Gastrointestinal Hormones

Welcome, M. Osain

doi:10.1007/978-3-319-91056-7_8

Cited by 2 publications

(4 citation statements)

References 364 publications

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“…Several studies have found that hormones synthesized by intestinal cells and gut microbiomes can affect AD through neural and humoral pathways ( Welcome, 2018 ). Notably, the microbiome may also regulate hormone levels ( Yan et al, 2016 ; Engevik et al, 2020 ), suggesting that gut hormones may also be potential biomarkers of AD.…”

Section: Microbiome-based Ad Biomarkersmentioning

confidence: 99%

The potential of the gut microbiome for identifying Alzheimer’s disease diagnostic biomarkers and future therapies

Zhan¹,

Al‐Nusaif²,

Ding³

et al. 2023

Front. Neurosci.

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Being isolated from the peripheral system by the blood–brain barrier, the brain has long been considered a completely impervious tissue. However, recent findings show that the gut microbiome (GM) influences gastrointestinal and brain disorders such as Alzheimer’s disease (AD). Despite several hypotheses, such as neuroinflammation, tau hyperphosphorylation, amyloid plaques, neurofibrillary tangles, and oxidative stress, being proposed to explain the origin and progression of AD, the pathogenesis remains incompletely understood. Epigenetic, molecular, and pathological studies suggest that GM influences AD development and have endeavored to find predictive, sensitive, non-invasive, and accurate biomarkers for early disease diagnosis and monitoring of progression. Given the growing interest in the involvement of GM in AD, current research endeavors to identify prospective gut biomarkers for both preclinical and clinical diagnoses, as well as targeted therapy techniques. Here, we discuss the most recent findings on gut changes in AD, microbiome-based biomarkers, prospective clinical diagnostic uses, and targeted therapy approaches. Furthermore, we addressed herbal components, which could provide a new venue for AD diagnostic and therapy research.

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Section: Microbiome-based Ad Biomarkersmentioning

confidence: 99%

The potential of the gut microbiome for identifying Alzheimer’s disease diagnostic biomarkers and future therapies

Zhan¹,

Al‐Nusaif²,

Ding³

et al. 2023

Front. Neurosci.

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“…In the absorbent intestine, the transport of solutes from the intestinal lumen into the epithelial cell generates a temporary local osmotic gradient and therefore drives the water movement crossing the cell membrane. 93 The introduction of water raises the hydrostatic pressure within the cells, which results in a bulk flow of water and solutes into the capillaries. 90 The inversed flow of fluids is generated from the intercellular space to the lumen in the secreting portion of the intestine.…”

Section: Water Transport In the Gastrointestinalmentioning

confidence: 99%

“…Apart from the passive diffusions, the small intestine moves constantly to stir and propel the food mixture toward the end of the tract for effective absorption. 93 Segmentation contraction occurs regularly in the small intestine through alternating activation of circular muscles to provide a radial stirring effect and therefore to increase the effective contacting area between the mixture in the lumen and the absorbing epithelial cells. 94 The axial movement of luminal content is driven by the intestine squirming through periodic contraction and relaxation of circular and longitudinal muscle layers.…”

Section: Water Transport In the Gastrointestinalmentioning

confidence: 99%

“…On the other side, ion concentrations in the lumen are in balance with those in plasma because of the relative permeability of the absorptive epithelial cells. In the absorbent intestine, the transport of solutes from the intestinal lumen into the epithelial cell generates a temporary local osmotic gradient and therefore drives the water movement crossing the cell membrane . The introduction of water raises the hydrostatic pressure within the cells, which results in a bulk flow of water and solutes into the capillaries .…”

Section: Physiology Of Vascular Systems In Plants and Humansmentioning

confidence: 99%

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Characterizing Flow and Transport in Biological Vascular Systems: A Review from Physiological and Chemical Engineering Perspectives

Chen,

Zhu,

Luo

2023

Ind. Eng. Chem. Res.

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The investigation of biological fluidic mechanisms is a persistent topic of interest and offers valuable inspiration to address the challenges confronting chemical engineering, particularly with respect to the obligations of sustainability. Accordingly, given the advancements of multidisciplinary integration and digital transformation, the methodologies in chemical engineering represent potent instruments for characterizing the flow and transport features of biological vascular systems. In this Review, a qualitative explication of common tubular structures and their corresponding biofluid patterns in both vascular plants and humans is provided, grounded in a physiological perspective. Theoretical and numerical models, such as computational fluid dynamics (CFD), in engineering are introduced as effective and efficient prediction and analysis tools for quantitatively characterizing biofluid transport mechanisms, including fluid−structure interactions. Furthermore, typical pathologies resulting from multiphase biofluid dysfunction in vascular organisms are analyzed with physiological and chemical engineering methodologies. The integrated perspective provides an opportunity to extend the fundamental understanding of biological processes and in turn promotes the nature-inspired transformative advancements in the field of chemical engineering.

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Gastrointestinal Hormones

Cited by 2 publications

References 364 publications

The potential of the gut microbiome for identifying Alzheimer’s disease diagnostic biomarkers and future therapies

The potential of the gut microbiome for identifying Alzheimer’s disease diagnostic biomarkers and future therapies

Characterizing Flow and Transport in Biological Vascular Systems: A Review from Physiological and Chemical Engineering Perspectives

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