Gastrointestinal hemorrhage due to metastatic choriocarcinoma with gastric and colonic involvement

Abstract

Metastatic choriocarcinoma is a rare nonseminomatous germcell tumor with a characteristic hemorrhagic tendency due to its trophoblastic origin. Gastrointestinal tube involvement is present in less than 5% of cases, and location or therapy of these lesions can be achieved by endoscopy, angiography or surgery. Despite its being a highly curable malignant disease, the ocurrence of gastrointestinal bleeding worsens prognosis. We report a case of metastatic choriocarcinoma which manifested as melaena and was diagnosed by the presence of metastatic lesions in the stomach and right bowel on endoscopy.

Testicular Choriocarcinoma with Jejunal Metastasis Complicated by Intestinal Perforation and Acute Peritonitis

“…Most of these complications have been described in patients with gestational tro- phoblastic disease, but testicular choriocarcinoma in males behaves similarly [10,11]. In many cases bleeding is also the first manifestation of choriocarcinoma metastatic to the gastrointestinal tract [9,12]. Bleeding secondary to metastatic involvement of the small intestine has also been described in other testicular tumors, e.g.…”

Metastatic Testicular Choriocarcinoma: A Rare Cause of Upper GI Bleeding

“… 3 The stomach is the most common GI location; however, several case studies have reported lesions in the small intestine and colon. 10 It is important to distinguish a primary testicular choriocarcinoma metastasizing to the GI tract from a primary gastric choriocarcinoma. 2 Some authors recommend a testicular wedge biopsy, even in cases where a palpable testicular mass or radiologic evidence cannot be found, before labeling it as a primary gastric choriocarcinoma.…”

Hemoperitoneum secondary to bleeding of a hepatic metastasis of testicular carcinoma

“…It can disseminate as through lymphatic via hematic; it shows a good response to chemotherapy in spite of metastasis and possesses a 5-years survival rate ranging from 70 to 80%. However, the prognosis is worse if hemorrhagic complications are present [9]. Besides these features, it has a high proliferation rate, invasiveness, vascularization and bleeding tendency as consequence of tumoral necrosis and coagulation disorders.…”