Gastrointestinal metabolism of phytoestrogens in lactating dairy cows fed silages with different botanical composition

Njåstad, Kari Marie; Adler, Steffen A.; Hansen-Møller, Jens; Thuen, E.; Gustavsson, Anne‐Maj; Steinshamn, Håvard

doi:10.3168/jds.2014-8208

Cited by 45 publications

(67 citation statements)

References 52 publications

(113 reference statements)

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“…Some authors have pointed out the high concentration of enterolactone in milk rather than its low uptake (Steinshamn et al, 2008;Petit et al, 2009). Njastad et al (2014) have recently reported that factors such as reconjugation and secretion into the rumen and intestinal wall as well as in cells from the udder could be limiting factors in the content of dietary isoflavones and lignans into milk. ABCG2 has been previously reported to be involved in intestinal conjugation and hepatic metabolism of isoflavones (Alvarez et al, 2010).…”

Section: Enterolactonementioning

confidence: 99%

Effect of bovine ABCG2 polymorphism Y581S SNP on secretion into milk of enterolactone, riboflavin and uric acid

Otero

Miguel

González-Lobato

et al. 2016

animal

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The ATP-binding cassette transporter G2/breast cancer resistance protein (ABCG2/BCRP) is an efflux protein involved in the bioavailability and milk secretion of endogenous and exogenous compounds, actively affecting milk composition. A limited number of physiological substrates have been identified. However, no studies have reported the specific effect of this polymorphism on the secretion into milk of compounds implicated in milk quality such as vitamins or endogenous compounds. The bovine ABCG2 Y581S polymorphism is described as a gain-of-function polymorphism that increases milk secretion and decreases plasma levels of its substrates. This work aims to study the impact of Y581S polymorphism on plasma disposition and milk secretion of compounds such as riboflavin (vitamin B 2 ), enterolactone, a microbiota-derived metabolite from the dietary lignan secoisolariciresinol and uric acid. In vitro transport of these compounds was assessed in MDCK-II cells overexpressing the bovine ABCG2 (WT-bABCG2) and its Y581S variant (Y581S-bABCG2). Plasma and milk levels were obtained from Y/Y homozygous and Y/S heterozygous cows. The results show that riboflavin was more efficiently transported in vitro by the Y581S variant, although no differences were noted in vivo. Both uric acid and enterolactone were substrates in vitro of the bovine ABCG2 variants and were actively secreted into milk with a two-fold increase in the milk/plasma ratio for Y/S with respect to Y/Y cows. The in vitro ABCG2-mediated transport of the drug mitoxantrone, as a model substrate, was inhibited by enterolactone in both variants, suggesting the possible in vivo use of this enterolignan to reduce ABCG2-mediated milk drug transfer in cows. The Y581S variant was inhibited to a lesser extent probably due to its higher transport capacity. All these findings point to a significant role of the ABCG2 Y581S polymorphism in the milk disposition of enterolactone and the endogenous molecules riboflavin and uric acid, which could affect both milk quality and functionality.

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Section: Enterolactonementioning

confidence: 99%

Effect of bovine ABCG2 polymorphism Y581S SNP on secretion into milk of enterolactone, riboflavin and uric acid

Otero

Miguel

González-Lobato

et al. 2016

animal

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“…The main metabolism of phytoestrogens occurred in the rumen and the main route of excretion was through feces and urine, with only a small part being excreted in milk. The concentration of phytoestrogens in milk can be manipulated through intake but the intermediate transfer capacity to milk appears to be limited by saturation [66].…”

Section: Characterization Of Cow Dung For Farming Systemmentioning

confidence: 99%

Review on the Potentials of Cow (Bos indicus) Based Bioenhancers in Increasing Crop Yield and Farmers Income as well as the Soil Health and Environmental Sustainability

Kumar¹,

Baliyan²,

Panwar³

et al. 2018

SAJRM

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The haphazard use of the chemical fertilizers and pesticides has detrimental effects on soil health, human health, groundwater quality and environment. This will cause more dangerous consequences for future productivity. Present status of all food grain production is in enough quantity for the population of our country but there is need to enhance the quality of food production, quality of soil, quality of ground water and quality of a healthy environment for better livelihood. These qualities can be obtained by replacing toxic chemicals through natural and organic input which is more vital for present prospect and future outlook. The “Cow” occupies the highest place of honour in Indian civilization. She is supposed to fulfil all desires of human beings, hence known as “Kamdhenu”. Owing to ignorance, after stopping of milk production, they are left uncared for forced to live extensively and eat polythene and other wastes in towns and cities. It is interesting that in Indian agricultural systems “Cow” particularly those with a hump (indigenous breed) is one of the key components, hence provision of at least one cow per hectare need to be promoted for Jaivik Krishi activities in organic farming. This review paper attempts to bring together the different use of cow based organic formulations in crop production and protection. It has been reported that organic formulation in crop production is productive and sustainable, but there is a need for strong support to it in the form of manifestation of subsidies, agricultural extension services and intensive research with solid proofs. With these efforts we can fulfil the dream of our present government; to double the income of Indian farmers.

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“…The markers Cr and Yb in reticular contents and feces were analyzed in an atomic absorption spectrophotometer (GBC SavantAA Ser. No A6990; GBC Scientific Equipment, Hampshire, IL, USA) as described by Njåstad et al (2014).…”

Section: Grass-clover Silages and Experimental Dietsmentioning

confidence: 99%

Effect of organic grass-clover silage on fiber digestion in dairy cows

Naadland

Steinshamn

Krizsan

et al. 2017

Animal

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There are differences in grass-clover proportions and chemical composition between herbage from primary growth (PG) and regrowth (RG) in grass-clover leys. Mixing silages made from PG and RG may provide a more optimal diet to dairy cows than when fed separately. We tested the hypotheses that increasing dietary proportions of grass-clover silage made from RG compared with PG would increase digestion rate of potentially degradable NDF (pdNDF), and increase ruminal accumulation of indigestible NDF (iNDF). Eight rumen cannulated Norwegian Red cows were used in two replicated 4×4 Latin squares with 21-day periods. Silages were prepared from PG and RG of an organically cultivated ley, where PG and RG silages were fed ad libitum in treatments with RG replacing PG in ratios of 0, 0.33, 0.67 and 1 on dry matter basis in addition to 8 kg concentrate. We evaluated the effect of the four diets with emphasis on rumen- and total tract fiber digestibility. Increasing RG proportions decreased silage intake by 7%. Omasal flow of pdNDF decreased, whereas iNDF flow increased with increasing RG proportions. Increasing RG proportions decreased rumen pool sizes of NDF and pdNDF, whereas pool sizes of iNDF and CP increased. Increasing RG proportions increased digestion rate of NDF, which resulted in greater total tract digestion of NDF. Pure PG diet had the highest calculated energy intake, but the improved rumen digestion of NDF by cows offered 0.33 and 0.67 of RG leveled out milk fat and protein yields among the three PG containing diets.

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Gastrointestinal metabolism of phytoestrogens in lactating dairy cows fed silages with different botanical composition

Cited by 45 publications

References 52 publications

Effect of bovine ABCG2 polymorphism Y581S SNP on secretion into milk of enterolactone, riboflavin and uric acid

Effect of bovine ABCG2 polymorphism Y581S SNP on secretion into milk of enterolactone, riboflavin and uric acid

Review on the Potentials of Cow (Bos indicus) Based Bioenhancers in Increasing Crop Yield and Farmers Income as well as the Soil Health and Environmental Sustainability

Effect of organic grass-clover silage on fiber digestion in dairy cows

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