Gastrointestinal issues with behavior problems and sleep issues in children and adolescents with Autism pectrum disorder (ASD): A preliminary estimate

Kumar, Shankar; Venkatakrishna, Sneha; Ruth, Sharon

doi:10.1177/0973134220210307

Cited by 2 publications

(3 citation statements)

References 15 publications

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“…Children with ASD are more likely to experience constipation than TD children ( Supplementary Figure S2 , see the Supplementary Material ). Twelve articles ( 19 , 21 , 22 , 24 , 25 , 32 , 34 – 37 , 39 , 41 ) recorded cases of children with ASD complaining of simple abdominal pain. Seven studies ( 18 , 18 , 20 , 23 , 29 , 30 , 38 ) reported cases of defecation-related abdominal pain, and two ( 26 , 28 ) found no abdominal pain.…”

Section: Resultsmentioning

confidence: 99%

“…All 25 articles provided information on constipation in children with ASD, with an prevalence of 37% (95% CI: 0.30, 0.43), I 2 = 96.00%, p = 0.00 ( Supplementary Figure S7 , see the Supplementary Material ). A total of 22 articles ( 18 – 27 , 29 – 32 , 34 – 37 , 39 – 41 ) documented diarrhea in children with ASD, with a combined prevalence of 19% (95% CI: 0.14, 0.24), I 2 = 96.86%, p = 0.00 ( Supplementary Figure S8 , see the Supplementary Material ). Data on abdominal pain in children with ASD were reported in 21 articles ( 18 – 26 , 28 – 30 , 32 , 34 – 37 , 39 , 41 ), with an prevalence of 21% (95% CI: 0.14, 0.28), I 2 = 96.55%, p = 0.00 ( Supplementary Figure S9 , see the Supplementary Material ).…”

Section: Resultsmentioning

confidence: 99%

“…A total of 22 articles ( 18 – 27 , 29 – 32 , 34 – 37 , 39 – 41 ) documented diarrhea in children with ASD, with a combined prevalence of 19% (95% CI: 0.14, 0.24), I 2 = 96.86%, p = 0.00 ( Supplementary Figure S8 , see the Supplementary Material ). Data on abdominal pain in children with ASD were reported in 21 articles ( 18 – 26 , 28 – 30 , 32 , 34 – 37 , 39 , 41 ), with an prevalence of 21% (95% CI: 0.14, 0.28), I 2 = 96.55%, p = 0.00 ( Supplementary Figure S9 , see the Supplementary Material ). Data on vomiting were collected from 17 articles ( 18 – 19 , 21 , 33 – 25 , 28 , 29 , 33 – 35 , 37 – 41 ), with an prevalence of 8% (95% CI: 0.05, 0.12), I 2 = 94.11%, p = 0.00 ( Supplementary Figure S10 , see the Supplementary Material ).…”

Section: Resultsmentioning

confidence: 99%

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Questionnaire-based analysis of autism spectrum disorders and gastrointestinal symptoms in children and adolescents: a systematic review and meta-analysis

Gan

Zhang

et al. 2023

Front. Pediatr.

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BackgroundGastrointestinal (GI) symptoms are frequently experienced by children with autism spectrum disorder (ASD), and these symptoms cause difficulties for these children and their families. However, studies of GI symptom prevalence differ significantly. This meta-analysis aimed to analyze the prevalence of GI symptoms in children with ASD.Methods and findingsPubMed, Scopus, Web of Science, EMBASE were electronically searched to collect all literature on gastrointestinal symptoms of children with ASD collected through questionnaires or scales from January 2012 to May 2021. Four researchers independently scanned the literature and extracted information on general characteristics. First author name, year of publication, geographical location, type of study, sample sizes of ASD and control (if any) children, sex and average age, number of GI cases, number of GI symptoms, GI assessment tools (gastrointestinal symptoms scale), autism diagnosis methods, and other necessary data were collected and analyzed using Stata V16. The questionnaires included the Rome, 6-GSI, GIQ, GSRS, GSIQ, ADI-R, PedsQL-GI, parent-report, GI-related, and self-administered questionnaires. Compared with typically developing (TD) children, the odds ratio for In children with ASD with at least one GI symptom was 3.64, and the total prevalence was 55%. The cumulative prevalence rates of various symptoms were summarized, showing that 37% of children with ASD had constipation, 21% had abdominal pain, 19% had diarrhea, 8% had vomiting, and 23% had abdominal distension.ConclusionsThe results of this meta-analysis on GI symptoms in ASD show that patients with ASD are more likely to develop symptoms than TD children. The prevalence of GI symptoms in In children with ASD was 55%.Systematic Review Registrationwww.crd.york.ac.uk/PROSPERO, identifier, #CRD42017080579.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Questionnaire-based analysis of autism spectrum disorders and gastrointestinal symptoms in children and adolescents: a systematic review and meta-analysis

Gan

Zhang

et al. 2023

Front. Pediatr.

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Symptoms of constipation in autistic adults: A systematic literature review on diagnostic methods and presence of actual symptoms

Smith,

Desprez

2024

Autism

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Autism significantly impacts how individuals interact, communicate and perceive the world. Gastrointestinal disturbances, particularly constipation, are prevalent among autistic people, affecting their overall well-being. However, to the best of our knowledge, no specific guidelines are currently available regarding the diagnosis of constipation among this population. This systematic review investigates various diagnostic methods employed in studies addressing constipation among autistic adults. It aims to identify discrepancies between the symptoms reported based on diagnostic methods and the actual symptoms experienced by this population. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, nine studies conducted between 2012 and 2022 were included, revealing a predominance of non-prospective designs and an emphasis on children and adolescents. Diagnostic tools varied, including standardized criteria, questionnaires and observation. The prevalence of symptoms not outlined in the official criteria, such as sleep disorders and challenging behaviours, emerged as crucial aspects requiring comprehensive assessment in autistic people experiencing constipation. The study highlights the need for age-specific research in order to develop tailored assessment tools to improve diagnostic accuracy and enhance the overall management of constipation in autistic adults. Recognizing the diverse manifestations of constipation in this population is crucial for developing nuanced interventions and advancing healthcare strategies. Lay abstract Autistic people often experience gastrointestinal issues, with constipation being one of the most common concerns. However, there are currently no specific guidelines for diagnosing constipation in autistic adults. This makes it harder for healthcare providers to identify and treat the condition effectively. In this review, we analysed nine studies from 2012 to 2022 to understand the various methods used to diagnose constipation in autistic adults and their symptoms. We found that most studies used different approaches, such as questionnaires, standardized criteria, or observation. In addition, many studies focused on children and adolescents, leaving a gap in understanding symptoms in autistic adults. The studies highlighted symptoms that were not covered by official diagnostic criteria, such as sleep disturbances and challenging behaviours. This indicates a need for healthcare providers to consider a broader range of signs when diagnosing constipation in autistic people. Our review suggests that more research focusing on adults is needed to create tailored tools for diagnosing constipation in autistic adults. This will help improve accuracy and ensure better treatment outcomes. Understanding the unique ways constipation can present in autistic people is crucial for developing effective care strategies. For healthcare providers, this review emphasizes the importance of recognizing a wide range of symptoms when assessing constipation in autistic people. For policymakers, it highlights the need for age-specific guidelines to ensure that autistic adults receive the care and support they need. Further research will help refine these diagnostic tools and ultimately lead to better healthcare practices for autistic people.

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Gastrointestinal issues with behavior problems and sleep issues in children and adolescents with Autism pectrum disorder (ASD): A preliminary estimate

Cited by 2 publications

References 15 publications

Questionnaire-based analysis of autism spectrum disorders and gastrointestinal symptoms in children and adolescents: a systematic review and meta-analysis

Questionnaire-based analysis of autism spectrum disorders and gastrointestinal symptoms in children and adolescents: a systematic review and meta-analysis

Symptoms of constipation in autistic adults: A systematic literature review on diagnostic methods and presence of actual symptoms

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