Gastrointestinal Lymphoma in 20 Dogs

Couto, C. Guillermo; Rutgers, H. C.; Sherding, Robert G.; Rojko, Jennifer L.

doi:10.1111/j.1939-1676.1989.tb03082.x

Cited by 118 publications

(130 citation statements)

References 6 publications

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“…1,61 In dogs, distinguishing between gastrointestinal lymphosarcoma and LPE on histologic examination is difficult, because many dogs with gastrointestinal lymphosarcoma have extensive intestinal infiltrates of lymphocytes and plasma cells. 61,62 In dogs, LPE may be a prelymphomatous intestinal disease, 61,62 and this might also be the case in horses. 37 …”

Section: Lymphocytic-plasmacytic Enterocolitis (Lpe)mentioning

confidence: 99%

Chronic Idiopathic Inflammatory Bowel Diseases of the Horse

Schumacher

Edwards

Cohen

2000

Veterinary Internal Medicne

180

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A review of reported cases of inflammatory bowel diseases (IBDs) of horses for which no etiology was identified included cases of granulomatous enteritis (GE), multisystemic eosinophilic epitheliotropic disease (MEED), lymphocytic-plasmacytic enterocolitis (LPE), and idiopathic eosinophilic enterocolitis (EC). The terms EC and MEED were both used to describe a disease in horses characterized by infiltration of intestine and extraintestinal tissues with eosinophils. We use EC to describe IBD characterized by only intestinal infiltration by eosinophils. Horses with GE, MEED, or LPE are usually examined because of weight loss and depression, but horses with EC are usually examined because of signs of abdominal pain. Typically, horses with IBD have low concentrations of serumal proteins, especially albumin, and fail to adequately absorb glucose or xylose. Antemortem diagnosis of IBD can only be made by histologic examination of affected intestine. In some cases, antemortem diagnosis is made from histologic examination of rectal mucosa obtained by biopsy. Suspected causes of IBD in the horse include abnormal immune response to bacterial, viral, parasitic, or dietary antigens. Most horses with IBD do not survive, but horses with EC are more likely than those with LPE, MEED, or GE to respond to treatment. Successful treatments of horses with IBD include resection of grossly affected intestine and administration of corticosteroids.Key words: Eosinophilic enterocolitis; Granulomatous enteritis; Lymphocytic-plasmacytic enterocolitis; Multisystemic eosinophilic epitheliotropic disease.C hronic inflammatory bowel diseases (IBDs) are associated with dysfunction of the gastrointestinal tract due to infiltration of the mucosa and submucosa with populations of eosinophils, plasma cells, lymphocytes, basophils, or macrophages. 1,2 Clinical signs of IBD in the horse include weight loss, dependent edema, and lethargy and are usually associated with protein-losing enteropathy and malabsorption of nutrients, including glucose. Affected horses may have diarrhea or signs of abdominal pain. Signalment, clinical signs, clinicopathologic findings, and postmortem lesions may be highly characteristic of some types of IBD in the horse, but, in general, clinical and gross pathologic features of these diseases are similar, and a final morphologic diagnosis is based on histologic examination. When an etiologic diagnosis of IBD has been reported, mycobacterial 3-12 or parasitic infections, 13,14 or toxins 15 have been identified. The purpose of this report is to describe distinguishing features and discuss possible etiologies of the idiopathic IBDs and to discuss treatment of affected horses. Granulomatous Enteritis (GE)This idiopathic condition was 1st reported in 1974 by Cimprich, 7 who noted the histologic similarity between this disease and Crohn's disease in humans. In our review of the reports of idiopathic GE, we found detailed descriptions of 47 affected horses. 6,7,9,[16][17][18][19][20][21][22][23][24][25] Of these, 32 were Standardbr...

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Section: Lymphocytic-plasmacytic Enterocolitis (Lpe)mentioning

confidence: 99%

Chronic Idiopathic Inflammatory Bowel Diseases of the Horse

Schumacher

Edwards

Cohen

2000

Veterinary Internal Medicne

180

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“…The alimentary form is common in cats [1,5,9,10], but uncommon in dogs, accounting for only 5 to 7% of all lymphomas [2,8]. It is generally believed that full thickness biopsy of the intestine is necessary to diagnose alimentary lymphoma as the lesions are usually deep-seated and invade the serosa.…”

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confidence: 99%

Endoscopic Findings on Alimentary Lymphoma in 7 Dogs

Miura

Maruyama

Sakai

et al. 2004

The Journal of Veterinary Medical Science

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ABSTRACT. Alimentary lymphoma was evaluated endoscopically in 7 dogs and a histopathological examination was made to detect the origin of neoplastic lymphocytes in 5 dogs. A solitary mass in the rectum (1 case), irregular cobblestone appearance in the duodenum (4 cases) and a moderate irregular appearance resembling lymphocytic-plasmacytic enteritis (2 cases) were endoscopically detected. Endoscopic ultrasonography demonstrated increased thickness of the duodenal wall in 2 cases examined. Neoplastic lymphocytes of alimentary lymphoma proved to originate in T cells in all 5 cases examined by immunohistochemical analysis. KEY WORDS: alimentary lymphoma, canine, endoscopy.

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“…The blood results in patients with alimentary lymphoma are non-specific, but often include neutrophilia, anaemia and hypoalbuminaemia (Couto et al 1989;Miura et al 2004;Frank et al 2007). Mild hypoalbuminaemia that normalised within 14 days following therapy was identified in the reported dog.…”

Section: Discussionmentioning

confidence: 99%

Gastrointestinal B-lymphoblastic lymphoma in a dog: a case report

Borska¹,

Husník²,

Fictum³

et al. 2018

Vet. Med. - Czech

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ABSTRACT:A four-year-old Bullmastiff weighing 44 kg was presented with a 14-day history of weight loss, vomiting and diarrhoea. Abdominal ultrasonography showed the presence of abdominal lymphadenopathy and thickening of the wall of the descending colon. Esophagogastroduodenoscopy and colonoscopy with biopsy were performed. Histological examination revealed a high-grade lymphoblastic lymphoma, flow cytometric analysis detected malignant cells of the immature B phenotype. PCR for antigen receptor rearrangement confirmed IgH monoclonality pointing together with immunophenotyping to B-cell lymphoma. The dog was treated using a multi-agent chemotherapy protocol. The overall survival time was 487 days. This was an unusual case of primary gastrointestinal B-lymphoblastic lymphoma in a dog with survival equivalent to that of the multicentric form.Keywords: canine; alimentary; lymphoid neoplasia; immunophenotyping; PARR; chemotherapy List of abbreviations:B-LBL = B-lymphoblastic lymphoma, FC = flow cytometry, FNAB = fine-needle aspiration biopsy, GI = gastrointestinal, LPE = lymphocytic-plasmacytic enteritis, PARR = polymerase chain reaction for antigen receptor rearrangement

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Gastrointestinal Lymphoma in 20 Dogs

Cited by 118 publications

References 6 publications

Chronic Idiopathic Inflammatory Bowel Diseases of the Horse

Chronic Idiopathic Inflammatory Bowel Diseases of the Horse

Endoscopic Findings on Alimentary Lymphoma in 7 Dogs

Gastrointestinal B-lymphoblastic lymphoma in a dog: a case report

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