invajine ince barsak segmentleri redükte olmaması üzerine sağ hemikolektomi ve palpasyonda ince barsakta lümen içi saptanan tümöral kitleleri içine alan 60 cm ince barsak segmenti rezeke edildi. Patolojik inceleme sonrasında kolonda 1 ve ince barsaklarda 8 toplamda 9 adet polipoid lezyon saptandı. Histolojik incelemede sitoplazmik melanin birikimi ile epiteloid ve iğsi tümör hücreleri izlendi. İmmünohistokimyasal boyamada tümör hücrelerinde S-100, HMB-45 ve melan-A pozitif olarak bulundu. Moleküler incelenmesi BRAF geni 15 Ekzonlar c.1799> a (p.v600 A) mutasyon saptanan hastanın malign melonom olarak rapor edilmesi sonrası hasta yeniden değerlendirildi ve göğüs ön duvarında deride malign melanom saptandı. Anahtar Kelimeler: İntussusepsiyon, metastaz, melanom ÖZ ABSTRACTA 63-year-old man presented to the emergency department with abdominal pain, episodes of bloody stool, nausea, and vomiting. Abdominal computed tomography showed lower intestinal intussusception and enlarged lymph nodes. Colonoscopic reduction was not possible. Exploratory laparotomy revealed a 15-cm mass comprised of the ileocecal region that had intussuscepted secondary to the small bowel. Palliative right hemicolectomy and resection of 60 cm segments of the small bowel were performed. Pathologic examination of the excised specimen revealed polypoid masses. There were 9 polyps, 1 in the ascending colon and the others in the ileum. Histopathological examination demonstrated obvious features of melanoma associated with epitheloid and spindle tumor cells and cytoplasmic melanin deposition. The tumor cells showed positivity for S-100, HMB-45 and Melan-A. Molecular examination revealed a c.1799> A (p.v600 A) mutation in exon 15 of the BRAF gene. The patient was re-examined and a nevus was found on the left anterior chest wall.

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“…Recurrence in multiple sites worsen the prognosis, as well as the period of time without recurrence shorter than one year 3 . Other papers have shown that the presence of residual disease is what provokes greater impact on these patients' survival 1,13 . However, there is a consensus in most studies that low LDH values (<200U/L) constitute an independent factor with a positive predictive value in the long-term survival 1,6,7 .In the case herein presented, the disease was visceral, the pre-operation LDH value was over 200 U/L and the initial lesion thickness was > 0.75 mm, yet, the patient has presented long-term survival and no relapse so far, contradicting the factors advocated by the literature.…”

Section: Discussionmentioning

confidence: 99%

Metastatic melanoma of the stomach

Rocha¹,

Rodrigues²,

Borges³

et al. 2008

ABCD, arq. bras. cir. dig.

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BACKGROUND: Metastatic melanoma of the stomach is a relatively rare entity with an unusual diagnosis during life. Surgery is the treatment of choice once it alleviates the symptoms in over 90% of the cases and increases the long-term survival. CASE REPORT: A 50y woman had presented a dark spot in the ungual bed of her right-hand thumb for two years, evolving into ulceration and bleeding. The biopsy diagnosed ungual malanocytic neoplasia compatible with lentiginous melanoma confirmed by immunohistochemistry, which presented positive pigmented HMB-45 cells. After an year and a half, the patient developed metastasis of the melanoma on her left thigh and extensive ulcerated lesion in the small gastric curvature, whose biopsy was compatible with metastatic melanoma of the stomach. The hemogram found discrete anemia (Hb: 11.1 and Ht: 33%) and LDH: 333 U/L. The patient underwent total gastrectomy with reconstruction in Roux-en-Y. There was a good evolution and on the 6th post-operative day, she was discharged home. At present, in the 12th month of follow up, the patient remains without complaints, with full relief of symptoms and all normal control exams. CONCLUSION: Surgical management should always be considered for the metastatic melanoma of the gastrointestinal tract, since the procedure shows low morbidity and mortality, besides providing relief of symptoms with the improvement of the quality of life and increase in the long-term survival.

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Gastrointestinal metastases from malignant melanoma

Cited by 85 publications

References 26 publications

Metastasectomy for recurrent stage IV melanoma

Metastasectomy for recurrent stage IV melanoma

Ileocecal Intussusception Secondary to Bowel Metastases from Cutaneous Melanoma: Case Report

Metastatic melanoma of the stomach

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