Gastrointestinal histoplasmosis: a case series from a non-endemic region in North India

Mandavdhare, Harshal; Shah, Jimil; Prasad, K. N.; Agarwala, Roshan; Suri, Vikas; Kumari, Savita; Dutta, Usha; Sharma, Vishal

doi:10.5217/ir.2018.00111

Cited by 7 publications

(12 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Analysis of the 123 well-documented cases showed the clinical presentation of GIH was often non-specific and mimicked several other gastrointestinal conditions and pathologies, including abdominal tuberculosis (n = 3, 2.4%) [ 85 , 96 , 102 ], GIH and TB coinfection was reported in four [3.3%] cases [ 78 , 87 , 96 , 98 ], inflammatory bowel disease (n = 9, 7.3%) [ 21 , 33 , 40 , 52 , 69 , 75 , 89 , 105 , 107 ], intestinal obstruction (n = 15, 12.2%) [ 15 , 21 , 39 , 50 , 57 , 64 , 71 , 77 , 81 , 89 , 95 , 102 , 103 , 104 , 117 ], abdominal malignancy (n = 9, 7.3%) [ 14 , 16 , 31 , 80 , 83 , 101 , 102 , 108 , 112 ], GI bleeding (n = 29, 23.6%) [ 17 , 18 , 25 , 26 , 27 , 29 , 30 , 31 , 33 , 37 , 41 , 44 , 53 , 56 ,…”

Section: Resultsmentioning

confidence: 99%

“…The non-specific signs and symptoms of GIH, as highlighted in this review, include but are not limited to abdominal pain [ 12 , 18 , 19 , 20 , 20 , 21 , 22 , 25 , 27 , 31 , 33 , 35 , 36 , 37 , 38 , 40 , 41 , 43 , 45 , 47 , 50 , 51 , 54 ], diarrhoea [ 12 , 17 , 19 , 21 , 22 , 36 , 37 , 38 , 39 , 40 , 43 , 53 , 68 , 74 , 75 , 103 , 104 , 105 , 106 ], fever [ 12 , 13 , 17 , 19 , 26 , 27 , 28 , 30 , 31 , 33 , 35 ], weight loss [ 13 , 31 , 77 , 79 , 84 , …”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Gastrointestinal Histoplasmosis: A Descriptive Review, 2001–2021

Ekeng

Itam-Eyo

Osaigbovo

et al. 2023

Life

View full text Add to dashboard Cite

Gastrointestinal histoplasmosis (GIH) is infrequently described in people without underlying HIV infection. We aimed to compare the clinical presentation of GIH in people with and without HIV infection. We conducted a literature search of published cases of GIH from 2001–2021 and found 212 cases. Of these, 142 (67.0%) were male, and 124 (58.5%) had HIV infection. Most cases were from North America (n = 88, 41.5%) and South America (n = 79, 37.3%). Of the 212 cases, 123 (58.0%) were included in both clinical and pathological analyses. The remainder were excluded as details about clinical and pathological findings were not available. Of the 123 cases, 41 had HIV infection while 82 were without HIV infection. The diagnosis was predominantly by histopathology (n = 109, 88.6%). A significant proportion of people with HIV infection had abdominal pain as the most predominant symptom of GIH compared to those without HIV infection (65.9% versus 41.9%, p < 0.05). The colon was the most affected site with a slightly higher proportion in those with HIV infection compared with cases without HIV infection (46.3% versus 42.7%). The commonest pathologic findings were caecal and ileal ulcers. Caecal ulcers were significantly more frequent in cases with HIV infection compared to those without HIV (32.1% versus 7.1%, p < 0.05). Despite being more common in people with HIV infection, GIH also affects people without HIV infection with similar clinical presentations.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Gastrointestinal Histoplasmosis: A Descriptive Review, 2001–2021

Ekeng

Itam-Eyo

Osaigbovo

et al. 2023

Life

View full text Add to dashboard Cite

show abstract

“…Diabetes 41 [30,35,47,48,53,59] Chronic granulomatous disease 2 [52,55] Corticosteroid therapy 3 [9,22,38] Other immunosuppressive therapies 2 [22,38] Idiopathic CD4 lymphocytopenia 2 [27,35] Kidney transplant 1 [29] TB with severe malnutrition 1 [35] Lymphoma 1 [35] Chronic liver disease 1 [59] Chronic kidney disease 1 [59] Total 55 13.75% was observed among 2,729 people from Bangladesh (formerly called East Pakistan) [92]. Meanwhile, all of the 575 people (healthy participants, schoolchildren and TB and leprosy patients) showed a zero rate of histoplasmin sensitivity in Pakistan [93].…”

Section: No Of Cases Referencementioning

confidence: 99%

The Review of Histoplasmosis Endemicity and Current Status in Asia

Rozaliyani¹,

Setianingrum²

2020

Histoplasma and Histoplasmosis

View full text Add to dashboard Cite

Histoplasmosis is a common disease among immunocompromised patients and a notable endemic disease among immunocompetent patients. Disseminated histoplasmosis in acquired immunodeficiency syndrome (AIDS) patients is mostly lethal. We conducted a literature review of histoplasmosis and histoplasmin skin test in Asia. There were around 1692 cases of histoplasmosis reported from Asian countries. India (623 cases), China (611 cases) and Thailand (234 cases) are detected as endemic areas of histoplasmosis although the complete mapping of this disease is still missing in some Asian countries. However, definite diagnosis is difficult since the symptoms frequently mimicking tuberculosis (TB), tissue samples are rarely obtained, and lacked of serology tests in Asian countries.

show abstract

“…In 26% of cases, histopathology showed nonspecific changes, and the patients were asymptomatic on follow up without any treatment . The various causes of ICT are listed in Table …”

Section: Causes Of Ictmentioning

confidence: 99%

“…Discrete granulomas and giant cells can also be seen in some cases. Periodic acid‐Schiff (PAS) staining demonstrates the presence of intracellular uniform, ovoid, uninucleate yeast with eccentrically placed nuclei and peripheral halo, suggestive of histoplasma . Bacterial enterocolitis usually shows nonspecific neutophilic inflammation, cryptitis, crypt abscesses, and absence of basal plasmacytosis.…”

Section: Histologymentioning

confidence: 99%

Ileocecal thickening: Clinical approach to a common problem

et al. 2019

Self Cite

View full text Add to dashboard Cite

Ileocecal thickening (ICT) is a common finding on radiological imaging. It can be caused by a variety of inflammatory, infectious, or neoplastic conditions, and evaluating a patient of ICT can be a challenging task. Intestinal tuberculosis (ITB), Crohn's disease (CD), and adenocarcinoma are the most common causes. Enteric bacterial infections, cytomegalovirus, histoplasmosis, amebiasis, systemic vasculitis, lymphoma, etc. should be suspected in appropriate clinical settings. However, it could often be a spurious or nonspecific finding. A thickness of more than 3 mm in a normally distended small bowel is usually considered abnormal. Detailed evaluation of imaging of the site and extent of thickening; the degree and pattern of thickening; and the associated findings, such as degree of fat stranding, fibrofatty proliferation, adjacent lymph nodes, and solid organ involvement, should be performed. Ileocolonoscopy is an important tool for diagnosing and obtaining samples for tissue diagnosis. Histopathology is usually the gold standard for diagnosis, although-not uncommonly-findings could be nonspecific, and reaching a definitive diagnosis is difficult. As such, a systematic approach with the integration of clinical, biochemical, radiological, endoscopic, histological, and other laboratory tests is the key to reaching a diagnosis. In this article, we review the causes of ICT and present a clinical approach for the management of ICT. Causes of ICTThe ileocecal area could be involved by a variety of conditions, including benign or malignant tumors, infections, inflammatory conditions, ischemia, etc. However, ICT can also be a spurious finding, without any underlying cause. In various studies on bowel wall thickening, a normal ileocolonoscopy has been found

show abstract

Gastrointestinal histoplasmosis: a case series from a non-endemic region in North India

Cited by 7 publications

References 7 publications

Gastrointestinal Histoplasmosis: A Descriptive Review, 2001–2021

Gastrointestinal Histoplasmosis: A Descriptive Review, 2001–2021

The Review of Histoplasmosis Endemicity and Current Status in Asia

Ileocecal thickening: Clinical approach to a common problem

Contact Info

Product

Resources

About