Gastrointestinal manifestation as clinical predictor of severe <scp>COVID</scp>‐19: A retrospective experience and literature review of <scp>COVID</scp>‐19 in Association of Southeast Asian Nations (<scp>ASEAN)</scp>

Aumpan, Natsuda; Nunanan, Pongjarat; Vilaichone, Ratha-Korn

doi:10.1002/jgh3.12394

Cited by 9 publications

(9 citation statements)

References 23 publications

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“…Amongst the analysed 88 studies [ 6 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , …”

Section: Resultsunclassified

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Severity of COVID-19 in Patients with Diarrhoea: A Systematic Review and Meta-Analysis

et al. 2023

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COVID-19 patients occasionally present with diarrhoea. Our objective was to estimate the risk of developing the severe disease in COVID-19 patients with and without diarrhoea and to provide a more precise estimate of the prevalence of COVID-19-associated digestive symptoms. A total of 88 studies (n = 67,794) on patients with a COVID-19 infection published between 1 January 2020 and 20 October 2022 were included in this meta-analysis. The overall prevalence of digestive symptoms was 27% (95% confidence interval (CI): 21–34%; I2 = 99%). According to our data, the pooled prevalence of diarrhoea symptoms in the 88 studies analysed was 17% (95% CI: 14–20%; I2 = 98%). The pooled estimate of nausea or vomiting in a total of 60 studies was 12% (95% CI: 8–15%; I2 = 98%). We also analysed 23 studies with eligible individuals (n = 3800) to assess the association between the disease severity and diarrhoea. Individuals who had diarrhoea were more likely to have experienced severe COVID-19 (odds ratio: 1.71; 95% CI: 1.31–2.24; p < 0.0001; I2 = 10%). Gastrointestinal symptoms and diarrhoea are frequently presenting COVID-19 manifestations that physicians should be aware of.

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Section: Resultsunclassified

“…Emerging data indicate that diarrhoea is associated with severe COVID-19 and suggest that diarrhoea could be a reliable indicator of the onset of severe COVID-19 [ 6 ]. In other studies, diarrhoea has been linked to an increase in the severity of the COVID-19-associated pathology [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Severity of COVID-19 in Patients with Diarrhoea: A Systematic Review and Meta-Analysis

et al. 2023

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“…When using only liver enzymes (AST, ALT), gastrointestinal symptoms (diarrhea and bloating), age and presence of chronic liver disease and Diabetes mellitus the AUC is 0.799 with AST as the strongest predictor for hospitalization. Previously published studies which used mostly methods of classical statistic, have identified the presence of gastrointestinal symptoms [40] predominantly diarrhea [41], [42] and elevated liver enzymes [2] as predictors of hospitalization associated with COVID-19. In our data, we have singled out aspartate transaminase (AST) as not only the statistically significantly elevated liver enzyme in patients requiring hospitalization but using artificial intelligence with random forest algorithm AST has proved out to be the most import predictor of hospitalization.…”

Section: Discussionmentioning

confidence: 99%

A machine learning approach for identification of gastrointestinal predictors for the risk of COVID-19 related hospitalization

Liptak

Bánovčin

Rosolanka

et al. 2021

Preprint

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Background and aim: COVID-19 can be presented with various gastrointestinal symptoms. Shortly after the pandemic outbreak several machine learning algorithms have been implemented to assess new diagnostic and therapeutic methods for this disease. Aim of this study is to assess gas-trointestinal and liver related predictive factors for SARS-CoV-2 associated risk of hospitalization. Methods: Data collection was based on questionnaire from the COVID-19 outpatient test center and from the emergency department at the University hospital in combination with data from inter-nal hospital information system and from the mobile application used for telemedicine follow-up of patients. For statistical analysis SARS-CoV-2 negative patients were considered as controls to three different SARS-CoV-2 positive patient groups (divided based on severity of the disease). Results: Total of 710 patients were enrolled in the study. Presence of diarrhea and nausea was significantly higher in emergency department group than in the COVID-19 outpatient test center. Among liver enzymes only aspartate transaminase (AST) has been significantly elevated in the hospitalized group compared to patients discharged home. Based on random forest algorithm, AST has been identified as the most important predictor followed by age or diabetes mellitus. Diarrhea and bloating have also predictive importance although much lower than AST. Conclusion: SARS-CoV-2 positivity is connected with isolated AST elevation and the level is linked with the severity of the disease. Furthermore, using machine learning random forest algo-rithm, we have identified elevated AST as the most important predictor for COVID-19 related hos-pitalizations.

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“…Although more evidence is needed, it is worth considering the potential benefits of gut microbiome and immune regulators such as prebiotics and probiotics, especially in more vulnerable individuals such as people with pre-existing metabolic comorbidities or in the elderly, given their well-known predisposition for more severe COVID-19 owing to an inherently altered gut microbiome community ( 56–58 ). GI manifestations are present in SARS-CoV2–infected patients, and are positively associated with the severity of respiratory complications ( 59 ), sometimes even preceding their occurrence ( 60 ).…”

Section: The Potential Role Of the Gut Microbiota In The Complex Pathogenesis Of Sars-cov2 Infectionsmentioning

confidence: 99%

Perspective: Nutritional Strategies Targeting the Gut Microbiome to Mitigate COVID-19 Outcomes

Daoust

Pilon

Marette

2021

Advances in Nutrition

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More than a year has passed since the first reported case of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection in the city of Wuhan in China's Hubei Province. Until now, few antiviral medications (e.g., remdesivir) or drugs that target inflammatory complications associated with SARS-CoV2 infection have been considered safe by public health authorities. By the end of November 2020, this crisis had led to >1 million deaths and revealed the high susceptibility of people with pre-existing comorbidities (e.g., obesity, diabetes, coronary heart disease, hypertension) to suffer from a severe form of the disease. Elderly people have also been found to be highly susceptible to SARS-CoV2 infection and morbidity. Gastrointestinal manifestations and gut microbial alterations observed in SARS-CoV2–infected hospitalized patients have raised awareness of the potential role of intestinal mechanisms in increasing the severity of the disease. It is therefore critically important to find alternative or complementary approaches, not only to prevent or treat the disease, but also to reduce its growing societal and economic burden. In this review, we explore potential nutritional strategies that implicate the use of polyphenols, probiotics, vitamin D, and ω-3 fatty acids with a focus on the gut microbiome, and that could lead to concrete recommendations that are easily applicable to both vulnerable people with pre-existing metabolic comorbidities and the elderly, but also to the general population.

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Gastrointestinal manifestation as clinical predictor of severe COVID‐19: A retrospective experience and literature review of COVID‐19 in Association of Southeast Asian Nations (ASEAN)

Cited by 9 publications

References 23 publications

Severity of COVID-19 in Patients with Diarrhoea: A Systematic Review and Meta-Analysis

Severity of COVID-19 in Patients with Diarrhoea: A Systematic Review and Meta-Analysis

A machine learning approach for identification of gastrointestinal predictors for the risk of COVID-19 related hospitalization

Perspective: Nutritional Strategies Targeting the Gut Microbiome to Mitigate COVID-19 Outcomes

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