Gastrointestinal manifestations of non-AIDS immunodeficiency

McCabe, Robert P.

doi:10.1007/s11938-002-0003-4

Cited by 20 publications

(10 citation statements)

References 40 publications

(32 reference statements)

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“…Some patients may present with GI problems as their first clinical presentation, while others develop GI complications during the course of the disease. Between 20% and 60% of individuals develop diarrheal disease, and chronic watery diarrhea is common in CVID [22,23], as we observed in 28% of our patients. Therefore immunodeficiency should be kept in mind in patients with chronic GI problems, even in the absence of recurrent respiratory infections.…”

Section: Discussionsupporting

confidence: 78%

“…We could not draw this conclusion in our eight patients with villous atrophy in comparison with other patients. Villous atrophy may be due to an autoimmune process, Giardia infection, or bacterial overgrowth [11,22]. Histologic findings of CVID enteropathy are similar to those found in patients with celiac sprue disease, but with some differences.…”

Section: Discussionmentioning

confidence: 72%

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Gastrointestinal Manifestations in Patients with Common Variable Immunodeficiency

et al. 2007

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This study focuses on endoscopic and pathologic alterations of gastrointestinal (GI) disorders of Iranian patients with common variable immunodeficiency (CVID). Nineteen of 39 CVID patients (48%) had GI complaints. The most common symptom was chronic diarrhea (28%). In endoscopic examination of small intestines, 15 patients had no abnormal finding. Duodenal biopsy revealed villous atrophy in eight and nodular lymphoid hyperplasia in three patients. There was no statistically significant difference between patients with and patients without duodenal villous atrophy regarding the presence of chronic diarrhea, anemia, and absolute CD4+T cells. In three patients, biopsies of the colon showed chronic noncrypt-destructive colitis. GI problems pose a high morbidity to CVID patients and are second only to respiratory complications. CVID patients are at increased risk of infectious and inflammatory conditions in the GI tract. Early diagnosis of these complications improves the quality of life and well-being of patients.

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 72%

Gastrointestinal Manifestations in Patients with Common Variable Immunodeficiency

et al. 2007

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“…naltrakt. Durch die fortwährende Exposition gegenüber Fremdantigenen ist der GIT in einem konstanten Status der physiologischen Entzündung (2). Die Integrität des GIT wird dabei durch mehrere Schutzmechanismen erhalten: Hierzu gehören die epitheliale Barriere mit den Schleim-sezernierenden Becherzellen sowie Paneth-Zellen, die antimikrobielle Peptide produzieren.…”

Section: Discussionunclassified

Immundefekte als Ursache von chronisch-entzündlichen Erkrankungen des Darmes

Klemann¹,

Tegtmeyer²,

Gerner³

et al. 2016

Kinder- und Jugendmedizin

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ZusammenfassungChronisch-entzündliche Darmerkrankungen (CED), mit ihren beiden prominentesten Vertretern M. Crohn und Colitis ulcerosa, zeichnen sich durch eine multifaktorielle Ätiologie mit komplexer Regulation zwischen polygenetischer Grundlage und Umwelteinflüssen aus. In den letzten Jahren wurden zahlreiche, jedoch insgesamt seltene, monogenetische Erkrankungen identifiziert, die sich mit einem CED-Phänotyp manifestieren können. Das frühe Erkennen und Anpassen der Therapien dieser heterogenen, immunologischen Erkrankungen sind von hoher Relevanz für den weiteren Verlauf der Erkrankung. In diesem Review diskutieren wir charakteristische Befunde und Umstände, die an das Vorliegen einer monogenetischen Ursache für die intestinale Inflammation denken lassen: Hinweisend können ein früher Krankheitsbeginn, ein Versagen klassischer Therapien, elterliche Konsanguinität, eine auffallende Infektanfälligkeit oder CED-untypische Begleiterkrankungen, Pathologien oder Blutwerte sein. Wir beschreiben ausgewählte Erkrankungen anhand von Fallbeispielen und zeigen auf, wie diese Erkrankungen durch die Kombination von anamnestischen Angaben und klinischen, zellulären sowie genetischen Untersuchungen diagnostiziert werden können. Hierfür schlagen wir eine gestufte, diagnostische Strategie vor, um diesen außergewöhnlichen Erkrankungen als Differenzialdiagnose einer CED nachzugehen.

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“…The next system commonly affected in PIDs is the gastrointestinal (GI) system, serving as a primary barrier to infections and considered the largest immune organ of the body. [14]…”

Section: General Conceptsmentioning

confidence: 99%

Gastrointestinal and hepatic manifestations of primary immune deficiency diseases

Al‐Muhsen

2010

Saudi J Gastroenterol

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Primary immune deficiency diseases (PIDs) are a heterogeneous group of inherited diseases characterized by variable genetic immune defects, conferring susceptibility to recurrent infections. They have a vast array of manifestations some of which involve the gastrointestinal and hepatobiliary systems. These complications can be the consequence of five different factors, namely, infection, autoimmune process, unregulated inflammation, malignancies and complications of therapeutic intervention. They may precede the PID diagnosis and, once developed, they pose high risk of morbidity. Untrained clinicians may treat these manifestations only at the level of their presentation, leaving the PIDs dangerously undiagnosed. In fact, early diagnosis of PIDs and accompanied gastrointestinal and hepatic complications clearly require appropriate treatment, and in-turn lead to an improved quality of life for the patient. To improve the awareness of gastroenterologists and related health care providers about these diseases, we have reviewed herein the complications of different PIDs focusing on gastrointestinal and hepatic manifestation.

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Gastrointestinal manifestations of non-AIDS immunodeficiency

Cited by 20 publications

References 40 publications

Gastrointestinal Manifestations in Patients with Common Variable Immunodeficiency

Gastrointestinal Manifestations in Patients with Common Variable Immunodeficiency

Immundefekte als Ursache von chronisch-entzündlichen Erkrankungen des Darmes

Gastrointestinal and hepatic manifestations of primary immune deficiency diseases

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