Gastrointestinal manifestations in Henoch‐Schönlein purpura: a review of 261 patients

Wl, Chang; Yh, Yang; Yt, Lin; Chiang, Bor‐Luen

doi:10.1111/j.1651-2227.2004.tb02623.x

Cited by 145 publications

(71 citation statements)

References 21 publications

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“…Surgical complications are rare in adults and children under the age of three. The most common surgical complication in patients with gastrointestinal involvement is invagination, and its incidence is known to be less than 1% [3,4,[22][23][24]. In our study, three patients have been operated due to invagination (0.04%).…”

Section: Discussionmentioning

confidence: 99%

Tooth fragments embedded in the lower lip following trauma

Benzer¹,

Duramaz²,

Önal³

et al. 2015

MMJ

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Objectives: Henoch-Schönlein purpura (HSP) or IgA vasculitis, is the most common form of childhood vasculitis. Mean platelet volume (MPV) is a parameter of a complete blood count that shows thrombocyte function and activation. This study evaluated the link between MPV and HSP. Patients and Methods:The data of 75 patients with a diagnosis of HSP were retrospectively evaluated. A control group was formed with 79 healthy children of similar gender and ages. results:The average ages were 6.8±3.02 years (44 males, 31 females) and 7.49±2.95 years (40 males, 39 females) for the patient and control groups respectively. Mean platelet volume was found to be significantly lower in the study group (p<0.0001). Patients' thrombocyte count were significantly higher (p<0.0001). Upon presentation 18 patients' faecal occult blood (FOB) test results were positive, and there was microscopic hematuria in 12 patients, MPV was found to be significantly lower in FOB positive patients (p=0.043).conclusion: Inflammation may affect MPV levels by increasing or decreasing. In our study, MPV measurements performed by a cheap and simple method, have been considered as a negative acute phase reactant. Decreased MPV measurements despite increased platelet count may be important in the prediction of hypercoagulopathy problems during the likely course of the disease and in close follow up for those with a predisposition. Ortalama trombosit hacmi çalışma grubunda anlamlı derecede düşük saptandı (p<0,0001). Hastaların trombosit sayısı anlamlı derecede yüksek bulundu (p<0,0001). Başvuru anında 18 hastada gizli gaite kan (GGK) testi pozitifti ve 12 hastada mikroskopik hematüri mevcuttu, GGK pozitif olan hastalarda OTH anlamlı düşük bulundu (p=0,043). sonuç: İnflamasyon, OTH düzeyini artma/azalma şeklinde etkileyebilmektedir. Çalışmamızda ucuz ve basit bir yöntem olan OTH ölçümleri negatif akut faz reaktanı olarak değerlendirilmiştir. Henoch-Schönlein purpuralı çocuklarda, artmış trombosit sayısına karşın, azalmış OTH ölçümlerinin, yatkınlığı olanlarda, hastalık seyrindeki olası hiperkoagülopati problemlerinin önceden belirlenmesinde ve yakın takipte önemli olabileceği kanısına varılmıştır.

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Section: Discussionmentioning

confidence: 99%

Tooth fragments embedded in the lower lip following trauma

Benzer¹,

Duramaz²,

Önal³

et al. 2015

MMJ

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“…It is an immune-mediated systemic vasculitis of the small vessels with an estimated incidence in children of 10.5-20.4/100,000 per year, with peak incidence between ages 2 and 6 years. [1][2][3] There is a slight male preponderance (1.2:1), with a lower incidence in black children as compared with white or Asian children. 4 The pathogenesis of HSP is not yet clearly understood, although it is known to be an immune complexmediated disease.…”

Section: Discussionmentioning

confidence: 99%

A 10-Year-Old Girl with Gastrointestinal Hemorrhage

Possenti¹,

Borali²,

Longaretti³

et al. 2015

Pediatr Ann

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A 10-year-old girl presented to our hospital with arthralgia in the lower extremities and abdominal pain. Laboratory tests were normal. Urinalysis was negative for hematuria and proteinuria. Stool for occult blood test was negative. She was given oral ibuprofen for joint pain. On the same day she also presented with fever and sore throat, so she was given oral clavulanic-amoxicillin. After a few days she presented to our hospital with advanced polyarthralgias (affecting her wrists and ankles in particular) and two episodes of vomiting.She was admitted to our unit, at which point she suddenly presented with severe abdominal pain localized in the epigastric and the lower quadrant of her abdomen, leading to hematemesis and melena. On physical examination there were discreet general conditions, the abdomen was soft, and only deep palpation evoked diffuse moderate pain. Cardiac and lung findings were normal. The girl also presented with swollen and painful wrists and ankles, and a few purpuric lesions appeared on her lower extremities and eyelid.We suspended anti-inflammatory oral therapy and began omeprazole intravenously. We positioned nasogastric and rectal tubes. Laboratory tests revealed normal values of hemoglobin and coagulation parameters, C-reactive protein of 2.1 mg/dL (normal value <.5 mg/ dL), and normal renal and liver function. Urinalysis was negative for hematuria and proteinuria. Abdominal ultrasound showed thickening of the duodenal wall (Figure 1). Esophagogastroduodenoscopy showed multiple erosions in the duodenum with hyperemic gastric mucosa, and the biopsies were compatible with leukocytoclastic vasculitis (Figure 2). Steroid therapy with intravenous methylprednisolone at 2 mg/kg was started. The patient showed progressive improvement of her general condition in the first 24 hours, and 2 days later we removed the nasogastic tube and she began a liquid diet and then began to eat lighter foods. The patient was discharged from the hospital, and her laboratory and radiological follow-up results showed complete regression of the lesions after 3 weeks of steroid therapy (Figure 3).

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“…Gastrointestinal symptoms occur in about half of children with HSP and range from mild (nausea, vomiting, abdominal pain, and transient paralytic ileus) to more significant (gastrointestinal hemorrhage, bowel ischemia and necrosis, intussusceptions, and bowel perforation) (1,2). Acute pancreatitis may be a rare complication of HSP.…”

Section: Introductionmentioning

confidence: 99%