Gastrointestinal lymphatic absorption of peptides and proteins

Rubas, Werner; Grass, George M.

doi:10.1016/0169-409x(91)90047-g

Cited by 30 publications

(6 citation statements)

References 161 publications

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“…The molecular weight also affects the routes by which bioactive peptides transfer into target sites [ 64 ]. Small molecular weight peptides could easily get through the gastrointestinal barrier and enter peripheral blood to promote its bioavailability at tissue level [ 65 ].…”

Section: Characteristics Of Antioxidant Peptidesmentioning

confidence: 99%

A Review of Antioxidant Peptides Derived from Meat Muscle and By-Products

et al. 2016

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Antioxidant peptides are gradually being accepted as food ingredients, supplemented in functional food and nutraceuticals, to positively regulate oxidative stress in the human body against lipid and protein oxidation. Meat muscle and meat by-products are rich sources of proteins and can be regarded as good materials for the production of bioactive peptides by use of enzymatic hydrolysis or direct solvent extraction. In recent years, there has been a growing number of studies conducted to characterize antioxidant peptides or hydrolysates derived from meat muscle and by-products as well as processed meat products, including dry-cured hams. Antioxidant peptides obtained from animal sources could exert not only nutritional value but also bioavailability to benefit human health. This paper reviews the antioxidant peptides or protein hydrolysates identified in muscle protein and by-products. We focus on the procedure for the generation of peptides with antioxidant capacity including the acquisition of crude peptides, the assessment of antioxidant activity, and the purification and identification of the active fraction. It remains critical to perform validation experiments with a cell model, animal model or clinical trial to eliminate safety concerns before final application in the food system. In addition, some of the common characteristics on structure-activity relationship are also reviewed based on the identified antioxidant peptides.

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Section: Characteristics Of Antioxidant Peptidesmentioning

confidence: 99%

A Review of Antioxidant Peptides Derived from Meat Muscle and By-Products

et al. 2016

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“…Tight junctions are opened and after sampling new tight junctional complexes between adjacent ECs are formed. Luminal sampling is upregulated in inflammatory conditions [ 43 , 44 ]. However, information is lacking whether protein transport occurs via these cells.…”

Section: Main Textmentioning

confidence: 99%

Application of the adverse outcome pathway (AOP) concept to structure the available in vivo and in vitro mechanistic data for allergic sensitization to food proteins

Bilsen¹,

Szłapka

Ojalvo

et al. 2017

Clin Transl Allergy

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BackgroundThe introduction of whole new foods in a population may lead to sensitization and food allergy. This constitutes a potential public health problem and a challenge to risk assessors and managers as the existing understanding of the pathophysiological processes and the currently available biological tools for prediction of the risk for food allergy development and the severity of the reaction are not sufficient. There is a substantial body of in vivo and in vitro data describing molecular and cellular events potentially involved in food sensitization. However, these events have not been organized in a sequence of related events that is plausible to result in sensitization, and useful to challenge current hypotheses. The aim of this manuscript was to collect and structure the current mechanistic understanding of sensitization induction to food proteins by applying the concept of adverse outcome pathway (AOP).Main bodyThe proposed AOP for food sensitization is based on information on molecular and cellular mechanisms and pathways evidenced to be involved in sensitization by food and food proteins and uses the AOPs for chemical skin sensitization and respiratory sensitization induction as templates. Available mechanistic data on protein respiratory sensitization were included to fill out gaps in the understanding of how proteins may affect cells, cell–cell interactions and tissue homeostasis. Analysis revealed several key events (KE) and biomarkers that may have potential use in testing and assessment of proteins for their sensitizing potential.ConclusionThe application of the AOP concept to structure mechanistic in vivo and in vitro knowledge has made it possible to identify a number of methods, each addressing a specific KE, that provide information about the food allergenic potential of new proteins. When applied in the context of an integrated strategy these methods may reduce, if not replace, current animal testing approaches. The proposed AOP will be shared at the www.aopwiki.org platform to expand the mechanistic data, improve the confidence in each of the proposed KE and key event relations (KERs), and allow for the identification of new, or refinement of established KE and KERs.

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“…Besides DCs, macro‐phages have been shown capable of transporting antigens across the intestinal tract using pseudopodia . After antigen uptake, the antigen‐containing macro‐phages enter the systemic circulation, leading to systemic reactions towards this antigen.…”

Section: Transport Of Allergens Across the Intestinal Tractmentioning

confidence: 99%

Protein transport across the small intestine in food allergy

Reitsma

Westerhout²,

Wichers

et al. 2013

Molecular Nutrition Food Res

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In view of the imminent deficiency of protein sources for human consumption in the near future, new protein sources need to be identified. However, safety issues such as the risk of allergenicity are often a bottleneck, due to the absence of predictive, validated and accepted methods for risk assessment. The current strategy to assess the allergenic potential of proteins focuses mainly on homology, stability and cross-reactivity, although other factors such as intestinal transport might be of added value too. In this review, we present an overview of the knowledge of protein transport across the intestinal wall and the methods currently being used to measure this. A literature study reveals that protein transport in sensitised persons occurs para-cellularly with the involvement of mast cells, and trans-cellularly via enterocytes, while in non-sensitised persons micro-fold cells and enterocytes are considered most important. However, there is a lack of comparable systematic studies on transport of allergenic proteins. Knowledge of the multiple protein transport pathways and which model system can be useful to study these processes may be of added value in the risk assessment of food allergenicity.

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Gastrointestinal lymphatic absorption of peptides and proteins

Cited by 30 publications

References 161 publications

A Review of Antioxidant Peptides Derived from Meat Muscle and By-Products

A Review of Antioxidant Peptides Derived from Meat Muscle and By-Products

Application of the adverse outcome pathway (AOP) concept to structure the available in vivo and in vitro mechanistic data for allergic sensitization to food proteins

Protein transport across the small intestine in food allergy

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